Abstract: The present invention relates to methods for use in treating or preventing infections. More particularly, the invention relates to methods for screening for modulators that inhibit cyclin-dependent kinase and the use of these putative inhibitors to control proliferation of a DNA virus that is dependent upon events associated with cell proliferation for replication. The DNA virus includes any of the herpesvirus family, and most particularly human cytomegalovirus.
Type:
Application
Filed:
October 10, 2001
Publication date:
December 16, 2004
Applicants:
The Trustees of University of Pennsylvania and Board of Regents, The University of Texas System
Inventors:
Thomas Albrecht, Laurent Meijer, Priscilla Schaffer, Luis Schang