Patents Assigned to The United Sates of America, as Represented by the Secretary, Department of Health and Human Service
  • INHIBITORS OF THE FARNESOID X RECEPTOR AND USES IN MEDICINE
    Publication number: 20160159851
    Abstract: Disclosed are inhibitors of the farnesoid X receptor, for example of formula (I), wherein R1, R2, R4, X, Y, Z, m, and n are as defined herein, which are useful in treating or preventing obesity, type 2 diabetes/insulin resistance and non alcoholic fatty liver disease in a mammal in need thereof. Also disclosed is a composition comprising a pharmaceutically suitable carrier and at least Cone compound of the invention, a method of method of inhibiting a farnesoid X receptor in a mammal, and a method of treating or preventing obesity in a mammal.
    Type: Application
    Filed: August 1, 2014
    Publication date: June 9, 2016
    Applicants: The United Sates of America, as represented by the Secretary, Department of Health and Human Service, The Penn State Research Foundation
    Inventors: Frank J. Gonzalez, Changtao Jiang, Cen Xie, Andrew D. Patterson, Fei Li, James B. Mitchell, Shantu Amin, Dhimant Desai
  • INHIBITORS OF VIRAL INTEGRASE AND METHODS OF USE
    Publication number: 20140187477
    Abstract: Described herein are compositions and methods for inhibiting HIV integrase activity. Also described are methods of identifying agents that inhibit HIV integrase for use in treating or preventing HIV. Also disclosed are methods of identifying agents that inhibit HIV viral mutants that are resistant to integrase inhibitors.
    Type: Application
    Filed: March 4, 2014
    Publication date: July 3, 2014
    Applicants: The United Sates of America, as Represented by the Secretary, Department of Health and Human Service, Integratech Proteomics, LLC
    Inventors: Tanya Sandrock, Robert Craigie