Patents Assigned to The United States of America,as represented by the Secretary, Department of Health and Human Servic
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Publication number: 20190282690Abstract: Provided herein are recombinant respiratory syncytial viruses that contain mutations that make the disclosed viruses attractive vaccine candidates. The viruses disclosed contain attenuating mutations designed to have increased genetic and phenotypic stability. Desired combinations of these mutations can be made to achieve desired levels of attenuation. Exemplary vaccine candidates are described. Also provided are polynucleotides capable of encoding the described viruses, as wells as methods for producing the viruses and methods of use.Type: ApplicationFiled: May 29, 2019Publication date: September 19, 2019Applicant: The United States of America, as represented by the Secretary, Department of Health and Human ServicInventors: Peter L. Collins, Cindy L. Luongo, Ursula J. Buchholz, Brian R. Murphy
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Publication number: 20190269708Abstract: A process is provided for protecting a primate host from a self-replicating infection by an immunodeficiency retrovirus. Protection is achieved by administering to the primate host a combination of a pharmaceutically effective amount of a nucleoside reverse transcriptase inhibitor and a pharmaceutically effective amount of a nucleotide reverse transcriptase inhibitor prior to exposure to the immunodeficiency retrovirus. The administration is effective if provided in a single dose within 24 hours of the exposure. A regime of regular daily doses is also effective in providing protection against an immunodeficiency retrovirus becoming self-replicating after infecting a primate host.Type: ApplicationFiled: May 15, 2019Publication date: September 5, 2019Applicant: THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human ServicInventors: Walid Heneine, Thomas M. Folks, Robert Janssen, Ronald A. Otten, Jose Gerardo Garcia Lerma
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Publication number: 20190248732Abstract: This disclosure concerns the discovery of (R,R)- and (R,S)-fenoterol analogues which are highly effective at binding ?2-adrenergic receptors. Exemplary chemical structures for these analogues are provided. Also provided are pharmaceutical compositions including the disclosed (R,R)-fenoterol and fenoterol analogues, and methods of using such compounds and compositions for the treatment of cardiac disorders such as congestive heart failure and pulmonary disorders such as asthma or chronic obstructive pulmonary disease.Type: ApplicationFiled: April 22, 2019Publication date: August 15, 2019Applicant: The United States of America, as represented by the Secretary, Department of Health and Human ServicInventors: Irving William Wainer, Weizhong Zhu, Khalid Chakir, Rui-Ping Xiao, Darrell R. Abernethy, Farideh M. Beigi Abhari
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Publication number: 20190248880Abstract: Monoclonal antibodies and antibody fragments that specifically bind to matrilin-3, conjugates including these molecules, and nucleic acid molecules encoding the antibodies, antigen binding fragments and conjugates, are disclosed. Also disclosed are compositions including the disclosed antibodies, antigen binding fragments, conjugates, and nucleic acid molecules. Methods of treating or inhibiting a cartilage disorder in a subject, as well as methods of increasing chondrogenesis in cartilage tissue are further provided. The methods can be used, for example, for treating or inhibiting a growth plate disorder in a subject, such as a skeletal dysplasia or short stature.Type: ApplicationFiled: April 22, 2019Publication date: August 15, 2019Applicant: The United States of America, as represented by the Secretary, Department of Health and Human ServicInventors: Jeffrey Baron, Crystal Sao Fong Cheung, Julian Chun Kin Lui, Dimiter Dimitrov, Zhongyu Zhu
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Publication number: 20190233885Abstract: The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.Type: ApplicationFiled: April 10, 2019Publication date: August 1, 2019Applicants: The Children's Medical Center Corporation, The United States of America, As Represented by the Secretary, Department of Health & Human ServicInventors: Anjana Rao, Mamta Tahiliani, Kian Peng Koh, Suneet Agarwal, Aravind Iyer
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Publication number: 20190076457Abstract: A construct, or a pharmaceutically acceptable salt thereof, comprising: (a) a polyethylene glycol-block-poly(L-lysine) polymer moiety, wherein the polyethylene glycol is thiol-functionalized; (b) a cholecystokinin-B (CCK-B) receptor ligand coupled to the polyethylene glycol of the polymer moiety; and (c) a siRNA complexed with the poly(L-lysine) of the polymer moiety, wherein the construct is neutralized.Type: ApplicationFiled: March 15, 2017Publication date: March 14, 2019Applicants: Georgetown University, The United States of America, as represented by the Secretary, Department of Health & Human ServicInventors: Jill P. Smith, Stephan Stern, Abdullah Mahmud
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Publication number: 20190055593Abstract: The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.Type: ApplicationFiled: October 30, 2018Publication date: February 21, 2019Applicants: The Children's Medical Center Corporation, The United States of America, As Represented by the Secretary, Department of Health & Human ServicInventors: Anjana Rao, Mamta Tahiliani, Kian Peng Koh, Suneet Agarwal, Aravind Iyer
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Publication number: 20190048407Abstract: The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.Type: ApplicationFiled: October 26, 2018Publication date: February 14, 2019Applicants: The Children's Medical Center Corporation, The United States of America, As Represented by the Secretary, Department of Health & Human ServicInventors: Anjana Rao, Mamta Tahiliani, Kian Peng Koh, Suneet Agarwal, Aravind Iyer
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Publication number: 20180291435Abstract: The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.Type: ApplicationFiled: June 19, 2018Publication date: October 11, 2018Applicants: The Children's Medical Center Corporation, The United States of America, As Represented by the Secretary, Department of Health & Human ServicInventors: Anjana Rao, Mamta Tahiliani, Kian Peng Koh, Suneet Agarwal, Aravind Iyer
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Publication number: 20180237839Abstract: The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.Type: ApplicationFiled: April 13, 2018Publication date: August 23, 2018Applicants: The Children's Medical Center Corporation, The United States of America, As Represented by the Secretary, Department of Health & Human ServicInventors: Anjana Rao, Mamta Tahiliani, Kian Peng Koh, Suneet Agarwal, Aravind Iyer
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Publication number: 20180180602Abstract: The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.Type: ApplicationFiled: October 5, 2017Publication date: June 28, 2018Applicants: The Children's Medical Center Corporation, The United States of America, As Represented by the Secretary, Department of Health & Human ServicInventors: Anjana Rao, Mamta Tahiliani, Kian Peng Koh, Suneet Agarwal, Aravind Iyer
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Publication number: 20180148774Abstract: The present invention relates to the rapid and electricity-free, point-of-care, multiplexed detection and quantification of at least one or more nucleic acid sequences from nucleic acids corresponding to a plurality of pathogens or biomarkers using a micropatterned lateral flow device. Rapid and molecular-level sensitive differential diagnosis of a disease condition may be enabled without the need for a delayed laboratory test so that timely treatment can be administered.Type: ApplicationFiled: May 16, 2016Publication date: May 31, 2018Applicants: GODX, INC, THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICInventors: Chang Hee Kim, Wendy A. Henderson, Sarah K. Abey, Nicolaas H. Fourie, Eric G. Ferguson
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Publication number: 20180119225Abstract: Provided herein are methods and kits for detecting 5-hydroxymethylated cytosine.Type: ApplicationFiled: February 23, 2017Publication date: May 3, 2018Applicants: The Children's Medical Center Corporation, The United States of America, As Represented by the Secretary, Department of Health & Human ServicInventors: Anjana Rao, Mamta Tahiliani, Kian Peng Koh, Suneet Agarwal, Aravind Iyer
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Patent number: 9920296Abstract: The present invention provides a newly isolated bacterial strain of Paenibacillus, designated Paenibacillus alvei strain TS-15 for use as a biocontrol agent in the inhibition and/or elimination of a human foodborne pathogen, e.g., Salmonella, on a plant or plant organ, e.g., a tomato or tomato plant. Strain TS-15 or mutants thereof may also be used in the control of plant pathogens.Type: GrantFiled: November 20, 2013Date of Patent: March 20, 2018Assignee: The United States of America, as represented by the Secretary, Department of Health & Human ServicInventors: Eric W. Brown, Jie Zheng, Alexander Enurah
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Publication number: 20180044633Abstract: The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.Type: ApplicationFiled: October 2, 2017Publication date: February 15, 2018Applicants: The Children's Medical Center Corporation, The United States of America, As Represented by the Secretary, Department of Health & Human ServicInventors: Anjana Rao, Mamta Tahiliani, Kian Peng Koh, Suneet Agarwal, Aravind Iyer
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Publication number: 20180044632Abstract: The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.Type: ApplicationFiled: October 2, 2017Publication date: February 15, 2018Applicants: The Children's Medical Center Corporation, The United States of America, As Represented by the Secretary, Department of Health & Human ServicInventors: Anjana Rao, Mamta Tahiliani, Kian Peng Koh, Suneet Agarwal, Aravind Iyer
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Publication number: 20180024074Abstract: Disclosed are devices and methods for detecting a counterfeit or adulterated products and/or packaging. The device (20) includes a plurality of light sources (28) configured to emit light at a plurality of different wavelengths onto an object, at least two image acquisition devices (34a, 34b) adapted to acquire first and second image data, and first and second imaging displays (36A, 36B) configured to display the first and the second image data, respectively.Type: ApplicationFiled: February 1, 2016Publication date: January 25, 2018Applicant: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICInventors: Nicola Ranieri, Ja Cinta Shaques Batson, Stefanie Lee Kremer, Stanley Frank Platek, Mosley Fulcher, Mark R. Witkowski, Robert Duane Satzger
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Publication number: 20180000901Abstract: The invention provides a method of treating pathogenic bacterial infection (e.g., tuberculosis infection) in an animal comprising administering a peptide-based inhibitor of the STAT3-IL10 pathway or a nucleic acid encoding the peptide-based inhibitor to the animal. The invention also provides methods of treating chronic granulomatous disease and Wegener's granulomatosis in an animal comprising administering a peptide-based inhibitor of the STAT3-IL10 pathway or a nucleic acid encoding the peptide-based inhibitor to the animal.Type: ApplicationFiled: January 7, 2016Publication date: January 4, 2018Applicants: The United States of America, as represented by the Secretary, Department of Health & Human Servic, Colorado State University Research FoundationInventors: Nadya I. Tarasova, Mercedes Gonzalez-Juarrero
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Publication number: 20170176421Abstract: The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.Type: ApplicationFiled: February 23, 2017Publication date: June 22, 2017Applicants: The Children's Medical Center Corporation, The United States of America, As Represented by the Secretary, Department of Health & Human ServicInventors: Anjana Rao, Mamta Tahiliani, Kian Peng Koh, Suneet Agarwal, Aravind Iyer
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Publication number: 20170175085Abstract: The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.Type: ApplicationFiled: February 23, 2017Publication date: June 22, 2017Applicants: The Children's Medical Center Corporation, The United States of America, As Represented by the Secretary, Department of Health & Human ServicInventors: Anjana Rao, Mamta Tahiliani, Kian Peng Koh, Suneet Agarwal, Aravind Iyer