Abstract: The present invention provides methods and compositions for inducing an immune response that confers dual protection against infections by either or both of a rabies virus and a filovirus, and/or which can be used therapeutically for an existing infection with rabies virus and/or a filovirus to treat at least one symptom thereof and/or to neutralize or clear the infecting agents. In particular, the present invention provides a recombinant rabies virus vector comprising a nucleotide sequence encoding at least one filovirus glycoprotein or an immunogenic fragment thereof, as well as pharmaceutical compositions comprising the vaccine vectors.
Type:
Grant
Filed:
February 2, 2012
Date of Patent:
December 1, 2020
Assignees:
Thomas Jefferson University, The United States of America, as Represented by the Secretary, Department of Health and Human Services Services
Inventors:
Joseph E. Blaney, Jason Paragas, Peter Jahrling, Reed Johnson, Matthias Schnell