Patents Assigned to The United States of America as represented by the Department of Health and Human Services, National Institutes of Health
  • Capsid-free AAV vectors, compositions, and methods for vector production and gene delivery
    Patent number: 9598703
    Abstract: An isolated linear nucleic acid molecule comprising in this order: a first adeno-associated virus (AAV) inverted terminal repeat (ITR), a nucleotide sequence of interest and a second AAV ITR, wherein said nucleic acid molecule is devoid of AAV capsid protein coding sequences. The said nucleic acid molecule can be applied to a host at repetition without eliciting an immune response. Methods for producing and purifying this nucleic acid molecule, and use of the same for therapeutic purposes are also provided.
    Type: Grant
    Filed: March 12, 2012
    Date of Patent: March 21, 2017
    Assignees: ASSOCIATION INSTITUT DE MYOLOGIE; UNIVERSITÉ PIERRE ET MARIE CURIE (PARIS 6); CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; INSTITUT NATIONAL DE LA SANTÉ DE LAD RECHERCHE MÉDICALE, THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTES OF HEALTH
    Inventors: Luis Garcia, Cyriaque Beley, Thomas Voit, Robert Michael Kotin, Lina Li
  • Method of diagnosing poor survival prognosis colon cancer using miR-103-2
    Patent number: 8338104
    Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.
    Type: Grant
    Filed: November 15, 2011
    Date of Patent: December 25, 2012
    Assignees: The Ohio State University Research Foundation, The United States of America, as represented by the Department of Health and Human Services, National Institute of Health, Office of Technology Transfer
    Inventors: Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter
  • Method of diagnosing poor survival prognosis colon cancer using microRNA-21
    Patent number: 8084199
    Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. The invention also provides methods of identifying inhibitors of tumorigenesis.
    Type: Grant
    Filed: July 12, 2007
    Date of Patent: December 27, 2011
    Assignees: The Ohio State University Research Foundation, The United States of America as represented by the Department of Health and Human Services, National Institutes of Health, Office of Technology Transfer
    Inventors: Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter
  • Target-specific, cytotoxic, recombinant pseudomonas exotoxin
    Patent number: 5705163
    Abstract: A target-specific, cytotoxic, recombinant Pseudomonas exotoxin is described. Such toxins are made by inserting specific recognition molecules at specific cloning sites in at least domain III near the carboxyl terminus of the PE molecule. Various modifications of the carboxyl terminus of the PE molecule to increase cytotoxicity are set forth. Multifunctional, recombinant, cytotoxic fusion proteins containing at least two different recognition molecules are provided for killing cells expressing receptors to which the recognition molecules bind with specificity. Methods for producing novel recombinant PE molecules with specific properties are described.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: January 6, 1998
    Assignee: The United States of America as represented by the Department of Health and Human Services, National Institutes of Health
    Inventors: Ira Pastan, Vijay K. Chaudhary, David Fitzgerald