Patents Assigned to The U.S Govt. as represented by the Dept. of Veterans Affairs
  • Standardized measurement of physiological pressures using an air-charged catheter apparatus
    Patent number: 10537274
    Abstract: Systems and methods are provided for providing a standardized pressure value representing a transient pressure event within a region of interest within a living body. An air-charged catheter is configured to record pressure data representing the region of interest. A measurement assembly includes a parameter calculation component configured to calculate at least a peak pressure representing the transient pressure event and a time to peak pressure, representing the time necessary to reach the peak pressure, from the recorded pressure data. A standardization component is configured to calculate the standardized pressure value as a function of the peak pressure and the time to peak pressure. A user interface is configured to display at least the standardized pressure value at an associated display.
    Type: Grant
    Filed: September 21, 2012
    Date of Patent: January 21, 2020
    Assignees: THE U.S. GOVT AS REPRESENTED BY THE DEPT. OF VETERANS AFFAIRS, THE CLEVELAND CLININC FOUNDATION
    Inventors: Margot Damaser, Hassan K. Awada, Paul C. Fletter, Mitchell Cooper, Paul Zaszczurynski
  • USE OF PKC-IOTA INHIBITORS FOR THE TREATMENT OF GLIOMA
    Publication number: 20130058932
    Abstract: The present invention pertains to use of PKC-iota inhibitors for treatment of glioma. In a specific embodiment, the treatment method comprises administering ICA-1 or a salt thereof to a subject with glioma. In another embodiment, the treatment method comprises contacting glioma cells with an effective amount of ICA-1 or a salt thereof.
    Type: Application
    Filed: September 4, 2012
    Publication date: March 7, 2013
    Applicants: The U.S Govt. as represented by the Dept. of Veterans Affairs, University of South Florida
    Inventor: Mildred E. Acevedo-Duncan