Patents Assigned to The United States of America,as represented by the Secretary, Department of Health and Human Servic
  • Publication number: 20240050554
    Abstract: Vaccines that elicit broadly protective anti-influenza antibodies. The vaccines comprise nanoparticles that display HA trimers from Group 2 influenza virus on their surface. The nanoparticles are fusion proteins comprising a monomeric subunit (e.g., ferritin) joined to stabilized stem regions of Group 2 influenza virus HA proteins. The fusion proteins self-assemble to form the HA-displaying nanoparticles. Also provided are fusion proteins, and nucleic acid molecules encoding such proteins, and assays using nanoparticles of the invention to detect anti-influenza antibodies.
    Type: Application
    Filed: October 20, 2023
    Publication date: February 15, 2024
    Applicant: The United States of America, as represented by the Secretary, department of Health and Human Servic
    Inventors: Jeffrey C. Boyington, Barney S. Graham, John R. Mascola, Hadi M. Yassine, Kizzmekia S. Corbett, Syed M. Moin, Lingshu Wang, Masaru Kanekiyo
  • Publication number: 20240024458
    Abstract: Metapneumovirus (MPV) F proteins stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the MPV F proteins and/or nucleic acid molecules can be used to generate an immune response to MPV in a subject. In additional embodiments, the therapeutically effective amount of the MPV F ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing MPV infection.
    Type: Application
    Filed: September 6, 2023
    Publication date: January 25, 2024
    Applicants: The United States of America, as represented by the Secretary, Department of Health and Human Servic, Institute For Research in Biomedicine
    Inventors: Peter Kwong, Michael Gordon Joyce, Baoshan Zhang, Yongping Yang, Peter Collins, Ursula Buchholz, Davide Corti, Antonio Lanzavecchia, Guillaume Stewart-Jones
  • Publication number: 20230381293
    Abstract: Recombinant Norovirus Virus-Like Particles (VLPs) formed from recombinant Norovirus VP1 proteins, and methods of their use and production are disclosed. In several embodiments, the Recombinant Norovirus VLPs can be used to generate an immune response to Norovirus VP1 protein in a subject. In additional embodiments, an effective amount of the recombinant Norovirus VLPs can be administered to a subject in a method of inhibiting a Norovirus infection.
    Type: Application
    Filed: October 14, 2021
    Publication date: November 30, 2023
    Applicants: The United States of America, as represented by the Secretary, Department of Health and Human Servic, The University of North Carolina at Chapel Hill, Board of Regents, the University of Texas System
    Inventors: Peter Kwong, Raffaello Verardi, Yaroslav Tsybovsky, Jason Gorman, Gwo-Yu Chuang, Li Ou, Lisa Lindesmith, Ralph Baric, George Georgiou, Inga Rimkute, Mario Roederer
  • Publication number: 20230355677
    Abstract: Disclosed are nucleic acids and polypeptides which provide the co-expression of interleukin (IL)-21 and IL-15 by a host cell, each interleukin being bound to the cell membrane by a cell membrane anchor moiety. Also disclosed are related recombinant expression vectors, host cells, populations of cells, pharmaceutical compositions, and methods of treating or preventing cancer.
    Type: Application
    Filed: May 2, 2023
    Publication date: November 9, 2023
    Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Servic
    Inventors: Christian S. Hinrichs, Benjamin Y. Jin
  • Publication number: 20230355126
    Abstract: Multidimensional MRI-based methods permit identification and categorization of brain specimens to identify sub-voxel tissue components that are specific to traumatic axon injury or other lesions. Lower dimensional MR spectral data is acquired and processed to provide multidimensional MR data of higher dimensions. One or more spectral ranges are selected that define signatures for brain injury and evaluation of the multidimensional MR data in these ranges is used to locate voxels associated with brain injury. For example, partial one dimensional data sets such as T1, T2, and mean diffusion coefficient (MD) data sets can be combined to provide two dimensional data sets such as T1-T2, MD-T2, and MD-T1 data sets. Using the spectral signatures, a specimen image can be produced showing areas of lesser or greater injury.
    Type: Application
    Filed: July 14, 2021
    Publication date: November 9, 2023
    Applicants: The Henry M. Jackson Foundation for the Advancement for the Advancement of Military Medicine, Inc., The United States of America, as represented by the Secretary, Department of Health and Human Servic
    Inventors: Dan Haim Benjamini, Peter J. Basser, Diego Iacono
  • Publication number: 20230340066
    Abstract: Disclosed is a T cell receptor (TCR) having antigenic specificity for an HLA-A2-restricted epitope of human papillomavirus (HPV) 16 E6, E629-38. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells are also provided. Antibodies, or an antigen binding portion thereof, and pharmaceutical compositions relating to the TCRs of the invention are also provided. Also disclosed are methods of detecting the presence of a condition in a mammal and methods of treating or preventing a condition in a mammal, wherein the condition is cancer, HPV 16 infection, or HPV-positive premalignancy.
    Type: Application
    Filed: May 25, 2023
    Publication date: October 26, 2023
    Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Servic
    Inventors: Christian S. Hinrichs, Steven A. Rosenberg
  • Publication number: 20230323425
    Abstract: Methods of sample preparation for detection of nucleic acids (such as viral nucleic acids, for example, viral RNA) are provided. In some examples, the methods include contacting a sample with a solution including a buffer containing about 0-0.5 mM EDTA and a chelating resin and incubating the resulting mixture at a temperature of at least about 55° C.
    Type: Application
    Filed: August 12, 2021
    Publication date: October 12, 2023
    Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Servic
    Inventors: Bin Guan, Robert B. Hufnagel
  • Publication number: 20230295242
    Abstract: The invention features modified alphavirus or flavivirus virus-like particles (VLPs). The invention provides methods, compositions, and kits featuring the modified VLPs. The invention also features methods for enhancing production of modified VLPs for use in the prevention or treatment of alphavirus and flavivirus-mediated diseases. The invention also provides methods for delivering agents to a cell using the modified VLPs.
    Type: Application
    Filed: June 7, 2023
    Publication date: September 21, 2023
    Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Servic
    Inventors: Gary J. Nabel, Srinivas Rao, Wataru Akahata
  • Publication number: 20230293530
    Abstract: An agent which increases pyrimidine to purine ration in a cell without decreasing pyrimidine synthesis for use in a method of treating a solid tumor in a subject in need thereof, optionally in combination with an immune-modulating drug.
    Type: Application
    Filed: June 24, 2020
    Publication date: September 21, 2023
    Applicants: Yeda Research and Development Co. Ltd., The United States of America, as Represented by the Secretary, Department of Health and Human Servic
    Inventors: Ayelet EREZ, Rom KESHET, Lital ADLER, Eytan RUPPIN, Lee Joo SANG
  • Publication number: 20230290467
    Abstract: The invention features methods that are useful for treatment of a patient at increased risk for infection and for selecting a patient for treatment for an infection. In various embodiments, the infection is coronavirus disease 2019 (COVID-19), sepsis, or other respiratory infections.
    Type: Application
    Filed: March 14, 2023
    Publication date: September 14, 2023
    Applicants: The Broad Institute, Inc., The United States of America, as represented by the Secretary, Department of Health and Human Servic, Yale University, The General Hospital Corporation
    Inventors: Pradeep NATARAJAN, Giulio GENOVESE, Seyedeh Maryam ZEKAVAT, Mitchell J. MACHIELA, Shu-Hong LIN
  • Publication number: 20230277688
    Abstract: The present invention provides a synthetic MMACHC polynucleotide comprising a polynucleotide encoding MMACHC that is codon-optimized for expression in a human. Also provided is a polypeptide encoded by a synthetic MMACHC polynucleotide, an expression vector comprising a MMACHC gene sequence under the control of a chicken beta actin (CBA) promoter, and an expression vector comprising a synthetic MMACHC polynucleotide. Methods of treating cobalamin C deficiency and for detecting or tracking exogenous MMACHC are also provided.
    Type: Application
    Filed: November 17, 2022
    Publication date: September 7, 2023
    Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Servic
    Inventors: Charles P. Venditti, Jennifer L. Sloan
  • Publication number: 20230243905
    Abstract: An optically controlled, multi-transmitter magnetic resonance imaging system for multi-nuclear, high field applications is disclosed. In one embodiment, the MRI system may include a dual-tuned radio-frequency (RF), on-coil power amplifier for amplifying RF power signals at two or more frequencies for the multi-nuclear excitations for use in a dual-tuned coil MRI device or a nested coil MRI device. In one particular implementation, the dual-tuned amplifier of the MRI system may receive optical carrier signals through the broadband optical interface to control the on-coil amplifiers. A variable effective inductor circuit for use in tuning the dual-tuned amplifier is also disclosed. The variable effective inductor circuit includes a gallium nitride (eGaN) field effect transistor (FET) device connected to an inductor.
    Type: Application
    Filed: July 1, 2021
    Publication date: August 3, 2023
    Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Servic
    Inventor: Natalia Gudino
  • Publication number: 20230212509
    Abstract: Provided herein are methods of producing a distinct bilayer culture of retinal epithelial cells (RPE) with photoreceptor cells and/or photoreceptor precursor cells (PR/PRP). Further provided herein is a therapy comprising transplantation of the RPE and PR/PRP bilayer as well as methods for testing candidate drugs using the bilayer.
    Type: Application
    Filed: May 28, 2021
    Publication date: July 6, 2023
    Applicants: FUJIFILM Cellular Dynamics, Inc., The United States of America, as represented by the Secretary, Department of Health and Human Servic
    Inventors: Andrew DIAS, Erich BERNDT, Lucas CHASE, Juan AMARAL, Arvydas MAMINISHKIS, Kapil BHARTI
  • Publication number: 20230102223
    Abstract: Provided is a method of inhibiting viral replication, including contacting one or more cells that has been infected or contacted with a flavivirus with an effective amount of niclosamide, temoporfin, nitazoxanide, tizoxanide, erythrosin B, methylene blue. Contacting one or more cells that have been infected with a flavivirus may include administering the compound to a mammal, a human, or other subject. The flavivirus may be Dengue virus serotype 1, Dengue virus serotype 2, Dengue virus serotype 3, Dengue virus serotype 4, yellow fever virus, West Nile virus, Zika virus, Japanese encephalitis virus, tick-born encephalitis virus, Powassan virus, St. Louis encephalitis virus, or other flavivirus.
    Type: Application
    Filed: October 27, 2022
    Publication date: March 30, 2023
    Applicants: HEALTH RESEARCH, INC., THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC
    Inventors: Hongmin LI, Laura D. KRAMER, Zhong LI, Ruili HUANG, Menghang XIA
  • Publication number: 20230066585
    Abstract: Methods are disclosed for treating a cone rod homeobox transcription factor (CRX) autosomal dominant retinopathy in a subject. These methods include administering to the subject an effective amount of a nucleic acid molecule comprising a retinal specific promoter operably linked to a nucleic acid molecule encoding a CRX protein. Compositions are disclosed that include an effective amount of a nucleic acid molecule comprising a retinal specific promoter operably linked to a nucleic acid molecule encoding CRX, for use in treating a CRX autosomal dominant retinopathy in a subject. A retinal specific promoter is disclosed that includes the nucleotide sequence of SEQ ID NO: 1.
    Type: Application
    Filed: January 15, 2021
    Publication date: March 2, 2023
    Applicant: THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Servic
    Inventors: Anand Swaroop, Zhijian Wu, Suja D. Hiriyanna, Kamil Kruczek
  • Publication number: 20230053555
    Abstract: Embodiments of immunogens comprising a recombinant Mumps (MuV) F ectodomain trimer stabilized in a prefusion conformation or a recombinant Measles (MeV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also provided are embodiments of immunogens comprising chimeric proteins comprising the recombinant MuV or MeV F ectodomain trimer and one or more MuV HN or MeV H ectodomains. Also disclosed are nucleic acids encoding the immunogens and methods of their production. Methods for inducing an immune response in a subject by administering a disclosed immunogen to the subject are also provided. In some embodiments, the immune response treats or inhibits MuV and/or MeV infection in a subject.
    Type: Application
    Filed: December 11, 2020
    Publication date: February 23, 2023
    Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Servic
    Inventors: Barney Graham, Guillaume Stewart-Jones, Rebecca J. Loomis
  • Publication number: 20230025038
    Abstract: The invention features compositions and methods for the prevention or treatment of one or more strains of Chikungunya virus, as well as other alphavirus-mediated diseases.
    Type: Application
    Filed: June 27, 2022
    Publication date: January 26, 2023
    Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Servic
    Inventors: Gary J. Nabel, Wataru Akahata, Srinivas Rao
  • Publication number: 20230026627
    Abstract: A star polymer of formula O[P1]-([X]-A[P2]-[Z]-[P3])n where O is a core; A is a polymer arm attached to the core; X is a linker molecule between the core and the polymer arm; Z is a linker molecule between the end of the polymer arm and P3; P1, P2 and P3 are each independently one or more pharmaceutically active compounds that act extracellularly or intracellularly, n is an integer number; [ ] denotes that the group is optional; and at least one of P1, P2 or P3 is present.
    Type: Application
    Filed: April 16, 2020
    Publication date: January 26, 2023
    Applicants: Vaccitech North America, Inc., Institute of Macromolecular Chemistry, The United States of America, as represented by the Secretary, Department of Health and Human Servic
    Inventors: Geoffrey Lynn, Yaling Zhu, Jacob Holechek, David Wilson, Joe Francica, Richard Laga, Gabriela Muzíková
  • Publication number: 20220401622
    Abstract: Methods are disclosed for fabricating a three-dimensional engineered blood retinal barrier (BRB) comprising a choroid and retinal pigment epithelial cells. The methods include the use of bioprinting. Also disclosed is a three-dimensional engineered BRB, and its use. Methods are also disclosed for using the three-dimensional engineered BRB, such as for the treatment of retinal degeneration in a subject or screening. A three-dimensional printing insert that is adapted for bioprinting on a culture substrate sheet that is securely retained within and exposed through a printing frame is also disclosed.
    Type: Application
    Filed: August 24, 2022
    Publication date: December 22, 2022
    Applicant: THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Servic
    Inventors: Kapil Bharti, Min Jae Song, Russell Louis Quinn
  • Publication number: 20220389505
    Abstract: High efficiency methods for producing retinal pigment epithelial cells from induced pluripotent stem cells (iPSCs) are disclosed herein. The iPSCs are produced from somatic cells, including retinal pigment epithelial (RPE) cells, such as fetal RPE stem cells. In some embodiments, the iPSC include a tyrosinase promoter operably linked to a marker. Methods are disclosed for using the RPE cells, such as for treatment. Methods for screening for agents that affect RPE differentiation are also disclosed.
    Type: Application
    Filed: July 15, 2022
    Publication date: December 8, 2022
    Applicant: THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Servic
    Inventors: Kapil Bharti, Janine Davis, Arvydas Maminishkis, Marc Ferrer-Alegre, Sheldon S. Miller