Patents Assigned to The United States of America, as represented by the Secretary, Department of Heath and Human Services
  • M971 chimeric antigen receptors
    Patent number: 11807682
    Abstract: The invention provides a chimeric antigen receptor (CAR) comprising an antigen binding domain comprising SEQ ID NOs: 1-6, a transmembrane domain, and an intracellular T cell signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal are also disclosed.
    Type: Grant
    Filed: May 8, 2020
    Date of Patent: November 7, 2023
    Assignee: The United States of America, as represented by the Secretary, Department of Heath and Human Services
    Inventors: Rimas J. Orentas, Ira H. Pastan, Dimiter S. Dimitrov, Crystal L. Mackall