Abstract: The present invention provides a reading test to measure vision loss. In one embodiment, the vision loss is due to disease progression. The tests are useful in evaluating the effects of intervention in vision deterioration. The tests are non-invasive, simple, quick, sensitive, reproducible, and easy to administer. The tests measure the subject's reading speed and accuracy under defined conditions of illumination and contrast. The results of these tests may be used to determine if treatment of a disease should be initiated, terminated, altered, or remain unchanged.

Abstract: The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell to express a CAR wherein the CAR comprises an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain.

Abstract: A method and apparatus for classifying possibly malignant lesions from sets of DCE-MRI images includes receiving a set of MRI slice images obtained at respectively different times, where each slice image includes voxels representative of at least one region of interest (ROI). The images are processed to determine the boundaries of the ROIs and the voxels within the identified boundaries in corresponding regions of the images from each time period are processed to extract kinetic texture features. The kinetic texture features are then used in a classification process which classifies the ROIs as malignant or benign. The malignant lesions are further classified to separate TN lesions from non-TN lesions.

Abstract: This inventive subject matter relates to novel metal complex protein kinases inhibitors, methods for making such compounds, and methods for using such compounds for treating diseases and disorders mediated by kinase activity.

Abstract: RNA interference using small interfering RNAs which are specific for the vascular endothelial growth factor (VEGF) gene and the VEGF receptor genes Flt-1 and Flk-1/KDR inhibit expression of these genes. Diseases which involve angiogenesis stimulated by overexpression of VEGF, such as diabetic retinopathy, age related macular degeneration and many types of cancer, can be treated by administering the small interfering RNAs.

Abstract: A technique for accurately measuring two different spin configurations of transverse magnetization from which the reversible dephasing rate constant R.sub.2 ' can be calculated. Such reversible dephasing may be caused by magnetic field inhomogeneity such as arising from intravascular changes in the oxidation state of hemoglobin, from brain iron, or from cancellous bone, which allows these characteristics to be measured. The different spin configurations can be measured in a single scan by deriving a small R.sub.2 ' through independent and separate measurements of the two magnetization configurations generated by two RF pulses. The two configurations can be recalled independently of each other since they are affected differently by respective gradients flanking the .beta.-pulse which permit one spin configuration to decay with T.sub.2 while the other decays with T.sub.2 * from the same RF pulse.

Abstract: The "next best view" (NBV) problem encountered while acquiring the surface geometry of an object using a range scanner is solved by determining the next position for the range scanner given its previous scans of the object. A new representation, positional space, is used as a unified data structure for representing what must be and what can be scanned. The image of the range scanner in positional space is computed off-line for particular positions of the range scanner in its work space and stored in a file. Then, when the next best view is to be determined during the analysis of the object, each scanner image is simply retrieved from the file instead of being recreated by translating the scanner image calculated for some other position on the work space of the range scanner. A linear objective function of the stored scanner images and images of a seen and an unseen surface of the object is then maximized over all scanner positions to determine the next best view.