Patents Assigned to The United States of America as represented by the Secretary, Dept. of Health and Human Services National Institutes of Health
  • AAV mediated aquaporin gene transfer to treat Sjogren's syndrome
    Patent number: 10166299
    Abstract: The invention relates to a gene transfer-based method to protect a subject from Sjogren's syndrome. The method comprises administering to the subject an AAV virion comprising an AAV vector that encodes aquaporin-1 (AQP-1) protein. Also provided are AQP-1 proteins and nucleic acid molecules that encode such proteins. Also provided are AAV vectors and AAV virions that encode an AQP-1 protein.
    Type: Grant
    Filed: August 30, 2013
    Date of Patent: January 1, 2019
    Assignee: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPT. OF HEALTH AND HUMAN SERVICES NATIONAL INSTITUTES OF HEALTH
    Inventor: John Chiorini
  • Papillomavirus pseudoviruses for detection and therapy of tumors
    Patent number: 8394411
    Abstract: Disclosed herein are methods of detecting tumors, monitoring cancer therapy, and selectively inhibiting the proliferation and/or killing of cancer cells utilizing a papilloma pseudovirus or a papilloma virus-like particle (VLP).
    Type: Grant
    Filed: May 1, 2008
    Date of Patent: March 12, 2013
    Assignee: The United States of America as represented by the Secretary, Dept. of Health and Human Services National Institutes of Health
    Inventors: Jeff Roberts, Douglas R. Lowy, John T. Schiller