Patents Assigned to The United States of America as represented by the Department of Veterans Affairs
  • Patent number: 12011282
    Abstract: An instrumented trail-making task (iTMT) platform includes a wearable sensor and interactive interface technology configured to identify cognitive-cognitive impairment in individuals such as older adults. The iTMT platform may be programmed with neuropsychological tests for assessing individuals. The iTMT may provide information on visual search, scanning, speed of processing, mental flexibility, and/or executive functions as well as physical biomarkers of motor performance including slowness, weakness, exclusion, and/or motor planning error. Results of tests administered by the iTMT system may be reported to a patient or caregiver and used in identifying cogni-tive-motor impairment among individuals suffering from cognitive impairment, dementia, and/or those with frailty status, and/or cognitive frailty, and/or high risk of falling, and/or high likelihood of decline in cognitive-motor over time.
    Type: Grant
    Filed: September 18, 2017
    Date of Patent: June 18, 2024
    Assignees: Baylor College of Medicine, Arizona Board of Regents on behalf of Arizona State University, The United States of America as represented by the Department of Veterans Affairs
    Inventors: Bijan Najafi, Javad Razjouyan, He Zhou, Mark Kunik
  • Publication number: 20240166703
    Abstract: The present disclosure provides a novel IKK2 inhibitor that does not target the kinase domain of IKK2 molecule. The novel IKK2 inhibitor is a cell penetrating NEMOActPep comprising a small segment (residues 384-389) of human NEMO to mediate interaction with and promote activation loop phosphorylation of IKK2. The NEMOActPep is derived from the second interaction interface of NEMO:IKK2 that is dependent upon NEMO binding to linear polyubiquitin. Methods of use the novel IKK2 inhibitor, and composition thereof, for preventing and/or treating inflammation in various diseases involving IKK-NF-?B signaling pathways are also provided.
    Type: Application
    Filed: March 30, 2022
    Publication date: May 23, 2024
    Applicants: The Regents of the University of California, SAN DIEGO STATE UNIVERSITY (SDSU) FOUNDATION, THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Gourisankar GHOSH, Sushil MAHATA, Tom HUXFORD
  • Patent number: 11911392
    Abstract: Compounds that inhibit p38? MAPK protein, and methods of using the same, are provided for treating or preventing diseases such as cancer or inflammatory diseases.
    Type: Grant
    Filed: May 9, 2022
    Date of Patent: February 27, 2024
    Assignees: UNIVERSITY OF MARYLAND, BALTIMORE, THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Paul S. Shapiro, Alexander D. Mackerell, Jr., Jeffrey D. Hasday
  • Patent number: 11911393
    Abstract: Compounds that inhibit p38? MAPK protein, and methods of using the same, are provided for treating or preventing diseases such as cancer or inflammatory diseases.
    Type: Grant
    Filed: February 15, 2023
    Date of Patent: February 27, 2024
    Assignees: University of Maryland, Baltimore, The United States of America as represented by The Department of Veterans Affairs
    Inventors: Paul S. Shapiro, Alexander D. Mackerell, Jr., Jeffrey D. Hasday
  • Patent number: 11793794
    Abstract: The present invention provides compositions and methods for treating diseases or disorders using a therapeutically effective amount of a rapid-acting antidepressant (RAAD) and a therapeutically effective amount of a mTOR inhibitor and/or immunosuppressant. In certain embodiments, the RAAD and the mTOR inhibitor and/or immunosuppressant are part of a single pharmaceutical composition.
    Type: Grant
    Filed: October 25, 2022
    Date of Patent: October 24, 2023
    Assignees: YALE UNIVERSITY, THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Chadi Abdallah, John Krystal, Ronald Duman, Gerard Sanacora
  • Publication number: 20230330116
    Abstract: Various aspects and embodiments disclosed herein relate generally to the modelling, treatment, reducing resistence to the treatment, prevention, and diagnosis of diseases/symptoms induced by multiple myeloma. Embodiments include methods of treating a bone related disease, comprising the steps of: administering to a subject at least one therapeutically effective dose of a compound disclosed herein.
    Type: Application
    Filed: March 30, 2023
    Publication date: October 19, 2023
    Applicants: Indiana University Research and Technology Corporation, University of Rochester, The United States of America As Represented by the Department of Veterans Affairs Office of General
    Inventors: Teresita M. Bellido, G. David Roodman, Jesus Delgado-Calle, Robert K. Boeckman, Frank H. Ebetino
  • Patent number: 11760987
    Abstract: In alternative embodiments, provided are compositions, including products of manufacture and kits, and methods, for treating a heart failure in a subject in need thereof comprising administering to the subject an isolated or recombinant nucleic acid, an isolated or recombinant or chimeric polypeptide, or an engineered cell, as provided herein, thereby treating the subject. In alternative embodiments, the administration reduces left ventricular (LV) hypertrophy, increases LV peak pressure development, reduced cAMP production and/or improves LV peak pressure decay in a pressure-overload in the subject. In alternative embodiments, provided are compositions and methods for: treating, ameliorating, or slowing the progress of, or protecting (preventing) an individual or a patient against heart failure; or, reducing LV hypertrophy, increasing LV peak pressure development, and/or improving LV peak pressure decay in a pressure-overload in an individual in need thereof.
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: September 19, 2023
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: H. Kirk Hammond, Mei Hua Gao, Ngai Chin Lai
  • Patent number: 11744864
    Abstract: The present invention provides compositions comprising phosphatidylcholine derived compounds carrying an omega-3 fatty acid for use in prophylaxis or therapy, particularly when administered systemically. This invention further relates to a modified krill oil composition enriched in LPC-DHA and LPC-EPA, methods of making and methods of using to treat neurological and ocular disorders.
    Type: Grant
    Filed: March 31, 2021
    Date of Patent: September 5, 2023
    Assignee: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Finn Myhren, Petter-Arnt Hals, Nils Hoem, Andreas Berg Storsve, Papasani V. Subbaiah, Poorna Yalagala, Sugasini Dhavamani, Leon Tai
  • Patent number: 11634381
    Abstract: Provide herein are compounds with a general chemical structure of: Substituents R1 and R2 independently are H, Cl, F, Br, CH3, CF3, SH, —N(C1-3alkyl)2, —NHC(O)C1-3alkyl, or —NHC(O)C5-7cycloalkyl, substituent R3 is H or C1-3 alkyl and R4 is a bridged cycloalkene such as a bridged cyclohexene or a bridge-substituted cyclohexene. The compounds are therapeutics to treat a cancer, such as breast cancer, or metastatic cancers, to inhibit RUNX2 activity, such as protein expression, in a cancer cell and to increase survival of a subject with breast cancer.
    Type: Grant
    Filed: May 3, 2019
    Date of Patent: April 25, 2023
    Assignees: University of Maryland, Baltimore, The United States of America as Represented by the Department of Veterans Affairs
    Inventors: Antonino Passaniti, Alexander D. MacKerell, Jr.
  • Patent number: 11550014
    Abstract: A method for phase-contrast magnetic resonance imaging (PC-MRI) acquires undersampled PC-MRI data using a magnetic resonance imaging scanner and reconstructs MRI images from the undersampled PC-MRI data by reconstructing a first flow-encoded image using a first convolutional neural network, reconstructing a complex difference image using a second convolutional neural network, combining the complex difference image and the first flow-encoded image to obtain a second flow-encoded image, and generating a velocity encoded image from the first flow-encoded image and second flow-encoded image using phase difference processing.
    Type: Grant
    Filed: February 16, 2022
    Date of Patent: January 10, 2023
    Assignees: The Board of Trustees of the Leland Stanford Junior University, The United States of America as represented by The Department Of Veterans Affairs
    Inventors: Daniel B. Ennis, Matthew J. Middione, Julio A. Oscanoa Aida, Shreyas S. Vasanawala
  • Publication number: 20220332692
    Abstract: Tocol derivative compounds, compositions comprising these tocol derivatives and methods of using the tocol derivatives are provided herein. Specifically the tocol derivatives have a partially unsaturated hydrocarbon tail and are thus distinct from the tocopherols. The hydrocarbon tails do not have a trans carbon-carbon double bond in the second isoprene unit of the hydrocarbon tail and are distinct from the tocotrienols. The compounds are expected to allow improved interaction with the a-tocopherol transfer protein receptor than the tocotrienols and better bioactivity than the tocopherols.
    Type: Application
    Filed: July 5, 2022
    Publication date: October 20, 2022
    Applicants: BIOVENTURES, LLC, THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Cesar Compadre, Philip J. Breen, Martin Hauer-Jensen, Kottayil Varughese, K. Sree Kumar
  • Patent number: 11446506
    Abstract: An example system and method associated with identifying and treating a source of a heart rhythm disorder are disclosed. In accordance therewith, a spatial element associated with a region of the heart is selected. Progressive rotational activations or progressive focal activations are determined in relation to the selected spatial element over a period of time. The selecting and determining are repeated over multiple periods of time. A source parameter of rotation activations or focal activations is determined, wherein the source parameter indicates consistency of successive rotational activations or focal activations in relation to a portion of the region of the heart. The determining of a source parameter is repeated for multiple regions of the heart. Thereafter, representation of the source parameter is displayed for each of the multiple regions of the heart to identify a shape representing the source of the heart rhythm disorder.
    Type: Grant
    Filed: September 5, 2019
    Date of Patent: September 20, 2022
    Assignees: The Regents of the University of California, The United States of America as Represented by the Department of Veterans Affairs, Topera, Inc.
    Inventors: Sanjiv M. Narayan, Carey Robert Briggs, Ruchir Sehra
  • Patent number: 11433153
    Abstract: The invention provides method for organizing the disinfection of one or more items contaminated with biological agent(s) comprising (a) attaching a radio-frequency ID (RFID) tag to an item(s) to be disinfected; exposing the item(s) of (a) to a disinfecting means for a period sufficient to disinfect the item; and (c) obtaining a signal from the tagged item when disinfection is complete thereby organizing the disinfection of one or more items.
    Type: Grant
    Filed: September 25, 2020
    Date of Patent: September 6, 2022
    Assignee: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventor: Chetan Jinedatha
  • Publication number: 20220273845
    Abstract: A method for regeneration or repair of an infarcted myocardium including an infarcted region in an animal comprising injecting into the animal a composition including one or more gold nanostructures is disclosed.
    Type: Application
    Filed: May 9, 2022
    Publication date: September 1, 2022
    Applicants: Arizona Board of Regents on Behalf of Arizona State University, The United States of America as Represented by The Department of Veterans Affairs
    Inventors: Mehdi Nikkhah, Ali Navaei, Raymond Migrino
  • Patent number: 11364321
    Abstract: A scaffold-free microtissue is disclosed that includes one or more gold nanostructures linked to a functional moiety, wherein the functional moiety is one or more vasculogenic peptides, one or more anti-inflammatory peptides, one or more antiapoptotic peptides, one or more antinecrotic peptides, one or more antioxidant peptides, one or more oligonucleotides, one or more lipid particles, one or more phospholipid particles, one or more liposomes, one or more nanoliposomes, one or more microRNAs, or one or more siRNAs. The scaffold-free microtissue further includes a plurality of cardiac myocytes or cardiac myoblasts, which are conjugated to the one or more gold nanostructures, wherein the plurality of cardiac myocytes or cardiac myoblasts are arranged in a cluster.
    Type: Grant
    Filed: October 11, 2018
    Date of Patent: June 21, 2022
    Assignees: Arizona Board of Regents on Behalf of Arizona State University, The United States of America as Represented by The Department of Veterans Affairs
    Inventors: Mehdi Nikkhah, Ali Navaei, Raymond Migrino
  • Patent number: 11357781
    Abstract: Compounds that inhibit p38? MAPK protein, and methods of using the same, are provided for treating or preventing diseases such as cancer or inflammatory diseases.
    Type: Grant
    Filed: April 15, 2021
    Date of Patent: June 14, 2022
    Assignees: University of Maryland, Baltimore, The United States of America as represented by The Department of Veterans Affairs
    Inventors: Paul S. Shapiro, Alexander D. MacKerell, Jr., Jeffrey D. Hasday
  • Patent number: 11337622
    Abstract: A method is described for providing deficit-adjusted adaptive assistance during movement phases of an impaired ankle. The method includes determining, on the processor, a value for a deficit parameter for each movement phase of a compound ankle function based on a difference between a parameter trace for a normal subject and the parameter trace for an impaired subject. The method further includes determining, on the processor, an adaptive magnitude for the robot-applied torque based on the value for the deficit parameter. The method further includes applying, to the robot joint, the adaptive magnitude for the robot-applied torque in only a first plane for the current movement phase, based on an adaptive timing. An apparatus is also described for providing deficit-adjusted adaptive assistance during movement phases of the impaired ankle.
    Type: Grant
    Filed: June 20, 2016
    Date of Patent: May 24, 2022
    Assignees: UNIVERSITY OF MARYLAND, BALTIMORE, The United States of America as represented by the Department of Veterans Affairs
    Inventors: Richard F. Macko, Anindo Roy
  • Publication number: 20220118024
    Abstract: Various aspects and embodiments of the present invention are directed to methods of treating a subject having an ocular condition, methods of isolating ocular stem cells, methods of selecting and/or producing ocular grafts for transplantation, and methods of promoting ocular cell regeneration as well as to grafts and preparations containing isolated ocular stem cells characterized by the expression of ABCB5 on their cell surface.
    Type: Application
    Filed: September 27, 2021
    Publication date: April 21, 2022
    Applicants: The United States of America as represented by the Department of Veterans Affairs, Schepens Eye Research Institute, Children's Medical Center Corporation
    Inventors: Markus H. Frank, Natasha Y. Frank, Bruce Ksander, Paraskevi Evi Kolovou
  • Patent number: 11304601
    Abstract: The invention provides methods and kits for detecting, screening, quantifying or localizing the etiology for reduced or impaired cranial nerve function or conduction or associated cranial nucleus or supranuclear input, useful for detecting, diagnosing or screening for increased intracranial pressure, or useful for detecting, diagnosing, monitoring progression of or screening for a disease or condition featuring increased intracranial pressure by tracking eye movement of the subject. The methods may be performed by a) analyzing eye movement of the subject; b) comparing eye movement of the subject to eye movement of a control or the subject's own baseline eye movement; and c) identifying the subject as having eye movement significantly different from the control or the subject's own baseline eye movement.
    Type: Grant
    Filed: January 29, 2019
    Date of Patent: April 19, 2022
    Assignees: New York University, The United States of America as Represented by the Department of Veterans Affairs
    Inventors: Uzma Samadani, Shani Offen, Marisa Carrasco-Queijeiro, David Heeger
  • Patent number: 11286251
    Abstract: The present invention provides certain compounds, or salts or solvates thereof, which can be used as matrix metalloproteinase-targeted inhibitors or imaging agents.
    Type: Grant
    Filed: April 7, 2017
    Date of Patent: March 29, 2022
    Assignees: YALE UNIVERSITY, THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Mehran Sadeghi, Yunpeng Ye, Hye-Yeong Kim, Henry(Yiyun) Huang, Jakub Toczek