Patents Assigned to The United States of America, as represented by the Department of Veterens Affairs
  • Method of characterizing and manipulating adipose stem cell depots to a metabolically healthy state
    Patent number: 10196612
    Abstract: A method of reprogramming omental adipose cells to a subcutaneous-like lineage is presented herein. The method comprises exposing omental adipose cells to a small molecule such as Basic Fibroblast Growth Factor (bFGF); TRC105; long noncoding RNAs (lncRNAs) MALAT1, GAS5, linc-VLDLR; transcription factors Sox15, Oct4, KLF4, Nanog, Sal4, BMI1; or combinations thereof.
    Type: Grant
    Filed: July 11, 2017
    Date of Patent: February 5, 2019
    Assignees: University of South Florida, The United States of America as Represented by the Department of Veterens Affairs
    Inventors: Niketa A. Patel, Ghattas El Bassit
  • High molecular weight derivatives of vitamin K-dependent polypeptides
    Patent number: 8632771
    Abstract: Modifications of vitamin K-dependent polypeptides that lead to enhanced protein function on a weight or molar basis and/or increase of protein lifetime in the circulation are described. Both objectives are important for using vitamin K-dependent polypeptides for pro- and anti-coagulation therapies, as well as for other uses in the circulation.
    Type: Grant
    Filed: April 4, 2007
    Date of Patent: January 21, 2014
    Assignees: Regents of the University of Minnesota, The United States of America as represented by Department of Veterens Affairs
    Inventors: Gary L. Nelsestuen, Ronald Bach, Matthew Stone, Stephen Barrett Harvey
  • Reversible hydrogel systems and methods therefor
    Patent number: 8192485
    Abstract: The present invention relates to reversible hydrogel systems for medical applications. Particularly, the hydrogel of the present invention is made up of copolymers that can be a hydrogel when in an oxidized state and can be a solution when in a reduced state. A solution of the copolymer can be oxidized to form a hydrogel; and the hydrogel can be reduced to form a solution of the copolymer. The solution can be dehydrated to produce the dry copolymer for storage. Furthermore, the present invention also relates to methods of making and using the reversible hydrogel systems.
    Type: Grant
    Filed: November 13, 2003
    Date of Patent: June 5, 2012
    Assignees: The United States of America, as represented by the Department of Veterens Affairs, The Washington University in St. Louis
    Inventor: Nathan Ravi