Patents Assigned to The United States of America, as represent by the Secretary, Department of Health and Human Services
  • Engineered antibody constant domain molecules
    Patent number: 9527903
    Abstract: Described herein are engineered antibody constant domain molecules, such as CH2 or CH3 domain molecules, comprising at least one mutation, or comprising at least one complementarity determining region (CDR), or a functional fragment thereof, engrafted in a loop region of the CH2 domain. The CH2 domain molecules described herein are small, stable, soluble, exhibit little to no toxicity and are capable of binding antigen.
    Type: Grant
    Filed: October 1, 2013
    Date of Patent: December 27, 2016
    Assignee: The United States of America, as represent by the Secretary, Department of Health and Human Services
    Inventor: Dimiter S. Dimitrov