Abstract: The present invention concerns methods and compositions related to type 3 phosphodiesterases (PDE3). Certain embodiments concern isolated peptides corresponding to various PDE3A isoforms and/or site-specific mutants of PDE3A isoforms, along with expression vectors encoding such isoforms or mutants. In specific embodiments, methods for identifying isoform-selective inhibitors or activators of PDE3 are provided, along with methods of use of such inhibitors or activators in the treatment of dilated cardiomyopathy, pulmonary hypertension and/or other medical conditions related to PDE3 effects on cAMP levels in different intracellular compartments.
Type:
Grant
Filed:
March 27, 2014
Date of Patent:
December 6, 2016
Assignees:
The United Sates of America, as Represented by the Department of Veterans Affairs, University of Utah Research Foundation
Abstract: A novel antiproliferative factor comprising a glycopeptide is disclosed. In specific embodiments, the novel antiproliferative factor is associated with the bladder. Compositions, diagnostic kits and reagents, and methods of using the compounds for identifying and/or treating interstitial cystitis and cancer are disclosed.
Type:
Grant
Filed:
December 13, 2007
Date of Patent:
July 21, 2015
Assignees:
University of Maryland, Baltimore, The United States of America as represented by the Secretary of the Department of Health and Human Services, The United Sates of America as Represented by the Department of Veterans Affairs
Inventors:
Susan K. Keay, Zoltan Szekely, Thomas Conrads, Timothy Veenstra, Maria Michejda