Patents Assigned to The UAB Research Foundation
  • Patent number: 10391183
    Abstract: A modified adenovirus capable of overcoming the problem of low level of coxsackie-adenovirus receptor (CAR) expression on tumor cells and methods of using such adenovirus are provided. The fiber protein of the adenovirus is modified by insertion or replacement so as to target the adenovirus to tumor cells, and the replication of the modified adenovirus is limited to tumor cells due to specific promoter control or mutations in E1a or E1b genes.
    Type: Grant
    Filed: January 6, 2014
    Date of Patent: August 27, 2019
    Assignees: The UAB Research Foundation, The Board of Regents of the University of Texas System
    Inventors: Juan Fueyo-Margareto, Candelaria Gomez-Manzano, David Curiel
  • Patent number: 10352059
    Abstract: In some embodiments, a shelter includes an impact-resistant panel having an energy-absorbing core positioned between two outer layers, wherein the energy-absorbing core includes a syntactic foam material that has a plurality of hollow microspheres compounded with a polymeric resin.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: July 16, 2019
    Assignee: THE UAB RESEARCH FOUNDATION
    Inventors: Uday Vaidya, Selvum Pillay, Haibin Ning, Krishnan Balaji Thattai Parthasarathy
  • Patent number: 10351532
    Abstract: Provided is a compound of formula (I), in which Ar1, R1, U, V, W, X, and p are as described herein. Also provided are methods of using a compound of formula (I), including a method of treating cancer, a method of treating a patient with cancer cells resistant to an anti-cancer agent, and a method of inhibiting lactate dehydrogenase A (LDHA) and/or lactate dehydrogenase B (LDHB) activity in a cell.
    Type: Grant
    Filed: December 29, 2015
    Date of Patent: July 16, 2019
    Assignees: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, VANDERBILT UNIVERSITY, THE UAB RESEARCH FOUNDATION, THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: David J. Maloney, Alex Gregory Waterson, Ganesh Rai Bantukallu, Kyle Ryan Brimacombe, Plamen Christov, Chi V. Dang, Victor Darley-Usmar, Xin Hu, Ajit Jadhav, Somnath Jana, Kwangho Kim, Jennifer L. Kouznetsova, William J. Moore, Bryan T. Mott, Leonard M. Neckers, Anton Simeonov, Gary Allen Sulikowski, Daniel Jason Urban, Shyh Ming Yang
  • Patent number: 10335448
    Abstract: Provided herein are compositions and methods for treating or preventing fibrosis.
    Type: Grant
    Filed: November 10, 2015
    Date of Patent: July 2, 2019
    Assignee: The UAB Research Foundation
    Inventors: Philip J. O'Reilly, Edwin J. Blalock
  • Patent number: 10322145
    Abstract: The present disclosure is generally related to methods for combining chemotherapy and immunotherapy for the treatment of a cancer. The methods also relate to generating a drug-resistant cytotoxic immune cell line and uses thereof in conjunction with cytotoxic drugs.
    Type: Grant
    Filed: May 21, 2014
    Date of Patent: June 18, 2019
    Assignees: Emory University, The UAB Research Foundation, Children's Healthcare of Atlanta, Inc.
    Inventors: Harold Trent Spencer, Anindya Dasgupta, Lawrence S. Lamb
  • Publication number: 20190175653
    Abstract: The present disclosure is generally related to methods for combining chemotherapy and immunotherapy for the treatment of a cancer.
    Type: Application
    Filed: February 22, 2019
    Publication date: June 13, 2019
    Applicants: Emory University, The UAB Research Foundation
    Inventors: Harold Trent Spencer, Anindya Dasgupta, Lawrence S. Lamb
  • Patent number: 10316100
    Abstract: Provided herein are methods of treating a subject with cancer comprising administering to the subject a death receptor agonist. Also provided herein are methods of screening a breast cancer cell for responsiveness to a DR5 agonist. Further provided herein are antibodies that selectively bind an N-terminal CARD of DDX3, a DDX3 lacking an N-terminal CARD, and an 80 kDa baculovirus TAP repeat (BIR).
    Type: Grant
    Filed: July 20, 2016
    Date of Patent: June 11, 2019
    Assignee: The UAB Research Foundation
    Inventors: Donald J. Buchsbaum, Tong Zhou, Albert F. LoBuglio
  • Patent number: 10300052
    Abstract: The present disclosure provides compounds effective in increasing mucociliary clearance in a subject. In one embodiment, the compounds are of the general formula I. The present disclosure further shows that such compounds are effective in increasing activation of the CFTR, thereby increasing mucociliary clearance in the subject. The present disclosure further shows that such compounds are effective in increasing the depth of ASL, thereby increasing mucociliary clearance in the subject. In one embodiment of each of the foregoing, the subject is free from congenital or genetic defect in the cellular mucociliary clearance apparatus and/or acquired abnormality in the cellular mucociliary clearance apparatus.
    Type: Grant
    Filed: April 28, 2017
    Date of Patent: May 28, 2019
    Assignee: The UAB Research Foundation
    Inventors: Steven M Rowe, Mark Dransfield
  • Patent number: 10302543
    Abstract: The present disclosure provide a method and apparatus for pressure-pulse decay performed on whole cylindrical samples whose entire outer surface areas are eligible to receive the pulse. Using the methods and apparatus of the present disclosure, not only is the experimental time dramatically shortened, it also allows for simultaneous determination of local permeabilities parallel and perpendicular to their native bedding planes. Currently, there is no permeability-measurement technique to capable of doing so from a single sample from a single test.
    Type: Grant
    Filed: May 9, 2016
    Date of Patent: May 28, 2019
    Assignee: The UAB Research Foundation
    Inventor: Michael J Hannon, Jr.
  • Patent number: 10239936
    Abstract: Disclosed are compositions and methods related to variable lymphocyte receptors (VLRs). More particularly, disclosed are a variety of antigen specific polypeptides, including soluble, monoclonal, and multivalent forms, as well as methods of using the polypeptides, antibodies that bind the antigen specific polypeptides, and nucleic acids, vectors and expression systems that encode the polypeptides. Antigen specific polypeptides that selectively bind pathogens, like anthrax, and carbohydrates, like blood group determinants, are specifically disclosed.
    Type: Grant
    Filed: February 25, 2016
    Date of Patent: March 26, 2019
    Assignee: The UAB Research Foundation
    Inventors: Max D. Cooper, Brantley R. Herrin, Matthew N. Alder
  • Patent number: 10220222
    Abstract: In one embodiment, radiotherapy treatment is provided to a target volume of a patient by configuring a multileaf collimator of a radiation treatment machine in a first orientation so as to form an actual aperture having a first orientation, delivering radiation to the target volume through the actual aperture while in the first orientation with a single pass along an arcuate path centered on the target volume, configuring the multileaf collimator in a second orientation so as to place the actual aperture in a second orientation that is different from the first orientation, and delivering radiation to the target volume through the actual aperture while in the second orientation with a single pass back along the arcuate path such that a relatively large cumulative dose of radiation is delivered to the target volume through a virtual aperture created by an area of overlap between the first and second actual aperture orientations.
    Type: Grant
    Filed: July 16, 2015
    Date of Patent: March 5, 2019
    Assignee: UAB RESEARCH FOUNDATION
    Inventor: Richard Popple
  • Publication number: 20190062825
    Abstract: Provided herein are Mycobacterium smegmatis porin nanopores, systems that comprise these nanopores, and methods of using and making these nanopores. Such nanopores may be wild-type MspA porins, mutant MspA porins, wild-type MspA paralog porins, wild-type MspA homolog porins, mutant MspA paralog porins, mutant MspA homolog porins, or single-chain Msp porins. Also provided are bacterial strains capable of inducible Msp porin expression.
    Type: Application
    Filed: June 1, 2018
    Publication date: February 28, 2019
    Applicants: University of Washington, The UAB Research Foundation
    Inventors: Jens H. Gundlach, Michael Niederweis, Thomas Z. Butler, Mikhail Pavlenok, Mark A. Troll, Suja Sukumaran
  • Patent number: 10209254
    Abstract: According to aspects illustrated herein, there are provided a sensor chip suitable for serological detection of Streptococcus pneumoniae, a method for detecting serotypes of Streptococcus pneumoniae using the sensor chip, a detection system that includes the sensor chip, and a method for detecting serotypes of Streptococcus pneumoniae using the detection system described herein.
    Type: Grant
    Filed: October 9, 2014
    Date of Patent: February 19, 2019
    Assignees: University of Rochester, The UAB Research Foundation
    Inventors: Benjamin L. Miller, Moon H. Nahm
  • Patent number: 10188565
    Abstract: In some embodiments, a transport chair includes a base frame, a seat assembly pivotally mounted to the base, and a footrest assembly pivotally mounted to the base frame, the footrest assembly being associated with the seat assembly so as to pivot in unison with the seat assembly until the seat assembly is pivoted forward to an extent at which the footrest assembly contacts the floor or ground, at which point the footrest assembly does not pivot further upon further forward pivoting of the seat assembly.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: January 29, 2019
    Assignee: The UAB Research Foundation
    Inventors: William Ferniany, Lloyd Cooper
  • Patent number: 10181361
    Abstract: Provided herein are methods and systems for image registration from multiple sources. A method for image registration includes rendering a common field of interest that reflects a presence of a plurality of elements, wherein at least one of the elements is a remote element located remotely from another of the elements and updating the common field of interest such that the presence of the at least one of the elements is registered relative to another of the elements.
    Type: Grant
    Filed: May 4, 2017
    Date of Patent: January 15, 2019
    Assignees: Help Lightning, Inc., UAB Research Foundation
    Inventors: Marcus W. Dillavou, Phillip Corey Shum, Barton L. Guthrie, Mahesh B. Shenai, Drew Steven Deaton, Matthew Benton May
  • Patent number: 10167496
    Abstract: Provided herein and methods and kits for identifying inhibitors of SUMOylation. The provided methods include contacting a candidate agent with (i) a SUMO-conjugating peptide comprising an N-terminal linker and a detectable tag, and (ii) a SUMO comprising a metal complex, under conditions that allow binding between the SUMO-conjugating peptide and the SUMO, and detecting the detectable tag thereby determining the level of binding between the SUMO-conjugating peptide and SUMO. A reduced level of binding as compared to the level of binding in the absence of the candidate agent indicating the agent inhibits SUMOylation.
    Type: Grant
    Filed: October 3, 2016
    Date of Patent: January 1, 2019
    Assignee: The UAB Research Foundation
    Inventors: William J. Placzek, Mary-Ann Bjornsti, Christine M. Wright, Robert H. Whitaker
  • Patent number: 10115200
    Abstract: In one embodiment, a method for analyzing sports impacts includes capturing video of game play from multiple locations using video cameras, tracking the heads of players of the games in the video, computing motion parameters of the heads, and determining if one or more of the motion parameters exceeds a threshold established for that parameter.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: October 30, 2018
    Assignee: UAB RESEARCH FOUNDATION
    Inventors: Dean Sicking, Seth Cohen, Dennis Leonard
  • Patent number: 10090665
    Abstract: A method for detecting an open-phase condition of a transformer having a grounded-wye high voltage side connection including monitoring current flowing in a neutral connection on the high voltage side of the transformer in real time by voltage relaying and current relaying to identify an open phase condition signature in a signal capable of characterizing change of current magnitude. A current signal may be injected onto the neutral terminal and the zero-sequence mode of the transformer monitored to detect an open-phase condition indicated by an increase in network impedance and decrease or elimination of the injection current.
    Type: Grant
    Filed: February 21, 2014
    Date of Patent: October 2, 2018
    Assignee: The UAB Research Foundation
    Inventors: Robert F. Arritt, Roger C. Dugan, Wayne E. Johnson, Gregory A. Franklin
  • Patent number: 10080784
    Abstract: The use of a purine nucleoside phosphorylase or nucleoside hydrolase or a vector encoding expression of one of these enzymes is detailed along with the use of a prodrug cleaved by the purine nucleoside phosphorylase or nucleoside hydrolase for the preparation of a direct injection inhibition of replicating or non-replicating targeted cells. The targeted cells do not normally express the introduced purine nucleoside phosphorylase or nucleoside hydrolase. The enzyme and prodrug are amenable to intermixing and injection as a single dose or as separate injection or administration to the targeted cells. The substance and prodrug efficacy are enhanced through exposure of the targeted cells to X-ray radiation. Administration of a prodrug regardless of administration route to the targeted cells is effective in combination with X-ray radiation therapy to kill or inhibit function of the targeted cells.
    Type: Grant
    Filed: February 20, 2012
    Date of Patent: September 25, 2018
    Assignees: SOUTHERN RESEARCH INSTITUTE, THE UAB RESEARCH FOUNDATION
    Inventors: William B. Parker, Eric J. Sorscher
  • Patent number: 10073438
    Abstract: Disclosed are various embodiments for assessing machine trajectories for collision avoidance. A three-dimensional model of a patient based at least in part on data received from a three-dimensional imaging device is generated. The three-dimensional model of the patient is aligned with a coordinate system of a three-dimensional model of a radiation treatment machine. It is then determined whether a collision between the patient and the radiation treatment machine will occur at each one of a series of control points of the radiation treatment plan.
    Type: Grant
    Filed: July 31, 2014
    Date of Patent: September 11, 2018
    Assignee: The UAB Research Foundation
    Inventors: Richard Popple, Rex Cardan