Patents Assigned to The United States of America, as represented by the Secretary DHHS
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Patent number: 10130700Abstract: This disclosure provides compositions that include a mixture of viral like particles (VLPs), expressing different individual influenza hemagglutinin (HA) proteins that elicit broadly reactive immune responses to a wide variety of influenza viruses. For example, the composition can include at least two different influenza VLPs, a first VLP comprising a first HA polypeptide and a second VLP comprising a second influenza HA polypeptide, wherein the first and the second HA polypeptide are different subtypes and/or are from different influenza viruses, and a pharmaceutically acceptable carrier and/or an adjuvant. Methods of using the disclosed polymeric influenza VLP compositions to stimulate an immune response against influenza viruses, for example as a pre-pandemic or a seasonal vaccine, are provided.Type: GrantFiled: May 8, 2015Date of Patent: November 20, 2018Assignee: The United States of America, as represented by the Secretary, DHHSInventor: Jeffery K. Taubenberger
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Patent number: 9464324Abstract: Methods are disclosed for determining the prognosis of a subject with an adenocarcinoma in an organ, such as the lung. The methods can include quantitating expression of a plurality of cytokines of interest, such as IL-1a, IL-1b, IL-2, IL-8, IL-10, IL-12, IL-15, IFN-? and TNF-a in the adenocarcinoma and in non-cancerous tissue in the organ. Altered expression of IL-1a, IL-1b, IL-2, IL-8, IL-10, IL-12, IL-15, IFN-? and TNF-a in the adenocarcinoma as compared to a control and in non-cancerous tissue in the organ as compared to a control determines the prognosis for the subject. Methods for determining if a therapeutic agent is effective as an anti-cancer agent are also disclosed.Type: GrantFiled: July 16, 2007Date of Patent: October 11, 2016Assignee: The United States of America as represented by the Secretary, DHHSInventors: Curtis C. Harris, Masahiro Seike, Xin Wei Wang
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Publication number: 20150203547Abstract: The inventors have identified Pfs47, a gene from the malaria parasite P. falciparum, as a key factor for survival of these parasites in the mosquito Anopheles gambiae. A. gambiae is a major natural vector of human malaria in Africa. The Pfs47 protein may allow the parasite to survive in the mosquito by manipulating the mosquito's immune system. The inventors propose the use of P47 proteins, including Pfs47 and Pvs47 as a target of vaccines or pharmaceutical agents that will block or reduce P. falciparum or P. vivax infection in A. gambiae or other anopheline mosquitoes and thus prevent further transmission of the parasites in humans.Type: ApplicationFiled: August 16, 2013Publication date: July 23, 2015Applicant: The United States of America, as represented by the Secretary, DHHSInventors: Carolina Veronica Barillas-Mury, Alvaro Molina-Cruz
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Patent number: 8041412Abstract: Systems and methods for obtaining position sensor space data regarding an endovascular prosthesis within an anatomical region of a patient include at least one position indicating element which is movable within an endovascular prosthesis is tracked by a tracking system. A guidance portion of the endovascular prosthesis constrains movement of position indicating elements within the endovascular prosthesis.Type: GrantFiled: June 11, 2007Date of Patent: October 18, 2011Assignees: Koninklijke Philips Electronics N.V., The United States of America, as represented by the Secretary DHHSInventors: Neil David Glossop, Bradford Johns Wood
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Publication number: 20090291923Abstract: The invention provides novel trioxane dimers having formulae III, IV or V: methods for their preparation, pharmaceutical compositions containing these compounds, and methods for treating cancer and/or malaria using these compounds and compositions.Type: ApplicationFiled: November 17, 2006Publication date: November 26, 2009Applicants: Johns Hopkins Universoty, The Government of the United States of America as Represented by the Secretary of the DHHS NIH, OffiInventors: Gary H. Posner, Ikhyeon Paik, Kristina Borstnik, Wonsuk Chang, Sandra Sinishtaj, William Malo, John Gaetano D'Angelo, Lauren Elaine Woodard, Alvin Solomon Kalinda, Aimee R. Usera, Lindsey Catherine Hess, Andrew Scott Rosenthal, Seongho Oh, Astrid C. Baege
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Publication number: 20090289630Abstract: An apparatus for imaging includes: a radio frequency (RF) coil array having a first RF coil and at least one additional RF coil, where the RF coil array is adapted to generate an image signal; a preamplifier having an input impedance, where the preamplifier is adapted to receive the image signal from the first RF coil; and a transformer to couple the first RF coil to the preamplifier, where impedance of the transformer is adapted to match the input impedance of the preamplifier.Type: ApplicationFiled: April 6, 2007Publication date: November 26, 2009Applicant: The Government of the United States of America, represented by The Secretary, DHHSInventors: George Nascimento, Afonso C. Silva
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Publication number: 20090208409Abstract: A detection agent, including a polymerized liposome, a lectin, and an imaging agent, can be administered to an animal for the detection of polyps in the lower gastrointestinal tract.Type: ApplicationFiled: February 13, 2009Publication date: August 20, 2009Applicant: The Government of the United States of America, as represented by the Secretary, DHHSInventors: Ronald M. Summers, Jianwu Xie, Celeste A. Roney
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Patent number: 7547712Abstract: The present invention relates methods for reducing the adverse effects of nicotine. This application describes the use of nicotine carrier conjugates in decreasing the toxic effects of nicotine on a fetus.Type: GrantFiled: February 26, 2007Date of Patent: June 16, 2009Assignees: Nabi Biopharmaceuticals, United States of America as Represented by the Secretary, DHHS Office of Technology Transfer, National Institutes of HealthInventors: Sofiane Ennifar, Scott Winston, James Terrill, Steve Fuller
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Publication number: 20090118608Abstract: A magnetic resonance imaging scanner acquires diffusion-weighted imaging data. A reconstruction engine reconstructs the acquired diffusion-weighted imaging data into diffusion-weighted image representations. A diffusion tensor engine constructs a diffusion tensor map of an area of an interest of a subject. An eigenvalue/eigenvector ordering engine obtains and orders eigenvectors and eigenvalues at each voxel. A covariance matrix determining engine constructs a covariance matrix of a major eigenvector of each voxel. A first normalized measure determining engine computes a first normalized measure. A second normalized measure determining engine computes a second normalized measure. A rendering engine generates a human-viewable display of an image representation.Type: ApplicationFiled: November 3, 2008Publication date: May 7, 2009Applicant: The Government of the United States of America, represented by The Secretary, DHHSInventor: Cheng Guan Koay
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Patent number: 5462852Abstract: An antigen capture method, and an antigen capture assay diagnostic kit, for detecting the presence or concentration of HIV in a biological sample without interference from antigen-antibody immune complexes is provided. The lysate of a biological sample obtained from an animal is contacted with a detectable amount of an antibody specifically reactive with the nucleocapsid p7 antigen or an immunoreactive fragment of the p7 antigen for a time and under conditions sufficient for p7 antigen contained in the lysate to form a p7-antibody complex. The presence or concentration of this p7-antibody complex is determined to detect or quantitate the presence of HIV in the biological sample. Uses of this assay and method include detecting the presence of HIV infection in an infant born to an HIV-infected mother, monitoring the progression of HIV infection, and evaluating the effectiveness of an anti-HIV treatment administered to an animal, such as a human.Type: GrantFiled: October 28, 1992Date of Patent: October 31, 1995Assignee: The Government of the United States of America, as Represented by the Secretary, DHHSInventors: Larry O. Arthur, Louis E. Henderson
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Patent number: 5441941Abstract: Certain new 1,2-dihydroellipticine compounds having activity against CNS specific cancer cell lines because of their ease of passage across the blood-brain barrier are disclosed along with formulations and methods for treating CNS cancers employing these compounds.Type: GrantFiled: December 21, 1993Date of Patent: August 15, 1995Assignees: The United States of America as represented by the Secretary of DHHS, Purdue Research FoundationInventors: Rudiger D. Haugwitz, Venkatachiala L. Narayanan, Mark Cushman, Jurjus Jurayj