Abstract: The present invention relates to a method of producing non-infections parvovirus capsids and to diagnostic assays and vaccines utilizing same. The invention further relates to recombinant baculoviruses encoding parvovirus structural proteins and host cells infected therewith. The invention also relates to a method of packaging and delivering genetic information utilizing the noninfectious capsids.

Abstract: 3.beta.-[4-iodophenyl]-tropan-2.beta.-carboxylic acid methyl ester tartrate is a high affinity binding ligand for cocaine receptors in mammalian brains. It and its congeners may be employed for imaging and other brain scanning techniques that allow the determination of the presence of cocaine receptors, such as dopamine and serotonin transporters and the like.

Abstract: A polymeric composition capable of releasing nitric oxide including a polymer and a nitric oxide-releasing N.sub.2 O.sub.2.sup.- functional group bound to the polymer; pharmaceutical compositions including the polymeric composition; and methods for treating biological disorders in which dosage with nitric oxide is beneficial. The compositions can be used as and/or incorporated into implants, injectables, condoms, prosthesis coatings, patches, and the like for use in a wide variety of medical applications.

Abstract: The invention provides sequence analyses for recent strains of Influenza Type B Virus.

Abstract: Amino acid and cDNA sequences of a plurality of human bone matrix proteins and their uses have been described.

Abstract: 5,6-dihydro-5-azacytidine phosphoramidite is useful in the synthesis of oligonucleotides and DNA containing dihydro-5-aza- and 5-azacytosine bases. The modified oligonucleotides which contain 5-azacytosine residues at specific sites can be used to determine the mechanism of selective gene activation and the relationship existing between the presence of the triazine base and inhibition of DNA methylation.

Abstract: The present invention relates to a method for desensitizing a subject animal, which comprises administering to the subject animal a therapeutically effective desensitizing amount of resiniferatoxin for desensitizing the subject animal to neurogenic inflammation, to chemically and thermally induced pain and to responses involving sensory afferent pathways sensitive to capsaicin and to responses involving the hypothalamic temperature control region, and a pharmaceutically acceptable carrier therefor.

Abstract: New polysubstituted diethylenetriaminepentaacetic acid chelates and protein conjugates of the same are described together with the methods of preparing such compounds. A method of delivering radiolabelled compound of the present invention to a target site while minimizing the distribution of the compound to non-targeted organs or tissues is also disclosed.

Abstract: The present invention relates to transmission-blocking vaccines against malaria. Vaccines of the present invention contain a recombinant Pfs25 Plasmodium falciparum protein produced by yeast cells and to yeast cells producing the protein. Mice and monkeys inoculated with the yeast-expressed Pfs25 of the present invention have developed antibodies with transmission-blocking activity. The present invention also relates to methods of preventing or treating malarial infections using the vaccines of the present invention.

Abstract: The present invention relates to a method of treating chronic fatigue syndrome not associated with an HIV infection. In the method of the present invention patients are administered a pharmaceutically acceptable carrier together with(1) a neuropsychiatrically effective amount of a linear peptide of formula (I):R.sup.a -Ser-Thr-Thr-Thr-Asn-Tyr-R.sup.6 (I)whereinR.sup.a is Ala, D-Ala or Cys-Ala-, andR.sup.6 is Thr, Thr-amide, Thr-Cys or Thr-Cys-amide,or a derivative of the peptide or a physiologically acceptable salt thereof; or(2) a neuropsychiatrically effective amount of a linear peptide of formula (II):R.sup.1 -R.sup.2 -R.sup.3 -R.sup.4 -R.sup.5 (II)whereinR.sup.1 is X-Y or Y when Y is Thr-, Ser-, Asn-, Leu-, Ile-, Arg- or Glu-, and X is Cys;R.sup.2 is Thr-, Ser- or Asp;R.sup.3 is Thr, Ser, Asn, Arg, Gln, Lys or Trp;R.sup.4 is Tyr; andR.sup.

Abstract: A method of inactivating a lipid virus in a protein carrier by contacting said virus for an abbreviated period of time and ambient temperature with a halohydrocarbon solvent or treating agent, preferably chloroform, in an amount of 5% v/v to 50% v/v. Preferred lipid viruses are Hepatitis B virus (HBV) and non-A, non-B Hepatitis (NANBH).

Abstract: A centrifugal blood component separator with a spiral helically inclined rotor chamber. The apparatus uses continuous blood flow-through without rotating seals. At the lower end of the helical rotor chamber there are terminals for blood input and packed red blood cell output, whereas at the higher end there is a terminal for plasma. Intermediate outlet terminals may be provided for white blood cells and platelets.

Abstract: A print-washing tank with generally rectangular spirally-looped pipes in parallel vertical arrays, fed by a horizontal input conduit in the upper portion of the tank, the arms of the pipes having holes to spray photographic prints on both sides with jets of water, the prints being supported between the vertical spray loops, using either wire baskets or being supported directly in the narrow vertical spaces between the spirally looped pipes. A drain pipe array is provided at the bottom of the tank, having a plurality of widely spaced intake ports and leading to a vertical siphon exit conduit near the back wall of the tank and which may be either inside the tank or may be located externally. The top loop of the siphon drain system is located slightly below the level of the water input pipe.

Abstract: This invention relates to a method of inactivating a non-A, non-B hepatitis agent by means of formalin utilized in extended treatment. The range of formalin treatment utilizes a concentration of 1:1,000-1:10,000, preferred 1:1,000, and the duration of treatment is from 24-120 hours at any temperature with a preferred 96 hours (4 days) at 37.degree..+-.4.degree. C. This formalin-treated or otherwise inactivated agent, or portions of the agent, may be later used to produce a vaccine against non-A, non-B hepatitis.