Patents Assigned to The United States of America as represented by the Department of Health and Human Services (DHHS)
  • Phosphonyl ester conjugates as prodrugs
    Patent number: 8063209
    Abstract: Cidofovir or foscarnet based compounds having an amino acid or dipeptide esters are provided as prodrugs.
    Type: Grant
    Filed: March 16, 2009
    Date of Patent: November 22, 2011
    Assignees: TSRL, Inc., National Institute of Health (NIH), The United States of America as represented by the Department of Health and Human Services (DHHS), The United States of America as represented by the NIH Division of Extramural Inventions and Technology Resources (DEITR)
    Inventors: John Hilfinger, Charles E. McKenna, Boris A. Kashemirov, Chi Pham, Kanokkarn Saejueng, Larryn Peterson
  • Recognition of oligosaccharide molecular targets by polycationic small molecule inhibitors and treatment of immunological disorders and infectious diseases
    Patent number: 7662999
    Abstract: Small molecule polycationic agents are used to modulate or interrupt biological processes by binding to oligosaccharide-based biomolecules. Compounds that inhibit nitric oxide, TNF? or other immunomodulators are provided and are useful for treating immunological disease and disease of an infectious disorder.
    Type: Grant
    Filed: March 30, 2007
    Date of Patent: February 16, 2010
    Assignees: National Institutes of Health (NIH), The United States of America as represented by the Department of Health and Human Services (DHHS)
    Inventors: Mark R. Burns, Sunil A. David