Patents Assigned to The United States Government
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Patent number: 11972050Abstract: Instances of a single brain computer interface (BCI) system can be implemented on multiple devices. An active instance can control the associated device. The instances can each communicate with a neural decoding system that can receive neural signals from a user, process the neural signals, and output a command based on the processed neural signals. A device running the active instance of can be in communication with the neural decoding system to receive a command. The device can include a display, a non-transitory memory storing instructions, and a processor to execute the instructions to: run an instance of a control program; and execute the task based on the command.Type: GrantFiled: November 1, 2022Date of Patent: April 30, 2024Assignees: BROWN UNIVERSITY, THE GENERAL HOSPITAL CORPORATION, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRSInventors: Leigh Hochberg, John D. Simeral, Tyler Singer-Clark, Ronnie Gross, Thomas Hosman, Anastasia Kapitonava, Rekha Crawford
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Patent number: 11957468Abstract: Systems and methods are provided for providing a standardized pressure value representing a transient pressure event within a region of interest within a living body. An air-charged catheter is configured to record pressure data representing the region of interest. A measurement assembly includes a parameter calculation component configured to calculate at least a peak pressure representing the transient pressure event and a time to peak pressure, representing the time necessary to reach the peak pressure, from the recorded pressure data. A standardization component is configured to calculate the standardized pressure value as a function of the peak pressure and the time to peak pressure. A user interface is configured to display at least the standardized pressure value at an associated display.Type: GrantFiled: January 14, 2020Date of Patent: April 16, 2024Assignees: THE CLEVELAND CLINIC FOUNDATION, The United States Government as represented by the Department of Veterans AffairsInventors: Margot S. Damaser, Hassan K. Awada, Paul C. Fletter, Mitchell Cooper, Paul J. Zaszczurynski
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Patent number: 11958786Abstract: A barrier coating system may include a super alloy or ceramic matrix composite (CMC) substrate underneath a bond coat. The barrier coating system may also include a calcium-magnesium aluminosilicate (CMAS) resistant coating configured to protect metallic, or oxide-based or silicon based components in a harsh CMAS environment.Type: GrantFiled: November 28, 2017Date of Patent: April 16, 2024Assignee: UNITED STATES GOVERNMENT ADMINISTRATOR OF NASAInventors: Dongming Zhu, Gustavo Costa
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Patent number: 11951023Abstract: A prosthesis system can comprise an upper arm prosthesis comprising a socket, the upper arm prosthesis being positioned on a first side of the prosthesis system proximate a residual limb of a user. A harness that can be coupled to the socket of the upper arm prosthesis. The harness can comprise a front portion that is configured to extend across the chest of the user and receive at least a portion of the breasts of the user therein and a back portion that is configured to extend across the back of the user and couple to opposed lateral sides of the front portion. A first end of a support strap can couple to the socket of the prosthesis at a first anchor point, and a second end can couple to the back portion of the harness on a second side of the prosthesis system opposite the first side.Type: GrantFiled: December 6, 2021Date of Patent: April 9, 2024Assignee: United States Government As Represented By The Department Of Veterans AffairsInventors: Sandra L. Winkler, Samuel Phillips, Jemy Delikat
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Patent number: 11951136Abstract: Provided herein, inter alia, are methods and compositions for treating diabetes mellitus comprising co-transplantation of an insulin-producing cell and a cell derived from a parathyroid gland (PTG), a CD34+ cell derived from a parathyroid gland, a CD34+ cell derived from a stem cell, or other progenitor cell-derived CD34+ cell.Type: GrantFiled: December 12, 2018Date of Patent: April 9, 2024Assignees: The Regents of the University of California, The United States Government as Represented by the Department of Veterans AffairsInventors: Casey Ward, Qizhi Tang, Peter Stock, Gaetano Faleo, Gopika Nair, Matthias Hebrok, Wenhan Chang, Thuy Vo, Jeffrey A. Bluestone, Eleonora De Klerk
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Patent number: 11951152Abstract: This disclosure is directed to therapeutic compositions, and more particularly to microparticle compositions for the controlled delivery of telmisartan and actinomycin D.Type: GrantFiled: September 18, 2020Date of Patent: April 9, 2024Assignees: University of South Florida, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERAN AFFAIRSInventors: Subhra Mohapatra, Shyam S. Mohapatra, Eleni Markoutsa, Alejandro J. Gonzalez, Heta N. Jadhav
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Patent number: 11945781Abstract: The present disclosure is concerned with thioquinolinone compounds for the treatment of disorders associated with heme oxygenase-1 (HO-1) signaling dysfunction such as, for example, kidney diseases (e.g., chronic kidney disease, acute kidney injury). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: GrantFiled: March 14, 2023Date of Patent: April 2, 2024Assignees: Southern Research Institute, UAB Research Foundation, The United States Government as represented by the Department of Veterans AffairsInventors: Mark J. Suto, Bini Mathew, Anupam Agarwal, Amie M. Traylor
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Patent number: 11944426Abstract: A load cell apparatus includes a base member, a cap member, a number of first members provided between the base member and the cap member and forming at least a portion of a support wall of the load cell apparatus, and a plurality of strain gauges directly coupled to the number of first members, the plurality of strain gauges being positioned to measure an axial load applied to the load cell in a direction extending from the cap member to the base member.Type: GrantFiled: January 11, 2019Date of Patent: April 2, 2024Assignees: University of Pittsburgh-Of the Commonwealth System of Higher Education, The United States Government as Represented by the Department of Veterans AffairsInventors: Jonathan L. Pearlman, Jonathan A. Duvall, Samuel T. Bucior
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Patent number: 11945855Abstract: Recombinant polypeptides comprising a modified DR?1 domain are provided. In some embodiments, the polypeptides include the modified DR?1 domain, an antigenic peptide, and optionally a linker sequence. Pharmaceutical compositions comprising the recombinant polypeptides, methods of treating inflammatory disease using said recombinant polypeptides or pharmaceutical compositions, and expression constructs comprising nucleic acids that encode the recombinant polypeptides are also provided.Type: GrantFiled: October 4, 2019Date of Patent: April 2, 2024Assignees: Oregon Health & Science University, The United States Government as represented by the Department of Veterans AffairsInventors: Roberto Meza-Romero, Arthur A. Vandenbark, Halina Offner
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Patent number: 11939301Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, promote mitochondrial biogenesis and are useful for the treatment of, for example, acute kidney injury and chronic kidney disease.Type: GrantFiled: April 23, 2021Date of Patent: March 26, 2024Assignees: MUSC Foundation for Research Development, The United States Government as Represented by the Department of Veterans AffairsInventors: Christopher C. Lindsey, Craig C. Beeson, Yuri Karl Peterson, Rick G. Schnellmann
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Patent number: 11938045Abstract: Breathable residual-limb system that admits air and allows sweat to evaporate from the surface of the residual limb. In an embodiment, the system comprises a liner sock to be worn on the residual limb, and comprising air-permeable textile forming a substantially cylindrical portion that is closed on a distal end and open on a proximal end and comprising an internal surface and an external surface. The liner sock further comprises a friction-interface material that covers only a portion of the internal surface of the air-permeable textile, such that, when worn on the residual limb, the friction-interface material contacts a surface of the residual limb, and an uncovered portion of the air-permeable textile which the friction-interface material does not cover allows air to pass between an external environment of the liner sock and the surface of the residual limb.Type: GrantFiled: November 23, 2022Date of Patent: March 26, 2024Assignees: United States Government As Represented By The Department Of Veterans Affairs, Fraunhofer-Gesellschaft zur Foerderung der angewandten Forschung e. V.Inventors: Andrew Hansen, Sara Koehler-Mcnicholas, Eric Nickel, Kyle Barrons, Felix Starker, Spencer Mion, John Ferguson, Stuart Fairhurst, Ellankavi Ramasamy, Karl Koester, Urs Schneider
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Patent number: 11935235Abstract: A method of identifying an object of interest can comprise obtaining first samples of an intensity distribution of one or more object of interest, obtaining second samples of an intensity distribution of confounder objects, transforming the first and second samples into an appropriate first space, performing dimension reduction on the transformed first and second samples, whereby the dimension reduction of the transformed first and second samples generates an object detector, transforming one or more of the digital images into the first space, performing dimension reduction on the transformed digital images, whereby the dimension reduction of the transformed digital images generates one or more reduced images, classifying one or more pixels of the one or more reduced images based on a comparison with the object detector, and identifying one or more objects of interest from the classified pixels.Type: GrantFiled: September 1, 2022Date of Patent: March 19, 2024Assignees: UNIVERSITY OF IOWA RESEARCH FOUNDATION, UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRSInventors: Michael Abramoff, Gwenole Quellec
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Publication number: 20240087750Abstract: h A method for using a trained machine learning model to predict risk of incident opioid use disorder (OUD) and/or of N an opioid overdose episode for a subject. The method comprises using at least one computer hardware processor to perform: accessing data associated with the subject, wherein the data comprises values for a plurality of predictors; generating input features for the trained machine learning model from the data; and providing the input features as input to the trained machine learning model to obtain an output indicative of the risk of OUD and/or of the opioid overdose episode for the subject, wherein the trained machine learning model comprises a first plurality of values for a respective first plurality of parameters, the first plurality of values used by the at least one computer hardware processor to obtain the output from the input features.Type: ApplicationFiled: June 17, 2021Publication date: March 14, 2024Applicants: University of Florida Research Foundation, Incorporated, University of Pittsburgh- Of the Commonwealth System of Higher Education, The United States Government as represented by The Department of Veterans AffairsInventors: Wei Hsuan Lo Ciganic, Walid Fouad Gellad
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Patent number: 11925611Abstract: The present disclosure is concerned with substituted N-(5-chloro-4-((4-chlorophenyl)(cyano)methyl)-2-methylphenyl)benzamide compounds, and methods of treating and/or preventing neurodegenerative or neurocognitive disorders including, but not limited to, Alzheimer's disease, cerebral autosomal dominant arteriopathy with sub-cortical infarcts and leukoencephalopathy (CADASIL), Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis (ALS/Lou Gehrig's disease), Multiple Sclerosis, spinal muscular atrophy, spinal and bulbar muscular atrophy, familial spastic paraparesis, Machado Joseph disease, Friedreich's ataxia, Lewy body disease, and dementia (e.g., vascular dementia, Lewy body dementia, frontotemporal dementia, mixed dementia, dementia induced by Alzheimer's disease or Parkinson's disease). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: GrantFiled: March 25, 2022Date of Patent: March 12, 2024Assignees: United States Government as represented by the Department of Veterans Affairs, University of Pittsburgh - of the Commonwealth of Higher EducationInventors: Dandan Sun, Mohammad Iqbal Hossain Bhuiyan
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Patent number: 11921118Abstract: Provided herein are methods for labeling the proteomes of cells, as well as methods for labeling proteins or populations of proteins produced by cells. In some embodiments, the methods comprise introducing variant aminoacyl-tRNA synthetases and noncanonical amino acids into cells. Also provided herein are polynucleotides encoding variant aminoacyl-tRNA synthetases that recognize noncanonical amino acids. The methods and compositions provided herein are useful for, among other things, identifying target cells and identifying biomarkers of interest.Type: GrantFiled: November 5, 2020Date of Patent: March 5, 2024Assignees: The Board of Trustees of the Leland Stanford Junior University, The United States Government as represented by the Department of Veterans AffairsInventors: Andrew Yang, Anton Wyss-Coray, Kyle Brewer
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Patent number: 11912998Abstract: Methods of treating an adult mammal for an aging-associated impairment are provided. Aspects of the methods include modulating CCR3, e.g., by modulating eotaxin-1/CCR3 interaction, in the mammal in a manner sufficient to treat the mammal for the aging-associated impairment. A variety of aging-associated impairments may be treated by practice of the methods, which impairments include cognitive impairments.Type: GrantFiled: December 14, 2021Date of Patent: February 27, 2024Assignees: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRSInventors: Anton Wyss-Coray, Thomas A. Rando, Markus Britschgi, Kaspar Rufibach, Saul A. Villeda
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Patent number: 11911487Abstract: The present invention provides methods and materials useful delivering liquids, including liquids comprising nucleic acid molecules into cells. In particular, the present invention provides methods for delivering saline solution, exogenous compositions, and isolated vectors to kidney cells, using the renal vein as a guide and under hydrodynamic pressure. The delivery methods and materials herein are useful to research, prognose, ameliorate symptoms of kidney injury, and treat kidney pathologies.Type: GrantFiled: May 3, 2013Date of Patent: February 27, 2024Assignees: Indiana University Research and Technology Corporation, United States Government as Represented by the Department of Veterans AffairsInventors: Robert Bacallao, Simon Atkinson, George Rhodes, Peter Corridon
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Patent number: 11912078Abstract: The innovation presented herein provides among its embodiments, a non-pneumatic structure such as a vehicle tire, consisting of a matrix of shape memory alloy (SMA) elements. The interlocking layering pattern provides geometries which leverage the SMA material properties to accomplish performance characteristics of traditional pneumatic structures across a spectrum of possible desired uses including normal personal use, recreational use, sport use and commercial use. Embodiments include applying structural design and material properties to provide a fixed or a variable set of performance characteristics. Similar to the fruits of other space program initiatives, the innovation leverages material science developed for extra-terrestrial purposes to accomplish advances over conventional items.Type: GrantFiled: December 11, 2020Date of Patent: February 27, 2024Assignee: United States Government Administrator of NASAInventors: Colin M. Creager, Santo A. Padula, II, Calvin Young
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Patent number: 11911481Abstract: This invention provides for a RSV-targeted nanoparticle PMN (RTPMN), combining HR2D anti-fusion peptide, and plasmid encoded siRNA against RSV-NS1 and/or RSV-P gene as a safe, effective and inexpensive anti-RSV prophylaxis and/or therapy.Type: GrantFiled: May 21, 2019Date of Patent: February 27, 2024Assignees: UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS, UNIVERSITY OF SOUTH FLORIDAInventors: Eleni Markoutsa, Subhra Mohapatra, Shyam Mohapatra
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Patent number: 11903806Abstract: An artificial urinary sphincter can include a cuff configured to surround a portion of a length of a urethra. An actuator is configured to selectively apply a force to the cuff to thereby apply variable amount of pressure to the urethra. A controller is configured to adjust the application of the force by the actuator to cause the cuff to apply the variable amount of pressure to the urethra. A sensor can be in communication with the controller and configured to detect pressure applied against the cuff by the urethra. The controller is configured to cause the cuff to apply a first closing pressure to the urethra. In response to a detection of a threshold pressure increase by the sensor, the controller is configured to cause the cuff to apply a second closing pressure that is greater than the first closing pressure and that prevents urine from exiting the urethra.Type: GrantFiled: March 1, 2019Date of Patent: February 20, 2024Assignees: United States Government As Represented By The Department Of Veterans Affairs, Wayne State University, University of BaselInventors: Nivedita Dhar, Steven Majerus, Jeremy Rickli, Tino Toepper, Bekim Osmani, Bert Mueller