Patents Assigned to The United States Government as represented by the Department of Veterans Affairs
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Publication number: 20220331517Abstract: Syringe pump controllers which memorialize the process of hydrodynamic isotonic saline delivery (HIFD) to reverse acute kidney injury are disclosed. In some embodiments, the syringe pump controllers are constructed to control syringe pump(s) to deliver a defined volume of saline at a prescribed perfusion rate while monitoring renal vein pressures during the infusion. In some embodiments, the syringe pump controllers have safety features designed to shut off the infusion if the renal vein pressure goes above set safety limits.Type: ApplicationFiled: September 17, 2020Publication date: October 20, 2022Applicants: The Trustees of Indiana University, The United States Government as represented by the Department of Veterans AffairsInventors: Mark S. Carlsen, Gregory S. Eakins, Robert M. Everly, Catherine L. McIntyre, Phillip J. Wyss, Robert L. Bacallao
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Patent number: 11468794Abstract: A training manikin can have a front, a longitudinal axis, and a sagittal axis perpendicular to the longitudinal axis. The training manikin can comprise a head portion having an oral aperture. A simulated esophagus can be in communication with the oral aperture of the head portion. The simulated esophagus can be configured to receive a gastrointestinal tube. A simulated larynx can be positioned between the simulated esophagus and the front of the manikin relative to the sagittal axis. A reservoir can be configured to receive a liquid. A conduit in communication with the reservoir, can have an outlet end that is positioned proximate to the oral aperture of the head portion. A pump can be positioned between, and in communication with, the reservoir and the conduit and configured to begin pumping the liquid from the reservoir to the outlet end of the conduit upon a first condition.Type: GrantFiled: October 30, 2020Date of Patent: October 11, 2022Assignee: United States Government as Represented by the Department of Veterans AffairsInventors: Jorge Lara-Gutierrez, Patrick Martino, Eric A. Heckenbach, Mary Ellen Elias, Dave Sullivan
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Patent number: 11465972Abstract: Inhibitors of oxidized low-density lipoprotein receptor 1 (LOX-1), compositions comprising inhibitors of LOX-1, and methods of using thereof are described.Type: GrantFiled: December 19, 2019Date of Patent: October 11, 2022Assignees: THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS, BIOVENTURES, LLCInventors: Jawahar L. Mehta, Magomed Khaidakov, Kottayil I. Varughese, Shraddha Thakkar, Yao Dai, Peter Crooks, Narsimha Reddy Penthala
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Patent number: 11468558Abstract: A method of identifying an object of interest can comprise obtaining first samples of an intensity distribution of one or more object of interest, obtaining second samples of an intensity distribution of confounder objects, transforming the first and second samples into an appropriate first space, performing dimension reduction on the transformed first and second samples, whereby the dimension reduction of the transformed first and second samples generates an object detector, transforming one or more of the digital images into the first space, performing dimension reduction on the transformed digital images, whereby the dimension reduction of the transformed digital images generates one or more reduced images, classifying one or more pixels of the one or more reduced images based on a comparison with the object detector, and identifying one or more objects of interest from the classified pixels.Type: GrantFiled: October 11, 2018Date of Patent: October 11, 2022Assignees: UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS, UNIVERSITY OF IOWA RESEARCH FOUNDATIONInventors: Michael Abramoff, Gwenole Quellec
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Patent number: 11458309Abstract: Provided are devices and methods for providing a flexible implantable tissue stimulator. A flexible implantable tissue stimulator can be use in a variety of medical/surgical procedures, and therapeutic interventions, such as musculoskeletal stimulation therapy. The flexible implantable tissue stimulator can be implanted via a minimally invasive procedure and comprises a biocompatible flexible construction that enables it to conform to a variety of implantation orientations and biological conditions. The flexible implantable tissue can provide programmable biphasic electrical stimulation to impaired tissue, such as a gluteal muscle.Type: GrantFiled: September 19, 2018Date of Patent: October 4, 2022Assignees: United States Government as Represented by the Department of Veterans Affairs, Case Western Reserve UniversityInventors: Christian Zorman, Douglas Shire, David Keicher, Katherine M. Bogie
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Patent number: 11453725Abstract: The invention provides methods for selective targeting of live cells, which have undergone or are undergoing radiation or chemotherapy, at a site of interest with a cell-penetrating polypeptide. In one embodiment of the invention, the method comprises contacting the live cells with a cell-penetrating polypeptide comprising cell-penetrating determinants so that the cell-penetrating polypeptide binds extracellular DNA near or around the live cells so as to form a complex or association therewith such that the complex or associated polypeptide-DNA so bound bind the live cells and penetrates the live cells thereby selectively targeting live cells at a site of interest with a cell-penetrating polypeptide.Type: GrantFiled: August 19, 2019Date of Patent: September 27, 2022Assignee: THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRSInventors: Richard H. Weisbart, Robert N. Nishimura
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Patent number: 11446331Abstract: The present invention is directed to wound healing scaffolds cografted with a population of stem cells, wherein the population of stem cells are ABCB5+ stem cells. The scaffolds are, for instance, collagen glycosaminoglycan scaffolds.Type: GrantFiled: May 9, 2014Date of Patent: September 20, 2022Assignees: The Brigham and Women's Hospital, Inc., Children's Medical Center Corporation, The United States Government as Represented by the Department of Veterans AffairsInventors: Markus H. Frank, Natasha Y. Frank, Dennis P. Orgill, George F. Murphy
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Patent number: 11439658Abstract: Described herein are compositions and methods for treating Alzheimer's disease or dementia. The compositions include mammalian suppressor of taupathy 2 inhibitors (MSUT2). The MSUT2 inhibitors can be small interfering RNAs, guide RNAs, or small molecules. The methods include reducing accumulation of phosphorylated and aggregated human tau.Type: GrantFiled: April 12, 2019Date of Patent: September 13, 2022Assignees: United States Government As Represented By The Department Of Veterans Affairs, University of WashingtonInventors: Brian Kraemer, Jeanna M. Wheeler, Pamela McMillan, Timothy J. Strovas, Jeremy Baker
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Publication number: 20220280609Abstract: The present disclosure relates, in general, to methods for treating cancer comprising administering to a subject in need thereof an effective amount of CXCL9, CXCL10 or the combination, in combination with an immune checkpoint inhibitor. The CXCL9, CXCL10 or combination may be administered as a polypeptide, a polynucleotide or cells comprising a polynucleotide encoding CXCL9, CXCL10 or both. In one aspect, the treatment is amenable to patients with low or high mutational burden tumors.Type: ApplicationFiled: July 17, 2020Publication date: September 8, 2022Applicants: The Regents of the University of California, United States Government Represented by the Department of Veterans AffairsInventors: Steven M. DUBINETT, Bin LIU, Raymond LIM, Ramin SALEHI-RAD
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Publication number: 20220280535Abstract: The invention provides a method for (a) increasing skeletal muscle mass; (b) reducing skeletal muscle atrophy; (c) increasing muscular strength; (d) promoting muscle growth; (e) decreasing muscle wasting; or (f) increasing strength per unit of muscle mass in an animal identified or having been identified to be in need of one or more of (a)-(f), the method comprising administering to the animal an effective amount of a compound of formula: or a stereoisomer, solvate, or pharmaceutically acceptable salt thereof, thereby accomplishing one or more of (a)-(f).Type: ApplicationFiled: May 17, 2021Publication date: September 8, 2022Applicants: UNIVERSITY OF IOWA RESEARCH FOUNDATION, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRSInventors: Christopher M. ADAMS, Steven D. KUNKEL, Michael WELSH
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Patent number: 11432948Abstract: A device and method for managing a plurality of groups of socks where the device includes a plurality of pouches attached to one another and a patient education and compliance tool. Each group has at least one sock. Socks of each of the groups have different characteristics from one another. The groups of socks are adapted for use between a limb of a patent and a socket of a prosthetic device. Each pouch is adapted for securing at least one sock from a group. The method includes sorting the plurality of groups of socks according to the characteristic, associating each pouch with a respective one of the groups, and securing each group of socks within an associated pouch.Type: GrantFiled: June 25, 2019Date of Patent: September 6, 2022Assignee: United States Government as represented by the Department of Veterans AffairInventor: Billie Caris Savvas Slater
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Publication number: 20220267312Abstract: Provided herein are compounds of the formula: wherein the variables are as defined herein. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds may be used for the treatment of diseases or disorders, such as an infection of an antibiotic resistant bacteria.Type: ApplicationFiled: January 19, 2022Publication date: August 25, 2022Applicants: Saint Louis University, United States Government as Represented by the Department of Veterans AffairsInventors: John K. WALKER, Feng CAO, Terri BOEHM, Kinthada RAMAKUMAR
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Patent number: 11419533Abstract: The present disclosure relates generally to using detected bladder events for the diagnosis of urinary incontinence or the treatment of lower urinary tract dysfunction. A system includes a sensing device comprising a pressure sensor to directly detect a pressure within a bladder. The sensing device is adapted to be located within the bladder. The system also includes a signal processing device to: receive a signal indicating the detected pressure within the bladder; detect a bladder event based the detected pressure within the signal; and characterize the bladder event as a bladder contraction event or a non-contraction event. The characterization of the bladder event can be used in the diagnosis of urinary incontinence or the treatment of lower urinary tract dysfunction.Type: GrantFiled: March 21, 2019Date of Patent: August 23, 2022Assignees: THE CLEVELAND CLINIC FOUNDATION, The United States Government as represented by the Department of Veterans Affairs, Case Western Reserve UniversityInventors: Margot S. Damaser, Swarup Bhunia, Robert Karam, Steve Majerus, Dennis Bourbeau, Hui Zhu
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Patent number: 11419772Abstract: A system and method for improving stability of a wheelchair user includes a wheelchair having sensors measuring motion parameters to sense collisions and sharp turns which may unseat the user. Neuromuscular stimulating electrodes attached to extensor and flexor muscles of the user's trunk and under the command of a controller in communication with the sensors activate the muscles during turns and collisions to counteract the forces induced. A system and method for increasing manual propulsion efficiency includes sensors for sensing motion parameters indicating completion of a manual push of the wheelchair wheels and recovery from the push. Neuromuscular stimulating electrodes attached to extensor and flexor muscles of the user's trunk and under the command of a controller in communication with the sensors activate the muscles at the appropriate time in the cycle of push and recovery.Type: GrantFiled: August 7, 2018Date of Patent: August 23, 2022Assignee: United States Government as represented by the Department of Veterans AffairsInventors: Ronald J. Triolo, Stephanie Bailey, Kevin M. Foglyano, Kiley Armstrong, Musa L. Audu
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Patent number: 11414379Abstract: The present disclosure is concerned with N-(5-chloro-4-((4-chlorophenyl)(cyano)methyl)-2-methylphenyl)benzamide compounds that are capable of inhibiting SPAK kinase function, methods of treating hypoxic brain injuries due to, for example, ischemic stroke. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: GrantFiled: February 16, 2021Date of Patent: August 16, 2022Assignees: UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS, UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH OF HIGHER EDUCATION, XIAMAN UNIVERSITY, UNIVERSITY OF EXETERInventors: Dandan Sun, Xianming Deng, Jinwei Zhang, Mohammad Iqbal Hossain Bhuiyan, Bradley J. Molyneaux
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Publication number: 20220251162Abstract: In certain embodiments novel PAC1 receptor agonists are provided wherein the agonists comprise a targeting sequence that binds to the PAC1 receptor and said targeting sequence is attached to an amino acid sequence comprising a fragment of the maxadilan amino acid sequence, wherein the targeting sequence comprises a full-length 38 amino acid PACAP peptide or an N-terminus fragment thereof containing the amino acid sequence HSDGIF, wherein said targeting sequence optionally comprises an amino acid insertion between residues 11 and 12 of said PACAP peptide or fragment thereof; and the fragment of the maxadilan amino acid sequence comprises a fragment of the maxadilan sequence effective to activate PAC1 signaling.Type: ApplicationFiled: October 25, 2021Publication date: August 11, 2022Applicants: The Regents of the University of California, The United States Government Represented by The Department Of Veterans AffairsInventors: Joseph R. Pisegna, Patrizia M. Germano, John P. Vu
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Patent number: 11406646Abstract: Compositions comprising 5-cholesten-3,25-diol, 3-sulfate (25HC3S) or pharmaceutically acceptable salt thereof and at least one cyclic oligosaccharide, e.g., a cyclodextrin (CD), are provided. The compositions may be used to prevent and/or treat a variety of diseases and conditions, including organ failure (e.g. acute liver failure), high cholesterol/high lipids, and various inflammatory diseases and conditions.Type: GrantFiled: November 10, 2020Date of Patent: August 9, 2022Assignees: Virginia Commonwealth University, Durect Corporation, The United States Government as Represented by The Department of Veterans AffairsInventors: Shunlin Ren, Leyuan Xu, Yanxia Ning, Jin Koung Kim, WeiQi Lin, Andrew R. Miksztal, Hongwei Wu, Min L. Lee
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Patent number: 11408844Abstract: As one example, an apparatus includes a dielectric microsensor comprising a microfluidic chamber that includes a capacitive sensing structure, the microfluidic chamber including a fluid input port to receive a volume of a blood sample. A bioactive agent is disposed within the chamber to interact with the volume of the blood sample received in the microfluidic chamber. A transmitter provides an input radio frequency (RF) signal to an RF input of the dielectric microsensor. A receiver receives an output RF signal from an RF output of the dielectric microsensor. A computing device that computes dielectric permittivity values of the sample that vary over a time interval based on the output RF signal, the computing device to provide an assessment of hemostatic dysfunction and associated coagulopathy based on the dielectric permittivity values.Type: GrantFiled: April 1, 2020Date of Patent: August 9, 2022Assignees: CASE WESTERN RESERVE UNIVERSITY, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERAN AFFAIRS, UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATIONInventors: Michael Suster, Pedram Mohseni, Anirban Sen Gupta, Matthew David Neal, Ujjal Didar Singh Sekhon, Sanjay Pitamber Ahuja, Sina Pourang, Debnath Maji
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Patent number: D959672Type: GrantFiled: January 11, 2021Date of Patent: August 2, 2022Assignee: United States Government as represented by the Department of Veterans AffairsInventor: Cassidy Rae Bartlett
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Patent number: D967101Type: GrantFiled: July 31, 2020Date of Patent: October 18, 2022Assignees: United States Government as represented by the Department of Veterans Affairs, University of Pittsburgh—Of The Commonwealth System of Higher EducationInventors: Rory A. Cooper, Garrett G. Grindle, Zachary Kitzmiller Anzelone, Aaron Tyler Anderson