Patents Assigned to The United States Government as represented by the Department of Veterans Affairs
  • Methods of using an integrated surface stimulation device for wound therapy and infection control
    Patent number: 11478631
    Abstract: The present invention provides a thin and flexible device and method of use thereof for wound treatment and infection control. The integrated surface stimulation device may comprise wireless stimulation system in a disposable and/or reusable flexible device for widespread use in multiple therapeutic applications. The invention would be situated on the skin surface of a patient and would be activated so as to reduce the overall occurrence of infections and/or increase wound healing rates. As provided, the device will comprise an integrated power supply and pre-programmable stimulator/control system on a flexible polymeric substrate layer with areas of stimulating electrodes, applied using techniques such as those found in additive manufacturing processes. The device is especially valuable in treating biofilm-based infections.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: October 25, 2022
    Assignees: THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS, CASE WESTERN UNIVERSITY
    Inventors: Kath M. Bogie, Steven L. Garverick, Christian A. Zorman, Daniel S. Howe
  • SYRINGE PUMP CONTROLLER
    Publication number: 20220331517
    Abstract: Syringe pump controllers which memorialize the process of hydrodynamic isotonic saline delivery (HIFD) to reverse acute kidney injury are disclosed. In some embodiments, the syringe pump controllers are constructed to control syringe pump(s) to deliver a defined volume of saline at a prescribed perfusion rate while monitoring renal vein pressures during the infusion. In some embodiments, the syringe pump controllers have safety features designed to shut off the infusion if the renal vein pressure goes above set safety limits.
    Type: Application
    Filed: September 17, 2020
    Publication date: October 20, 2022
    Applicants: The Trustees of Indiana University, The United States Government as represented by the Department of Veterans Affairs
    Inventors: Mark S. Carlsen, Gregory S. Eakins, Robert M. Everly, Catherine L. McIntyre, Phillip J. Wyss, Robert L. Bacallao
  • Training manikin and systems and methods of using same
    Patent number: 11468794
    Abstract: A training manikin can have a front, a longitudinal axis, and a sagittal axis perpendicular to the longitudinal axis. The training manikin can comprise a head portion having an oral aperture. A simulated esophagus can be in communication with the oral aperture of the head portion. The simulated esophagus can be configured to receive a gastrointestinal tube. A simulated larynx can be positioned between the simulated esophagus and the front of the manikin relative to the sagittal axis. A reservoir can be configured to receive a liquid. A conduit in communication with the reservoir, can have an outlet end that is positioned proximate to the oral aperture of the head portion. A pump can be positioned between, and in communication with, the reservoir and the conduit and configured to begin pumping the liquid from the reservoir to the outlet end of the conduit upon a first condition.
    Type: Grant
    Filed: October 30, 2020
    Date of Patent: October 11, 2022
    Assignee: United States Government as Represented by the Department of Veterans Affairs
    Inventors: Jorge Lara-Gutierrez, Patrick Martino, Eric A. Heckenbach, Mary Ellen Elias, Dave Sullivan
  • Inhibitors of oxidized low-density lipoprotein receptor 1 and methods of use thereof
    Patent number: 11465972
    Abstract: Inhibitors of oxidized low-density lipoprotein receptor 1 (LOX-1), compositions comprising inhibitors of LOX-1, and methods of using thereof are described.
    Type: Grant
    Filed: December 19, 2019
    Date of Patent: October 11, 2022
    Assignees: THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS, BIOVENTURES, LLC
    Inventors: Jawahar L. Mehta, Magomed Khaidakov, Kottayil I. Varughese, Shraddha Thakkar, Yao Dai, Peter Crooks, Narsimha Reddy Penthala
  • Diagnosis of a disease condition using an automated diagnostic model
    Patent number: 11468558
    Abstract: A method of identifying an object of interest can comprise obtaining first samples of an intensity distribution of one or more object of interest, obtaining second samples of an intensity distribution of confounder objects, transforming the first and second samples into an appropriate first space, performing dimension reduction on the transformed first and second samples, whereby the dimension reduction of the transformed first and second samples generates an object detector, transforming one or more of the digital images into the first space, performing dimension reduction on the transformed digital images, whereby the dimension reduction of the transformed digital images generates one or more reduced images, classifying one or more pixels of the one or more reduced images based on a comparison with the object detector, and identifying one or more objects of interest from the classified pixels.
    Type: Grant
    Filed: October 11, 2018
    Date of Patent: October 11, 2022
    Assignees: UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS, UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Michael Abramoff, Gwenole Quellec
  • Flexible implantable tissue stimulator and methods of making and using same
    Patent number: 11458309
    Abstract: Provided are devices and methods for providing a flexible implantable tissue stimulator. A flexible implantable tissue stimulator can be use in a variety of medical/surgical procedures, and therapeutic interventions, such as musculoskeletal stimulation therapy. The flexible implantable tissue stimulator can be implanted via a minimally invasive procedure and comprises a biocompatible flexible construction that enables it to conform to a variety of implantation orientations and biological conditions. The flexible implantable tissue can provide programmable biphasic electrical stimulation to impaired tissue, such as a gluteal muscle.
    Type: Grant
    Filed: September 19, 2018
    Date of Patent: October 4, 2022
    Assignees: United States Government as Represented by the Department of Veterans Affairs, Case Western Reserve University
    Inventors: Christian Zorman, Douglas Shire, David Keicher, Katherine M. Bogie
  • Methods for DNA-dependent targeting of a cell permeant antibody
    Patent number: 11453725
    Abstract: The invention provides methods for selective targeting of live cells, which have undergone or are undergoing radiation or chemotherapy, at a site of interest with a cell-penetrating polypeptide. In one embodiment of the invention, the method comprises contacting the live cells with a cell-penetrating polypeptide comprising cell-penetrating determinants so that the cell-penetrating polypeptide binds extracellular DNA near or around the live cells so as to form a complex or association therewith such that the complex or associated polypeptide-DNA so bound bind the live cells and penetrates the live cells thereby selectively targeting live cells at a site of interest with a cell-penetrating polypeptide.
    Type: Grant
    Filed: August 19, 2019
    Date of Patent: September 27, 2022
    Assignee: THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Richard H. Weisbart, Robert N. Nishimura
  • Wound healing and tissue engineering
    Patent number: 11446331
    Abstract: The present invention is directed to wound healing scaffolds cografted with a population of stem cells, wherein the population of stem cells are ABCB5+ stem cells. The scaffolds are, for instance, collagen glycosaminoglycan scaffolds.
    Type: Grant
    Filed: May 9, 2014
    Date of Patent: September 20, 2022
    Assignees: The Brigham and Women's Hospital, Inc., Children's Medical Center Corporation, The United States Government as Represented by the Department of Veterans Affairs
    Inventors: Markus H. Frank, Natasha Y. Frank, Dennis P. Orgill, George F. Murphy
  • Compositions and methods for suppressing MSUT2
    Patent number: 11439658
    Abstract: Described herein are compositions and methods for treating Alzheimer's disease or dementia. The compositions include mammalian suppressor of taupathy 2 inhibitors (MSUT2). The MSUT2 inhibitors can be small interfering RNAs, guide RNAs, or small molecules. The methods include reducing accumulation of phosphorylated and aggregated human tau.
    Type: Grant
    Filed: April 12, 2019
    Date of Patent: September 13, 2022
    Assignees: United States Government As Represented By The Department Of Veterans Affairs, University of Washington
    Inventors: Brian Kraemer, Jeanna M. Wheeler, Pamela McMillan, Timothy J. Strovas, Jeremy Baker
  • COMBINATION CANCER THERAPY AGENTS AND METHODS
    Publication number: 20220280609
    Abstract: The present disclosure relates, in general, to methods for treating cancer comprising administering to a subject in need thereof an effective amount of CXCL9, CXCL10 or the combination, in combination with an immune checkpoint inhibitor. The CXCL9, CXCL10 or combination may be administered as a polypeptide, a polynucleotide or cells comprising a polynucleotide encoding CXCL9, CXCL10 or both. In one aspect, the treatment is amenable to patients with low or high mutational burden tumors.
    Type: Application
    Filed: July 17, 2020
    Publication date: September 8, 2022
    Applicants: The Regents of the University of California, United States Government Represented by the Department of Veterans Affairs
    Inventors: Steven M. DUBINETT, Bin LIU, Raymond LIM, Ramin SALEHI-RAD
  • METHODS FOR INHIBITING MUSCLE ATROPHY
    Publication number: 20220280535
    Abstract: The invention provides a method for (a) increasing skeletal muscle mass; (b) reducing skeletal muscle atrophy; (c) increasing muscular strength; (d) promoting muscle growth; (e) decreasing muscle wasting; or (f) increasing strength per unit of muscle mass in an animal identified or having been identified to be in need of one or more of (a)-(f), the method comprising administering to the animal an effective amount of a compound of formula: or a stereoisomer, solvate, or pharmaceutically acceptable salt thereof, thereby accomplishing one or more of (a)-(f).
    Type: Application
    Filed: May 17, 2021
    Publication date: September 8, 2022
    Applicants: UNIVERSITY OF IOWA RESEARCH FOUNDATION, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Christopher M. ADAMS, Steven D. KUNKEL, Michael WELSH
  • Prosthetic sock management tool
    Patent number: 11432948
    Abstract: A device and method for managing a plurality of groups of socks where the device includes a plurality of pouches attached to one another and a patient education and compliance tool. Each group has at least one sock. Socks of each of the groups have different characteristics from one another. The groups of socks are adapted for use between a limb of a patent and a socket of a prosthetic device. Each pouch is adapted for securing at least one sock from a group. The method includes sorting the plurality of groups of socks according to the characteristic, associating each pouch with a respective one of the groups, and securing each group of socks within an associated pouch.
    Type: Grant
    Filed: June 25, 2019
    Date of Patent: September 6, 2022
    Assignee: United States Government as represented by the Department of Veterans Affair
    Inventor: Billie Caris Savvas Slater
  • AMINO BENZOTHIAZOLE COMPOUNDS FOR TREATMENT OF ANTIBIOTIC RESISTANT BACTERIA
    Publication number: 20220267312
    Abstract: Provided herein are compounds of the formula: wherein the variables are as defined herein. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds may be used for the treatment of diseases or disorders, such as an infection of an antibiotic resistant bacteria.
    Type: Application
    Filed: January 19, 2022
    Publication date: August 25, 2022
    Applicants: Saint Louis University, United States Government as Represented by the Department of Veterans Affairs
    Inventors: John K. WALKER, Feng CAO, Terri BOEHM, Kinthada RAMAKUMAR
  • Bladder event detection for diagnosis of urinary incontinence or treatment of lower urinary tract dysfunction
    Patent number: 11419533
    Abstract: The present disclosure relates generally to using detected bladder events for the diagnosis of urinary incontinence or the treatment of lower urinary tract dysfunction. A system includes a sensing device comprising a pressure sensor to directly detect a pressure within a bladder. The sensing device is adapted to be located within the bladder. The system also includes a signal processing device to: receive a signal indicating the detected pressure within the bladder; detect a bladder event based the detected pressure within the signal; and characterize the bladder event as a bladder contraction event or a non-contraction event. The characterization of the bladder event can be used in the diagnosis of urinary incontinence or the treatment of lower urinary tract dysfunction.
    Type: Grant
    Filed: March 21, 2019
    Date of Patent: August 23, 2022
    Assignees: THE CLEVELAND CLINIC FOUNDATION, The United States Government as represented by the Department of Veterans Affairs, Case Western Reserve University
    Inventors: Margot S. Damaser, Swarup Bhunia, Robert Karam, Steve Majerus, Dennis Bourbeau, Hui Zhu
  • Wheelchair system with motion sensors and neural stimulation
    Patent number: 11419772
    Abstract: A system and method for improving stability of a wheelchair user includes a wheelchair having sensors measuring motion parameters to sense collisions and sharp turns which may unseat the user. Neuromuscular stimulating electrodes attached to extensor and flexor muscles of the user's trunk and under the command of a controller in communication with the sensors activate the muscles during turns and collisions to counteract the forces induced. A system and method for increasing manual propulsion efficiency includes sensors for sensing motion parameters indicating completion of a manual push of the wheelchair wheels and recovery from the push. Neuromuscular stimulating electrodes attached to extensor and flexor muscles of the user's trunk and under the command of a controller in communication with the sensors activate the muscles at the appropriate time in the cycle of push and recovery.
    Type: Grant
    Filed: August 7, 2018
    Date of Patent: August 23, 2022
    Assignee: United States Government as represented by the Department of Veterans Affairs
    Inventors: Ronald J. Triolo, Stephanie Bailey, Kevin M. Foglyano, Kiley Armstrong, Musa L. Audu
  • SPAK kinase inhibitors as neuroprotective agents
    Patent number: 11414379
    Abstract: The present disclosure is concerned with N-(5-chloro-4-((4-chlorophenyl)(cyano)methyl)-2-methylphenyl)benzamide compounds that are capable of inhibiting SPAK kinase function, methods of treating hypoxic brain injuries due to, for example, ischemic stroke. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: February 16, 2021
    Date of Patent: August 16, 2022
    Assignees: UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS, UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH OF HIGHER EDUCATION, XIAMAN UNIVERSITY, UNIVERSITY OF EXETER
    Inventors: Dandan Sun, Xianming Deng, Jinwei Zhang, Mohammad Iqbal Hossain Bhuiyan, Bradley J. Molyneaux
  • PAC1 RECEPTOR AGONISTS (MAXCAPS) AND USES THEREOF
    Publication number: 20220251162
    Abstract: In certain embodiments novel PAC1 receptor agonists are provided wherein the agonists comprise a targeting sequence that binds to the PAC1 receptor and said targeting sequence is attached to an amino acid sequence comprising a fragment of the maxadilan amino acid sequence, wherein the targeting sequence comprises a full-length 38 amino acid PACAP peptide or an N-terminus fragment thereof containing the amino acid sequence HSDGIF, wherein said targeting sequence optionally comprises an amino acid insertion between residues 11 and 12 of said PACAP peptide or fragment thereof; and the fragment of the maxadilan amino acid sequence comprises a fragment of the maxadilan sequence effective to activate PAC1 signaling.
    Type: Application
    Filed: October 25, 2021
    Publication date: August 11, 2022
    Applicants: The Regents of the University of California, The United States Government Represented by The Department Of Veterans Affairs
    Inventors: Joseph R. Pisegna, Patrizia M. Germano, John P. Vu
  • Compositions comprising 5-cholesten-3, 25-diol, 3-sulfate (25HC3S) or pharmaceutically acceptable salt thereof and at least one cyclic oligosaccharide
    Patent number: 11406646
    Abstract: Compositions comprising 5-cholesten-3,25-diol, 3-sulfate (25HC3S) or pharmaceutically acceptable salt thereof and at least one cyclic oligosaccharide, e.g., a cyclodextrin (CD), are provided. The compositions may be used to prevent and/or treat a variety of diseases and conditions, including organ failure (e.g. acute liver failure), high cholesterol/high lipids, and various inflammatory diseases and conditions.
    Type: Grant
    Filed: November 10, 2020
    Date of Patent: August 9, 2022
    Assignees: Virginia Commonwealth University, Durect Corporation, The United States Government as Represented by The Department of Veterans Affairs
    Inventors: Shunlin Ren, Leyuan Xu, Yanxia Ning, Jin Koung Kim, WeiQi Lin, Andrew R. Miksztal, Hongwei Wu, Min L. Lee
  • Dielectric sensing to characterize hemostatic dysfunction
    Patent number: 11408844
    Abstract: As one example, an apparatus includes a dielectric microsensor comprising a microfluidic chamber that includes a capacitive sensing structure, the microfluidic chamber including a fluid input port to receive a volume of a blood sample. A bioactive agent is disposed within the chamber to interact with the volume of the blood sample received in the microfluidic chamber. A transmitter provides an input radio frequency (RF) signal to an RF input of the dielectric microsensor. A receiver receives an output RF signal from an RF output of the dielectric microsensor. A computing device that computes dielectric permittivity values of the sample that vary over a time interval based on the output RF signal, the computing device to provide an assessment of hemostatic dysfunction and associated coagulopathy based on the dielectric permittivity values.
    Type: Grant
    Filed: April 1, 2020
    Date of Patent: August 9, 2022
    Assignees: CASE WESTERN RESERVE UNIVERSITY, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERAN AFFAIRS, UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Michael Suster, Pedram Mohseni, Anirban Sen Gupta, Matthew David Neal, Ujjal Didar Singh Sekhon, Sanjay Pitamber Ahuja, Sina Pourang, Debnath Maji
  • Computer pointing device
    Patent number: D967101
    Type: Grant
    Filed: July 31, 2020
    Date of Patent: October 18, 2022
    Assignees: United States Government as represented by the Department of Veterans Affairs, University of Pittsburgh—Of The Commonwealth System of Higher Education
    Inventors: Rory A. Cooper, Garrett G. Grindle, Zachary Kitzmiller Anzelone, Aaron Tyler Anderson