Abstract: Polyionic derivatives of cyclodextrin polymers and cyclodextrins immobilized on a solid surface are disclosed. Compositions and methods for separating a molecular species, including but not limited to a biologically active protein, from a mixture, for the storage of protein factors and for the therapeutic biodelivery of protein factors which employ the polyionic derivatives of cyclodextrin polymers and cyclodextrins immobilized on a solid surface are also disclosed.
Type:
Grant
Filed:
October 9, 1992
Date of Patent:
November 16, 1993
Assignee:
The Trustees of the University of Pennsylvania/Childrens Hospital Corporation
Abstract: Polyionic derivatives of cyclodextrin polymers and cyclodextrins immobilized on a solid surface are disclosed. Compositions and methods for separating a molecular species, including but not limited to a biologically active protein, from a mixture, for the storage of protein factors and for the therapeutic biodelivery of protein factors which employ the polyionic derivatives of cyclodextrin polymers and cyclodextrins immobilized on a solid surface are also disclosed.
Type:
Grant
Filed:
February 15, 1990
Date of Patent:
February 2, 1993
Assignee:
The Trustees of the University of Pennsylvania/Childrens Hospital Corporation
Inventors:
Paul B. Weisz, Yuen W. Shing, Judah Folkman
Abstract: Pathological or otherwise undesirable cell or tissue growth in mammals, including humans, is inhibited by administering thereto a composition exemplified by (1) a water-soluble cyclodextrin sulfate salt, together with (2) a growth-inhibiting organic compound. The growth-inhibiting compound (2) may be a steroid having no inhibiting effect in the absence of (1), or an organic compound which may be an active growth inhibitor, the action of which is potentiated by (1). The invention provides a method for inhibiting angiogenesis and controlling the growth of tumors as well as treating other diseases and pathological conditions associated with undesired cell or tissue growth, including angiogenesis.
Type:
Grant
Filed:
November 9, 1989
Date of Patent:
May 28, 1991
Assignee:
The Trustees of the University of Pennsylvania/Childrens Hospital Corporation