Patents Assigned to The United States of America as Represented by the Secretary of Health (NIH)
  • Methods for using antibodies for 3? iso-LM1 and 3?, 6?-iso-LD1tumor gangliosides
    Patent number: 10052382
    Abstract: High affinity antibodies were made to gangliosides expressed on tumor cells. The antibodies can be used analytically, diagnostically, therapeutically, and theranostically. The antibodies may be used to target cytotoxic reagents to tumor cells, thus minimizing full-body toxicity. The antibodies may also be used with out added cytotoxin. The antibodies may be detectably labeled or labelable for analytic and diagnostic purposes. The combination of specificity and affinity of the antibodies render them particularly useful.
    Type: Grant
    Filed: June 2, 2016
    Date of Patent: August 21, 2018
    Assignees: Duke University, The United States of America as Represented by the Secretary of Health (NIH)
    Inventors: Darell Bigner, Chien-Tsun Kuan, Ira H. Pastan, Hailan Piao