Patents Assigned to The United States Government as represented by the Department of Veterans Affairs
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Patent number: 12233527Abstract: An adaptive holder is used to provide those lacking fine hand motor control skills and limited arm and shoulder range of motion with the ability to conveniently extend and orient utensils such as forks and spoons. Used with a universal adapter cuff, the holder includes a slotted head which receives the utensil handle. A gripping portion, attached to the head, is received by the cuff. The utensil may be angularly oriented relative to the head and is secured thereto by a frictional interference fit.Type: GrantFiled: July 8, 2022Date of Patent: February 25, 2025Assignee: THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRSInventors: Brian Burkhardt, Seth Hills, John Miller, Melissa Oliver
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Patent number: 12233180Abstract: The invention provides method for organizing the disinfection of one or more items contaminated with biological agent(s) comprising (a) attaching a radio-frequency ID (RFID) tag to an item(s) to be disinfected; exposing the item(s) of (a) to a disinfecting means for a period sufficient to disinfect the item; and (c) obtaining a signal from the tagged item when disinfection is complete thereby organizing the disinfection of one or more items.Type: GrantFiled: August 19, 2022Date of Patent: February 25, 2025Assignee: The United States Government as represented by the Department of Veterans AffairsInventor: Chetan Jinadatha
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Patent number: 12233189Abstract: An artificial lung system for a patient having a membrane lung system having an gas inlet, a blood inlet, a blood outlet, and an exhaust; a gas system operably coupled to the gas inlet of the membrane lung system; a gas phase CO2 sensor disposed downstream of the exhaust of the membrane lung system and monitoring an exhaust gas CO2 (EGCO2) level and/or an blood oxygen saturation sensor disposed upstream of the blood inlet of the membrane lung system and monitoring a blood oxygen saturation level; and a feedback controller receiving the CO2 signal and/or blood oxygen saturation signal and outputting a control signal to control gas flow and/or blood flow.Type: GrantFiled: June 18, 2019Date of Patent: February 25, 2025Assignees: The Regents of The University of Michigan, United States Government As Represented by the Department of Veterans AffairsInventors: Joseph Potkay, Robert H. Bartlett, Alvaro Rojas-Pena
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Publication number: 20250057486Abstract: A method for detecting, diagnosing or screening for cognitive impairment in a subject includes a) positioning the subject in front of a screen, b) displaying a video to the subject on the screen, the video including a target that moves around a predefined closed perimeter of the screen, the target forming at least one revolution on the screen around the closed perimeter, c) tracking eye movement of at least one eye of the subject as the subject watches the video, d) analyzing eye movement of at least one eye of the subject, e) calculating a statistical test for eye movement of at least one eye of the subject as compared to a normal or mean eye movement, f) detecting, diagnosing or screening for an impairment based on the calculated statistical test, and g) providing a suitable clinical intervention based on the calculated statistical test.Type: ApplicationFiled: November 5, 2024Publication date: February 20, 2025Applicants: THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS, NEW YORK UNIVERSITYInventor: Uzma Samadani
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Patent number: 12226423Abstract: Compositions comprising 5-cholesten-3, 25-diol, 3-sulfate (25HC3S) or pharmaceutically acceptable salt thereof and at least one cyclic oligosaccharide, e.g., a cyclodextrin (CD), are provided. The compositions may be used to prevent and/or treat a variety of diseases and conditions, including organ failure (e.g. acute liver failure), high cholesterol/high lipids, and various inflammatory diseases and conditions.Type: GrantFiled: June 28, 2022Date of Patent: February 18, 2025Assignees: Virginia Commonwealth University, Durect Corporation, The United States Government as Represented by The Department of Veterans AffairsInventors: Shunlin Ren, Leyuan Xu, Yanxia Ning, Jin Koung Kim, WeiQi Lin, Andrew R. Miksztal, Hongwei Wu, Min L. Lee
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Patent number: 12227479Abstract: A genus of dihydropyridine chemical modulators of synaptojanin is disclosed. These modulators are selective inhibitors of synaptojanin 1 and may be used to treat cognitive impairment or traumatic brain injury, including promoting regeneration in cases of traumatic brain injury, or for treating neurodegenerative disorders.Type: GrantFiled: October 10, 2022Date of Patent: February 18, 2025Assignees: The United States Government as represented by the Department of Veterans Affairs, Icahn School of Medicine at Mount SinaiInventors: Michael Ohlmeyer, Dongming Cai
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Patent number: 12220247Abstract: A portable polysomnography apparatus comprises a unitary flexible structured pillow that is embedded with one or more sensors for data collection. The one or more sensors can comprise a tilt sensor that is configured to generate respiratory effort signals based on tilting of the head of the subject on the pillow. The one or more sensors can further be configured to generate ballistocardiogram signals from movement of the head of the subject caused by beating of the heart of the subject. The polysomnography apparatus can be advantageously sized and shaped to cause the sleeping subject to properly orient her head with respect to the sensors for optimal data collection while the subject is asleep.Type: GrantFiled: September 22, 2023Date of Patent: February 11, 2025Assignee: United States Government As Represented By The Department Of Veterans AffairsInventor: Steven Hartwell Woodward
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Patent number: 12215108Abstract: The present disclosure is concerned with purine diamine compounds for the treatment of conditions associated with BRD4, RIP3K, and/or IL6 signaling dysfunction such as, for example, cancer (e.g., lung cancer, skin cancer, bladder cancer, kidney cancer, liver cancer), arsenicosis, arsenic poisoning, inflammation, skin lesions, dysfunction of systemic organs, and skin blisters. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: GrantFiled: January 10, 2023Date of Patent: February 4, 2025Assignees: Southern Research Institute, UAB Research Foundation, The United States Government as represented by the Department of Veterans AffairsInventors: Mark J. Suto, Bini Mathew, Corinne E. Augelli-Szafran, Marina Fosso Yatchang, Mohammad Athar, Anupam Agarwal, Ritesh Kumar Srivastava, Suhail Muzaffar, Jasim Khan
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Patent number: 12208857Abstract: Hand pedals for turning the crank set of an arm driven tricycle have modular interchangeable components including a bearing which mounts on the spindle of the crank. A bridge connects the bearing to a handle. The bridge has two legs connected by a transverse spar. Different bridges and handles may be used having different sizes, shapes, lengths and angular orientations which allow the hand pedals to be customized to accommodate a particular user. Hand pedals may also be used on hand cranked bicycles, stationary hand cranked bicycles and industrial equipment.Type: GrantFiled: May 12, 2020Date of Patent: January 28, 2025Assignees: United States Government as represented by the Department of Veterans Affairs, University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Rory A. Cooper, Benjamin Gebrosky
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Patent number: 12201579Abstract: As an example, a walker includes a first leg pair, a second leg pair and a cross beam connecting the first and second leg pairs in a parallel, spaced apart relationship. Each leg pair includes a U-shaped tube defining a front leg and a rear leg. A front strut is telescopically movable within the front leg and extends outwardly therefrom. A rear strut is telescopically movable within the rear leg and extends outwardly therefrom. A mechanical linear actuator includes a rotating element adapted to rotate relative to at least one of the front leg or the rear leg. The rotating element includes an interface with a track on the respective strut relative to which the rotating element rotates, whereby rotational motion of the rotating element translates to corresponding linear motion of the strut.Type: GrantFiled: June 7, 2023Date of Patent: January 21, 2025Assignees: The United States Government As Represented By The Department Of Veterans Affairs, Case Western Reserve UniversityInventors: Ronald J. Triolo, Marc Louis Vitantonio, Robert Craig Allen, Shawn William Dellinger, Anna E. Krakora
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Patent number: 12201361Abstract: A system includes an eye tracker having a camera, the eye tracker being configured and arranged to track an eye movement of a subject, and a processor in communication with the eye tracker, the processor being configured and arranged to create a dataset of the eye movement, generate a plot of the dataset, the plot reflecting a timecourse of eye position versus time, and identify one or more streaking vertical lines in the plot to indicate a deficit in cranial nerve II function.Type: GrantFiled: March 17, 2022Date of Patent: January 21, 2025Assignees: NEW YORK UNIVERSITY, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERAN AFFAIRSInventors: Uzma Samadani, Shani Offen, Marisa Carrasco-Queijeiro, David Heeger
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Patent number: 12201842Abstract: A neural stimulation and recording electrode assembly includes a selectively deformable guide tube. The guide tube includes a plurality of sequentially coupled connecting structures, wherein each connecting structure of the plurality of connecting structures has a respective central axis, and wherein at least one of the plurality of connecting structures is selectively deformable relative to the central axis of a sequential connecting structure of the plurality of connecting structures such that the central axis of the selectively deformable connecting structure is angularly oriented relative to the central axis of the sequential connecting structure.Type: GrantFiled: June 24, 2022Date of Patent: January 21, 2025Assignee: United States Government As Represented By The Department Of Veterans AffairsInventor: Arash Hadipour-Niktarash
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Patent number: 12193741Abstract: An example method includes establishing a wireless link between a mobile device and an optical coherence tomography (OCT) test system, which includes a wireless interface. The method also includes executing an application on the mobile device to present a graphical user interface on a display of the mobile device. The method also includes sending instructions from the mobile device through the wireless link to activate the OCT test system to record OCT measurements for an OCT scan of at least one eye. The method also includes receiving OCT test data at the mobile device from the OCT test system through the wireless link. The OCT test data can represent the OCT measurements recorded by the OCT test system for the OCT scan of the at least one eye.Type: GrantFiled: June 3, 2021Date of Patent: January 14, 2025Assignees: CASE WESTERN RESERVE UNIVERSITY, UNIVERSITY HOSPITALS CLEVELAND MEDICAL CENTER, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERAN AFFAIRSInventors: Warren M. Sobol, Alan Dogan, Ellis Saupe
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Patent number: 12186212Abstract: Technology is described to provide a foot and ankle prosthesis for individuals with lower limb loss. This technology is able to store and release energy and individuals or patients who are using the foot/ankle prosthesis may be able to expend less energy when walking. The system includes a hydraulic damper attached to dynamic energy storing spring elements. The axis of rotation of the system can be near to that of an intact human ankle, providing biomimetic function. The system can utilize spring elements based on the vertical displacement of the center of pressure of an intact normal foot. A hydraulic system can provide user adjustable heel height and adaptation to inclines. The dorsiflexion and plantar flexion resistances can be independently adjusted manually or electrically. In addition, the system can be automatically locked in dorsiflexion when loaded and unlock when unloaded.Type: GrantFiled: October 21, 2021Date of Patent: January 7, 2025Assignees: Motion Control, The United States Government As Represented by the Department Of Veterans AffairsInventors: Andrew Howard Hansen, Edwin Kay Iversen, Eric Alexander Nickel, Gregory O. Voss, Gregory James Jacobs, Carter J. Greene, Jeffery David Christenson
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Patent number: 12178626Abstract: The present invention provides an encapsulated gas or partial vacuum particle contrast media for use in CT imaging. In an exemplary embodiment, the invention provides an enteric contrast medium formulation. An exemplary formulation comprises, (a) an enteric contrast medium comprising a encapsulated gas or partial vacuum particle suspended in water. Exemplary encapsulated gas or partial vacuum particle has a specific gravity between 0.2 and 1.5. In various embodiments, the encapsulated gas or partial vacuum particle is suspended in aqueous media by an agent compatible with enteric administration of the formulation to a subject in need of such administration. In an exemplary embodiment, the contrast material is incorporated into a pharmaceutically acceptable carrier in which the material is suspended homogeneously. In an exemplary embodiment, the encapsulated gas or partial vacuum particle comprises 5% or more of the weight of the contrast material formulation.Type: GrantFiled: September 13, 2021Date of Patent: December 31, 2024Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE UNITED STATES GOVERNMENT as represented by THE DEPARTMENT OF VETERANS AFFAIRSInventors: Benjamin M. Yeh, Yanjun Fu
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Patent number: 12173314Abstract: Methods are provided for the cell-based delivery of collagen VII for the treatment of Epidermolysis Bullosa and corneal erosion. The disclosure also provides a composition and a pharmaceutical composition comprises, comprise, or alternatively consist essentially of, or yet further consist of a keratinocyte sheet or a corneal cell sheet.Type: GrantFiled: January 3, 2017Date of Patent: December 24, 2024Assignees: The Board of Trustees of the Leland Stanford Junior University, The United States Government as represented by the Department of Veterans AffairsInventors: Zurab Siprashvili, Ngon T. Nguyen, M. Peter Marinkovich, Jean Tang, Alfred T. Lane, Paul A. Khavari
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Publication number: 20240409667Abstract: Methods of treating neuroinflammation in a subject by administering to the subject an agent that inhibits activation of coagulation factor XI (FXI), inhibits the activity of activated FXI (FXIa), or reduces expression of FXI are described. The agent that inhibits activation of FXI can be a monoclonal antibody specific for FXI, such as a monoclonal antibody having the complementarity determining region (CDR) sequences of anti-FXI antibody 14E11. Small molecule inhibitors and antisense compounds directed to FXI or FXIa are also contemplated as agents that inhibit activity of FXIa or reduce expression of FXI. The neuroinflammation in the subject can be associated with any one of a number of different diseases or disorders, such as an autoimmune disease of the central nervous system (CNS) or a neurodegenerative disease.Type: ApplicationFiled: June 4, 2024Publication date: December 12, 2024Applicants: Oregon Health & Science University, The United States Government as represented by the Department of Veterans AffairsInventors: Owen McCarty, Erik Tucker, Norah Verbout, Halina Offner, Tia Kohs
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Patent number: 12161655Abstract: The present invention provides methods of treating mycobacterial infections or mycobacterial diseases by administering a tetracycline compound, e.g., omadacycline, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: September 3, 2019Date of Patent: December 10, 2024Assignees: Paratek Pharmaceuticals, Inc., The United States Government as represented by the Department of Veterans AffairsInventors: Michael Henry Cynamon, Michael P. Draper, Judith N. Steenbergen, S. Ken Tanaka
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Patent number: 12162818Abstract: The present disclosure provides compounds of Formula (VIIb) and methods for inhibiting or degrading the N-terminal domain of the androgen receptor, as well as methods for treating cancers such as prostate cancer.Type: GrantFiled: January 13, 2022Date of Patent: December 10, 2024Assignees: The Regents of the University of California, The United States Government represented by the Department of Veterans AffairsInventors: Matthew Rettig, Michael E. Jung, D. Elshan Nakath G. Ralalage, Jiabin An
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Patent number: D1061262Type: GrantFiled: December 22, 2022Date of Patent: February 11, 2025Assignee: UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRSInventors: Rebecca Gallo, Cynthia Rice, Colin Kenow, Soleil Bornstein