Patents Assigned to THE UNITED SSTATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
  • Heterodimers of IL-15 and IL-15R alpha to increase thymic output and to treat lymphopenia
    Patent number: 9975937
    Abstract: The present invention provides method for promoting the maturation and export of T cells from thymic tissue by contacting the thymic tissue with supraphysiological levels of interleukin (IL)-15. The present invention also provides methods for preventing, alleviating, reducing, and/or inhibiting lymphopenia or peripheral depletion of lymphocytes in a patient in need thereof by administering to the patient IL-15.
    Type: Grant
    Filed: October 13, 2014
    Date of Patent: May 22, 2018
    Assignee: THE UNITED SSTATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventors: George N. Pavlakis, Barbara K. Felber, Antonio Valentin, Cristina Bergamaschi