Abstract: Non-viral delivery systems comprising engineered hOTC DNA and RNA sequences are provided which when delivered to a subject in need thereof are useful for treating hyperammonemia, ornithine transcarbamylase transcarbamylase deficiency and symptoms associated therewith. Also provided are methods of using hOTC for treatment of liver fibrosis and/or cirrhosis in OTCD patients by administering hOTC.
Type:
Application
Filed:
March 9, 2015
Publication date:
January 26, 2017
Applicant:
The Trustess of the University of Pennsylvania
Abstract: A double-sided grating divider acts as a light switch where the upper and lower grating dividers are arranged to accommodate a relative lateral shift therebetween of about one-fourth of the period of the diffraction grating elements and where the critical refraction angles of the grating dividers are more than about 43.6°. Lateral shift may be achieved by various devices including MEMS and metal couplers having a known/calibrated thermal coefficient of expansion over a temperature range of interest.
Type:
Grant
Filed:
December 2, 2011
Date of Patent:
March 15, 2016
Assignees:
Toyota Motor Engineering & Manufacturing North America, Inc., The Trustess of the University of Pennsylvania
Abstract: The present invention discloses methods of use of facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers, including, but not limited to, pharmaceutical uses of the polymers and oligomers as antimicrobial agents and as antidotes for hemorrhagic complications associated with heparin therapy. The present invention also discloses novel facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers, compositions of the novel polymers and oligomers, including pharmaceutical compositions, and methods of designing and synthesizing the facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers.
Type:
Grant
Filed:
February 3, 2012
Date of Patent:
May 6, 2014
Assignee:
The Trustess of the University of Pennsylvania
Inventors:
William F. DeGrado, Dahui Liu, Gregory N. Tew, Michael L. Klein
Abstract: A recombinant vector comprises simian adenovirus SAdV-31 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus SAdV-31 gene(s) is also disclosed. Methods of using the vectors and cell lines are provided.
Type:
Grant
Filed:
November 24, 2008
Date of Patent:
July 31, 2012
Assignee:
The Trustess of the University of Pennsylvania
Inventors:
Soumitra Roy, James M. Wilson, Luc H. Vandenberghe
Abstract: A method for preparation of an anode for a solid oxide fuel cell in which a plurality of zircon fibers are mixed with a yttria-stabilized zirconia (YSZ) powder, forming a fiber/powder mixture. The fiber/powder mixture is formed into a porous YSZ layer and calcined. The calcined porous YSZ layer is then impregnated with a metal-containing salt solution. Preferred metals are Cu and Ni.
Type:
Application
Filed:
June 2, 2003
Publication date:
November 13, 2003
Applicant:
Trustess of The University of Pennsylvania.
Inventors:
Raymond J. Gorte, John M. Vohs, Radu Craciun
Abstract: A method of selectively adsorbing propylene in mixtures of propylene/propane and propylene/olefins through the use of zeolites having structures with a maximum of 8-member rings of tetraheda controlling the diffusion rate. Suitable zeolite adsorbents are those having the CHA and ITE structure types. Other 8-member ring zeolites, including aluminosilicates, with a Si:Al molar ratio of at least about 200 and having substantially no free acid are also suitable adsorbents.
Type:
Grant
Filed:
April 27, 2001
Date of Patent:
December 3, 2002
Assignee:
The Trustess of the University of Pennsylvania
Abstract: Methods for improving the corrosion inhibition of a metal or metal alloy substrate surface are provided wherein the substrate surface is coated with a polyaniline film. The polyaniline film coating is applied by contacting the substrate surface with a solution of polyaniline. The polyaniline is dissolved in an appropriate organic solvent and the solvent is allowed to evaporate from the substrate surface yielding the polyaniline film coating.
Type:
Grant
Filed:
February 14, 1995
Date of Patent:
July 8, 1997
Assignee:
The Trustess of the University of Pennsylvania
Abstract: Methods for preparing highly conductive, oriented polymers are disclosed. In the preferred embodiment, solution of conductive polymer is cast onto the surface of a stretchable support material, and oriented polymer is produced by removing solvent from the solution and stretching the support material. The invention is particularly useful for preparing oriented films of polyaniline which films have been shown to exhibit conductivities in the range of 300-2500 S/cm.
Type:
Grant
Filed:
February 3, 1989
Date of Patent:
June 19, 1990
Assignee:
Trustess of the University of Pennsylvania
Inventors:
Nicolas Theophilou, Sanjeev Manohar, Elliot Scherr