Patents Assigned to The United States of America as represented by the Department Secretary of Health and Human Services
  • Quantitative real-time assay for Noroviruses and Enteroviruses with built in quality control standard
    Patent number: 8574844
    Abstract: A method is provided for reverse transcription-polymerase chain reaction (RT-PCR) accomplished by: a) amplifying a reverse transcribed cDNA in a mixture containing Norovirus Genogroup I and Norovirus Genogroup II primers and probes, in which the Norovirus primers and probes can distinguish between Genogroup I and Genogroup II viruses; b) quantifying virus; and c) normalizing data based on a universal internal RNA control. Optionally, the method may also include primers and probes for Enteroviruses. The present invention also provides a reaction mixture containing Norovirus Genogroup I and Norovirus Genogroup II primers and probes, in which the Norovirus primers and probes can distinguish between Genogroup I and Genogroup II viruses and universal internal RNA control primers and probes.
    Type: Grant
    Filed: October 1, 2007
    Date of Patent: November 5, 2013
    Assignee: The United States of America as represented by the Department Secretary of Health and Human Services
    Inventors: William Burkhardt, III, Michael C. L. Vickery, Jessica Nordstrom
  • Production and use of human nm23 protein and antibodies therefor
    Patent number: 6329198
    Abstract: Human nm23 DNA and protein is disclosed as well as antibodies which recognize human nm23 protein. The DNA and antibodies may be used to detect nm23 in human tumors to predict the malignancy potential of such tumors.
    Type: Grant
    Filed: June 18, 1999
    Date of Patent: December 11, 2001
    Assignee: The United States of America as represented by the Department of Secretary Health & Human Services
    Inventors: Charles Richter King, Patricia Schriver Steeg, Lance A. Liotta