Abstract: The invention provides a construct comprising two or more fusion proteins of Formulas (I)-(IV): A-(optional linker)-C-(optional linker)-B (Formula I), B-(optional linker)-D-(optional linker)-E-(optional linker)-B (Formula II), A-(optional linker)-C (Formula III), and B-(optional linker)-D-(optional linker)-E (Formula IV), wherein A denotes an antibody or antibody fragment, B denotes a single domain CD4, C denotes an immunoglobulin light chain constant region D denotes an immunoglobulin heavy chain constant region, and E denotes an Fc region or a portion thereof that is optionally defucosylated.
Type:
Application
Filed:
December 16, 2015
Publication date:
May 3, 2018
Applicants:
The United States of America, as Represented by the Secretary, Dept. of Health and Human Resources, Fudan University
Inventors:
Dimiter S. Dimitrov, Weizao Chen, Tianlei Ying