Abstract: As an example, a walker includes a first leg pair, a second leg pair and a cross beam connecting the first and second leg pairs in a parallel, spaced apart relationship. Each leg pair includes a U-shaped tube defining a front leg and a rear leg. A front strut is telescopically movable within the front leg and extends outwardly therefrom. A rear strut is telescopically movable within the rear leg and extends outwardly therefrom. A mechanical linear actuator includes a rotating element adapted to rotate relative to at least one of the front leg or the rear leg. The rotating element includes an interface with a track on the respective strut relative to which the rotating element rotates, whereby rotational motion of the rotating element translates to corresponding linear motion of the strut.

Abstract: Disclosed are compositions comprising an interferon-alpha binding protein and combined anti-retroviral therapy (cART). In some aspects, the interferon-alpha binding protein is B18R. In some aspects, the compositions further comprise a pharmaceutically acceptable carrier. Disclosed are methods of treating a subject with HIV associated neurogenerative disorder (HAND) comprising administering a therapeutically effective amount of B18R and cART. Disclosed are methods of reversing behavioral abnormalities in subjects having HAND comprising administering a therapeutically effective amount of B18R.

Abstract: Disclosed are morpholino oligonucleotides that can be used to silence expression of MGMT, pharmaceutical compositions that include said morpholino oligonucleotides, and methods of using said morpholino oligonucleotides in the treatment of cancer, particularly methods that involve the use of radiation to deliver said morpholino oligonucleotides.

Abstract: The present invention relates to optimized aptamers and methods of using these aptamers.

Abstract: Provided herein are methods and pharmaceutical compositions for treating cancer, in a patient in need thereof, said method comprising administering to said patient an effective amount of an EGFR inhibitor and a TNF inhibitor.

Abstract: The present invention provides synthetic methods and novel intermediates in the preparation of 3-aryl Endochin-like quinolone (ELQ) compounds.

Abstract: This disclosure provides compounds that inhibit RNA-binding proteins, such as Human antigen R protein (HuR). The compounds described herein have a high affinity for HuR multimers and inhibit the pathological processes that promote cancer and inflammation. The compounds are highly water-soluble and have good biodistribution for both systemic and central nervous system disease processes. The compounds provide a unique therapeutic option for disease processes related to neoplastic progression or acute or chronic inflammation.

Abstract: A trunk control system having a harness assembly and a flexion control assembly. The harness assembly has a backrest member and a harness secured to the backrest member. The backrest member is configured to be moveably coupled to a wheelchair. The backrest member is selectively moveable about and between a fully retracted position and a fully extended position. The harness cooperates with the backrest member to define a receiving space for receiving at least a portion of a torso of a wheelchair user. The flexion control assembly is coupled to the backrest member of the harness assembly. The flexion control assembly is configured to selectively permit or restrict movement of the backrest member about and between the fully retracted position and the fully extended position.

Abstract: The present invention is directed to wound healing scaffolds cografted with a population of stem cells, wherein the population of stem cells are ABCB5+ stem cells. The scaffolds are, for instance, collagen glycosaminoglycan scaffolds.

Abstract: A bench assembly can be for use in a bathtub for showering. The bench assembly can comprise a frame that is configured to sit within a bathtub. A bench can be coupled to the frame. A pivotable platform assembly can comprise a platform support structure pivotably coupled to the frame and a platform coupled to the platform support structure. The pivotable platform assembly can be configured to bias against an upper rim of the bathtub.

Abstract: The present disclosure is concerned with small molecule modulators of KLF15 signaling useful for treating various disorders such as, for example, kidney disease (e.g., chronic kidney disease), heart disease, obesity, or a neurodegenerative disorder (e.g., amyotrophic lateral sclerosis (ALS), Alzheimer's disease, Parkinson's disease, spinal muscular atrophy, traumatic brain injury, vascular dementia, Huntington's disease, mental retardation, and attention deficit and hyperactivity disorder (ADHD)). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: The present invention provides methods for cancers associated with a TERT promoter mutation in a subject. In some embodiments, the methods comprise administering to the subject a therapeutically effective amount of an agent that specifically reduces or inhibits GA binding protein transcription factor beta subunit 1 long isoform (GABPBIL) expression or function.

Abstract: The methods and systems provided can automatically determine an Arteriolar-to-Venular diameter Ratio, AVR, in blood vessels, such as retinal blood vessels and other blood vessels in vertebrates. The AVR is an important predictor of increases in the risk for stroke, cerebral atrophy, cognitive decline, and myocardial infarct.

Abstract: A method for forming a prosthesis comprising a bone-like portion and a cartilage-like portion can comprise additively manufacturing a first positive mold in accordance with a portion of a first three-dimensional model of a portion of a bone. A first negative mold can be formed from the first positive mold. The bone-like portion can be created within the first negative mold. A second positive mold of the bone and a cartilage can be additively manufactured from a second three-dimensional model. A portion of the second three-dimensional model can correspond to a portion of the first three-dimensional model. A second negative mold can be formed from the second positive mold. The bone-like portion can be positioned in the second negative mold so that the second negative mold and the bone-like portion can define a cartilage space that can be filled with a material to form the cartilage-like portion of the prosthesis.

Abstract: The present disclosure is concerned with thioquinolinone compounds for the treatment of disorders associated with heme oxygenase-1 (HO-1) signaling dysfunction such as, for example, kidney diseases (e.g., chronic kidney disease, acute kidney injury). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: Methods for disinfecting a surface are provided which include contacting a surface with a solution comprising Fe(VI)O42?, thereby disinfecting the surfaces. In some cases, the surface to be contacted with the solution is in a space suitable for human occupancy and the surface is arranged in the ambient of the space. In addition, solutions comprising Fe(VI)O42? are provided. The solutions may additionally include a hypohalite salt and a surfactant.

Abstract: The present invention pertains to a strategy of selectively targeting oncolytic virotherapy, using either naturally occurring or genetically modified viruses by packaging them in mesenchymal stem cells (MSCs). The present invention concerns MSCs, compositions comprising the MSCs, and methods of using the MSCs for treatment of cancer and for lysing or inducing apoptosis of cancer cells in vitro or in vivo.

Abstract: A system for industrial application package management includes a computing device having a processor and a memory having executable programs and applications stored thereon, including plurality of industrial application programs miming an engineering project involving multiple different disciplines, and a package manager client. The package manager client communicates with a remote repository server that hosts application packages, and sends requests for packages and receives package deliveries. The package manager client unbundles package metainformation relevant to a domain specific application and according to an industrial package information schema. A dependency tracking module identifies dependencies of a current package to other packages and generates a dependency tree that includes the name and version of each dependent package.

Abstract: The present invention provides methods and materials useful delivering liquids, including liquids comprising nucleic acid molecules into cells. In particular, the present invention provides methods for delivering saline solution, exogenous compositions, and isolated vectors to kidney cells, using the renal vein as a guide and under hydrodynamic pressure. The delivery methods and materials herein are useful to research, prognose, ameliorate symptoms of kidney injury, and treat kidney pathologies.

Abstract: Aspects of the cutaneous stimulation devices include a cutaneous stimulation module and a cutaneous association element configured to stably associate the module with a skin location. The cutaneous stimulation module may be an active or passive module. Also provided are methods of using the devices, e.g., in rehabilitation and/or pain mitigation applications.