Abstract: A peptide or peptidomimetic comprising the amino acid sequence of the second helix of a STAT protein, or a variant of such sequence, wherein the peptide or peptidomimetic comprises about 40 or fewer amino acids and binds to a STAT protein, as well as a method of inhibiting a STAT protein in a cell, a method of treating or preventing a disease associated with STAT overexpression in a host, and related compounds, compositions, and methods.
Type:
Application
Filed:
May 30, 2008
Publication date:
July 22, 2010
Applicant:
THE U.S OF AMERICA, AS REPRESENTED BY THE SECRETAR
Inventors:
Nadya I. Tarasova, Olga Timofeeva, Vadim Gaponenko, Christopher J. Michejda, Maria Michejda, Alan O. Perantoni, Sergey G. Tarasov