Abstract: This invention relates to methods of treating and ameliorating congenital and neonatal hyperinsulinism and post-prandial hypoglycemia, comprising the step of administering an antagonist of the Glucagon-Like Peptide-1 (GLP-1) receptor, e.g. a GLP-1 fragment or analogue thereof.
Type:
Application
Filed:
February 14, 2023
Publication date:
March 14, 2024
Applicants:
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, The Children's Hospital of Philadelphia
Inventors:
Doris STOFFERS, Diva D. DE LEON, Charles STANLEY
Abstract: The present invention provides recombinant peptides comprising a B cell receptor (BCR) or a fragment thereof, nucleotide molecules encoding same, and vaccines and vectors comprising same; and methods of treating, inducing an immune response against, inducing a regression of, and suppressing a formation of a lymphoma, comprising administering same. The present invention also provides methods of inducing a humoral immune response in an animal against an antigen, comprising administering to the animal a fusion peptide comprising an LLO protein or fragment thereof fused to the antigen.
Type:
Grant
Filed:
July 11, 2014
Date of Patent:
January 1, 2019
Assignee:
The Trustees of the University of Philadelphia
Abstract: Monodisperse particles having: a single pure crystalline phase of a rare earth-containing lattice, a uniform three-dimensional size, and a uniform polyhedral morphology are disclosed. Due to their uniform size and shape, the monodisperse particles self assemble into superlattices. The particles may be luminescent particles such as down-converting phosphor particles and up-converting phosphors. The monodisperse particles of the invention have a rare earth-containing lattice which in one embodiment may be an yttrium-containing lattice or in another may be a lanthanide-containing lattice. The monodisperse particles may have different optical properties based on their composition, their size, and/or their morphology (or shape).
Type:
Grant
Filed:
October 8, 2015
Date of Patent:
September 12, 2017
Assignees:
INTELLIGENT MATERIAL SOLUTIONS, INC., THE TRUSTEES OF THE UNIVERSITY OF PHILADELPHIA
Inventors:
Joshua E. Collins, Howard Y. Bell, Xingchen Ye, Christopher Bruce Murray