Patents Assigned to The U.S.A., as represented by the Secretary, Depart. of Health and Human Service
  • HMGN POLYPEPTIDES AS IMMUNE ENHANCERS AND HMGN ANTAGONISTS AS IMMUNE SUPPRESSANTS
    Publication number: 20120269839
    Abstract: A method of enhancing an antigen-specific immune response in a host comprising administering to the host an HMGN polypeptide comprising at least one of HMGN1, HMGN3a, HMGN3b, HMGN4, Nsbp1, or a functional fragment thereof, in an amount effective to enhance an antigen-specific immune response; as well as a pharmaceutical composition comprising an HMGN polypeptide comprising at least one of HMGN1, HMGN3a, HMGN3b, HMGN4, Nsbp1, or a functional fragment thereof, and an antigen, or nucleic acids encoding such molecules; and related methods and compositions.
    Type: Application
    Filed: June 26, 2012
    Publication date: October 25, 2012
    Applicant: The U.S.A. as represented by the Secretary,Depart. of Health and Human Services
    Inventors: De Yang, Joost J. Oppenheim, Michael Bustin
  • NOVEL MHC CLASS II RESTRICTED T CELL EPITOPES FROM THE CANCER ANITGEN, NY ESO-1
    Publication number: 20100021468
    Abstract: The present invention discloses the identification and isolation of novel MHC class II epitopes derived from the cancer antigen, NY ESO-1. The novel MHC class II epitopes from NY-EsO-1 are recognized by CD4+ T lymphocytes in an HLA class II restricted manner, in particular HLA-DR or HLA-DP restricted. The products of the gene are promising candidates for immunotherapeutic strategies for the prevention, treatment and diagnosis of patients with cancer.
    Type: Application
    Filed: September 28, 2009
    Publication date: January 28, 2010
    Applicant: The U.S.A., as represented by the Secretary, Depart. of Health and Human Service
    Inventors: Rong-Fu Wang, Steven A. Rosenberg, Gang Zeng