Patents Assigned to The United States of America as represented by the Secretary
  • Patent number: 11761116
    Abstract: A method of performing HVPE heteroepitaxy comprises exposing a substrate to a carrier gas, a first precursor gas, a Group II/III element, and ternary-forming gasses (V/VI group precursor), to form a heteroepitaxial growth of a binary, ternary, and/or quaternary compound on the substrate; wherein the carrier gas is H2, wherein the first precursor gas is HCl, the Group II/III element comprises at least one of Zn, Cd, Hg, Al, Ga, and In; and wherein the ternary-forming gasses comprise at least two or more of AsH3 (arsine), PH3 (phosphine), H2Se (hydrogen selenide), H2Te (hydrogen telluride), SbH3 (hydrogen antimonide, or antimony tri-hydride, or stibine), H2S (hydrogen sulfide), NH3 (ammonia), and HF (hydrogen fluoride); flowing the carrier gas over the Group II/III element; exposing the substrate to the ternary-forming gasses in a predetermined ratio of first ternary-forming gas to second ternary-forming gas (1tf:2tf ratio); and changing the 1tf:2tf ratio over time.
    Type: Grant
    Filed: October 17, 2022
    Date of Patent: September 19, 2023
    Assignee: United States of America as represented by the Secretary of the Air Force
    Inventor: Vladimir Tassev
  • Patent number: 11761892
    Abstract: Building blocks are provided for on-chip chemical sensors and other highly-compact photonic integrated circuits combining interband or quantum cascade lasers and detectors with passive waveguides and other components integrated on a III-V or silicon. A MWIR or LWIR laser source is evanescently coupled into a passive extended or resonant-cavity waveguide that provides evanescent coupling to a sample gas (or liquid) for spectroscopic chemical sensing. In the case of an ICL, the uppermost layer of this passive waveguide has a relatively high index of refraction that enables it to form the core of the waveguide, while the ambient air, consisting of the sample gas, functions as the top cladding layer. A fraction of the propagating light beam is absorbed by the sample gas if it contains a chemical species having a fingerprint absorption feature within the spectral linewidth of the laser emission.
    Type: Grant
    Filed: August 20, 2021
    Date of Patent: September 19, 2023
    Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Jerry R. Meyer, Igor Vurgaftman, Chadwick Lawrence Canedy, William W. Bewley, Chul Soo Kim, Charles D. Merritt, Michael V. Warren, R. Joseph Weiblen, Mijin Kim
  • Patent number: 11764466
    Abstract: The embodiments are directed to radio frequency witness films. The embodiments include a unit cell in a three-dimensional coordinate frame of reference defined by an x-axis, a y-axis, and a z-axis. The unit cell is centered at an origin of the three-dimensional coordinate frame of reference. The unit cell includes a substrate, a first conductive layer, a dielectric layer, and a second conductive layer. The second conductive layer has at least two microstrip extensions that are perpendicular to each other in the x-y plane.
    Type: Grant
    Filed: January 25, 2022
    Date of Patent: September 19, 2023
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Zachary A. Sechrist, Christopher G. Yelton, Mark B. Moran, Linda F. Johnson, Joseph E. Estevez, Gretchen H. Hefley
  • Patent number: 11760794
    Abstract: Antibodies and antigen binding fragments that specifically bind to P. falciparum circumsporozoite protein and neutralize P. falciparum are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. The disclosed antibodies, antigen binding fragments, nucleic acids and vectors can be used, for example, to inhibit a P. falciparum infection.
    Type: Grant
    Filed: April 28, 2021
    Date of Patent: September 19, 2023
    Assignees: The United States of America, as Represented by the Secretary, Department of Health and Human Services, Sanaria Inc.
    Inventors: Robert Seder, Neville Kisalu, Azza Idris, Barbara Flynn, Stephen Hoffman
  • Patent number: 11761740
    Abstract: A drone disabling device includes a plurality of streamer launch tubes having at least one streamer device positioned therein. A barrel housing is configured to hold the plurality of launch tubes within streamer launch barrels. An ignition system is configured to ignite propellant within the launch tubes and launch the streamer devices from the barrel housing such that one or more propellers of a hostile drone will become entangled and disabled. A parachute connected to the streamer device is deployed as the drone descends to protect people and property on the ground and to preserve the drone for intelligence gathering after landing.
    Type: Grant
    Filed: August 24, 2021
    Date of Patent: September 19, 2023
    Assignee: United States of America as represented by the Secretary of the Air Force
    Inventors: Adam Wilmer, Derrick Jochmans, Matthew Fleckenstein, James Westfall, James Roberts, Nicholas Pingel, Michael Anderson
  • Publication number: 20230287067
    Abstract: The invention provides human immunogenic epitopes of HEMO and HHLA2 human endogenous retroviruses (HERVs), which can be used as a peptide, polypeptide (protein), and/or in a vaccine or other composition for the prevention or therapy of cancer. The invention further provides a nucleic acid encoding the peptide or polypeptide (protein), a vector comprising the nucleic acid, a cell comprising the peptide, polypeptide (protein), nucleic acid, or vector, and compositions thereof.
    Type: Application
    Filed: January 21, 2021
    Publication date: September 14, 2023
    Applicant: The United States of America,as represented by the Secretary,Department of Health and Human Services
    Inventors: Jeffrey Schlom, Duane H. Hamilton, Claudia M. Palena, Renee N. Donahue
  • Publication number: 20230286964
    Abstract: A series of bio-based benzoxazine monomers were developed. These benzoxazine monomers are liquid at room temperature with good processability due to their low viscosities at or near room temperature and their relatively low polymerization temperatures. Cured materials made from these bio-based benzoxazines have excellent thermal and mechanical properties.
    Type: Application
    Filed: July 23, 2021
    Publication date: September 14, 2023
    Applicants: DREXEL UNIVERISTY, The United States of America as Represented by the Secretary of the Army
    Inventors: Giuseppe Raffaello Palmese, Mengwen Yu, John Joseph La Scala
  • Publication number: 20230287055
    Abstract: Recombinant paramyxoviruses including a viral genome encoding a heterologous gene are provided. In several embodiments, the recombinant paramyxovirus is a recombinant parainfluenza virus, such as a recombinant PIV3 including a viral genome encoding a heterologous respiratory syncytial virus F ectodomain linked to the transmembrane domain and the cytoplasmic tail of the F protein from the PIV3. Nucleic acid molecules including the genome of a recombinant paramyxoviruses are also provided. The recombinant viruses may advantageously be used in vaccine formulations, such as for vaccines against parainfluenza virus and respiratory syncytial virus.
    Type: Application
    Filed: January 31, 2023
    Publication date: September 14, 2023
    Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Ser.
    Inventors: Peter Collins, Bo Liang, Shirin Munir, Anne Schaap Nutt, Ursula Buchholz, Natalie Mackow, Peter Kwong, Barney Graham, Jason McLellan
  • Publication number: 20230290467
    Abstract: The invention features methods that are useful for treatment of a patient at increased risk for infection and for selecting a patient for treatment for an infection. In various embodiments, the infection is coronavirus disease 2019 (COVID-19), sepsis, or other respiratory infections.
    Type: Application
    Filed: March 14, 2023
    Publication date: September 14, 2023
    Applicants: The Broad Institute, Inc., The United States of America, as represented by the Secretary, Department of Health and Human Servic, Yale University, The General Hospital Corporation
    Inventors: Pradeep NATARAJAN, Giulio GENOVESE, Seyedeh Maryam ZEKAVAT, Mitchell J. MACHIELA, Shu-Hong LIN
  • Patent number: 11752138
    Abstract: The disclosure provides methods of treating a patient having primary hyperoxaluria or idiopathic hyperoxaluria comprising administering a therapeutically effective amound of compound of the formula and pharmaceutically acceptable salts, solvates, and hydrates thereof to the patient. The variables, e.g. ring A, n, R, R3, R10, X, Y, and Z are defined herein. These compounds act as lactate dehydrogenase inhibitors and are useful inhibiting the conversion of glyoxylate to oxalate. When administered to a patient having a disease or disorder associated with elevated oxalate levels, such as PH type 1, type 2, or type 3 or idiopathic hyperoxaluria the compounds prevent or substantially reduce the amount and buildup of oxalate the patient's kidneys, bladder, urinary tract and other parts of the patient's body.
    Type: Grant
    Filed: May 17, 2021
    Date of Patent: September 12, 2023
    Assignees: VANDERBILT UNIVERSITY, THE UAB RESEARCH FOUNDATION, THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventors: Matthew Hall, Daniel J. Urban, John Knight, Ross Holmes, Kyle David Wood, Alex Waterson, Victor M. Darley-Usmar, Leonard M. Neckers
  • Patent number: 11755842
    Abstract: The present invention relates to a system that uses natural language processing (NLP) to read data from a file and analyze the data based on user defined parameters. According to an illustrative embodiment of the present disclosure, a system can process and analyze a data file by finding trending themes across data entries. According to a further illustrative embodiment of the present disclosure, the system can search for reoccurring words/phrases based on Ngrams (i.e. n-grams). The system can be adapted to search for Ngrams of varying length depending on the information sought and can sort the results by Ngram length.
    Type: Grant
    Filed: January 25, 2021
    Date of Patent: September 12, 2023
    Assignee: The United States of America, as Represented by the Secretary of the Navy
    Inventor: Alicia L Scott
  • Patent number: 11758332
    Abstract: A biodegradable microphone has a housing fabricated from a biodegradable ferromagnetic filament. The ferromagnetic filament is based on a biodegradable polymer having embedded magnetic materials. The housing has a body portion, an open first end and an opposite second end having a central opening. A permanent magnet is removably lodged within the central opening. The ferromagnetic filament and the magnet cooperate to produce a magnetic field within the housing interior. A biodegradable diaphragm is joined to the open first end of the housing. The diaphragm has an interior side facing the housing interior. A biodegradable coil is joined to the interior side and extends downward into the housing interior and is in proximity to the permanent magnet. Vibrations of the diaphragm cause a reciprocating motion of the coil within the magnetic field thereby inducing an electrical current in the coil.
    Type: Grant
    Filed: April 15, 2022
    Date of Patent: September 12, 2023
    Assignee: United States of America as represented by the Secretary of the Navy
    Inventors: Joshua M Kogot, April M Hirsch
  • Patent number: 11754505
    Abstract: Disclosed are methods that, by not physically touching a material being measured, can measure the material's differential response quite accurately. A collimated light shines on the material under test, is reflected off it, and is then captured by a device that records the position where the reflected light is captured. This process is done both before and after the material is processed in some way (e.g., by applying a coat of paint). The change in position where the reflected light is captured is used in calculating the deflection of the material as induced by the process. This measured induced deflection is then used to accurately determinate the stress introduced into the material by the process. Other characteristics of the material under test, such as aspects of the material composition of a bi-metallic strip, for example, may also be determined from a deflection measurement.
    Type: Grant
    Filed: September 29, 2021
    Date of Patent: September 12, 2023
    Assignee: UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY
    Inventors: Rebekah C Wilson, Benjamin C Masters
  • Patent number: 11753163
    Abstract: Embodiments are directed to releasing smaller unmanned aerial vehicles from larger unmanned aerial vehicles. Apparatus and system embodiments are disclosed for physically retaining and ejecting the smaller unmanned aerial vehicles, including the communication networks associated with the command and control of both the smaller unmanned aerial vehicles and the larger unmanned aerial vehicles.
    Type: Grant
    Filed: May 4, 2021
    Date of Patent: September 12, 2023
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Nicholas H. Albrecht, Vincent R. Schuetz, Pavel K. Rybakov, Chase A. York, Scott D. Slaughter, Derek A. Hamel
  • Patent number: 11753670
    Abstract: Disclosed are compositions, methods, and kits for performing cell-free RNA transcription and/or cell-free protein synthesis (CFPS). The disclosed compositions, methods, and kits include or utilize components prepared from Yersinia pestis species such as cellular extracts from Yersinia pestis.
    Type: Grant
    Filed: July 12, 2022
    Date of Patent: September 12, 2023
    Assignee: The United States of America as Represented by the Secretary of the Army
    Inventors: Aleksandr E. Miklos, Katherine A. Rhea, Nathan D. McDonald, Stephanie D. Cole, Patricia E. Buckley
  • Patent number: 11754785
    Abstract: Methods and apparatuses for mode conversion. An apparatus that includes a substrate, a first waveguide, a second waveguide, a micro-electro-mechanical systems (MEMS) perturber, and a controller is provided. The first waveguide is formed on the substrate includes: (i) an input section, (ii) a bend section, and (iii) an output section. The second waveguide is also formed on the substrate and is disposed adjacent to a portion of the input section of the first waveguide. A portion of the second waveguide is separated from the input section of the first waveguide by a coupling gap. The perturber is disposed above the first waveguide and configured to move between a first position that is distal from a surface of the input section of the first waveguide and a second position that is closer to the surface of the input section of the first waveguide than the second position. The controller is configured to control a movement of the perturber between the first position and the second position.
    Type: Grant
    Filed: August 20, 2021
    Date of Patent: September 12, 2023
    Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Marcel W. Pruessner, Dmitry A. Kozak, Todd H. Stievater, Brian J. Roxworthy
  • Patent number: 11753408
    Abstract: Disclosed are compounds of formula (I) and formula (II): wherein R1, R2, A, and B are as defined herein. Also disclosed is a method of blocking transmission of a Plasmodium parasite and a method of treating or preventing malaria comprising administering to an animal an effective amount of a first compound of formula (I) or (II) either alone or in combination with a second compound selected from elesclomol, NSC174938, NVP-AUY922, Maduramicin, Narasin, Alvespimycin, Omacetaxine, Thiram, Zinc pyrithione, Phanquinone, Bortezomib, Salinomycin sodium, Monensin sodium, Dipyrithione, Dicyclopentamethylene-thiuram disulfide, YM155, Withaferin A, Adriamycin, Romidepsin, AZD-1152-HQPA, CAY10581, Plicamycin, CUDC-101, Auranofin, Trametinib, GSK-458, Afatinib, and Panobinostat.
    Type: Grant
    Filed: April 22, 2021
    Date of Patent: September 12, 2023
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, Loyola University of Chicago
    Inventors: Wenwei Huang, Hao Li, Wei Sun, Xiuli Huang, Paresma R. Patel, Hangmao Sun, Wei Zheng, Xiao Lu, Philip E. Sanderson, Myunghoon Kim, Meghan J. Orr, Gregory J. Tawa, Kim C. Williamson
  • Patent number: 11754583
    Abstract: Apparatuses and methods for generating trace vapors are provided. The apparatus includes a controller and an oven. The controller includes: a processor, a memory storing at least one control program, a clean solution supply port constructed to output a clean solution, an analyte solution supply port constructed to output an analyte solution, a carrier gas inlet port constructed to receive a carrier gas, and a plurality of carrier gas supply controllers constructed to output the carrier gas.
    Type: Grant
    Filed: February 14, 2019
    Date of Patent: September 12, 2023
    Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Greg Collins, Susan Rose-Pehrsson, Michael Malito, Braden C. Giordano, Adam L. Lubrano, Mark H. Hammond, Cy Tamanaha
  • Patent number: 11753627
    Abstract: The invention relates to a dengue virus tetravalent vaccine containing a common 30 nucleotide deletion (?30) in the 3?-untranslated region of the genome of dengue virus serotypes 1, 2, 3, and 4, or antigenic chimeric dengue viruses of serotypes 1, 2, 3, and 4.
    Type: Grant
    Filed: September 1, 2020
    Date of Patent: September 12, 2023
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Stephen S. Whitehead, Brian R. Murphy, Lewis Markoff, Barry Falgout, Joseph Blaney, Kathryn Hanley, Ching-Juh Lai
  • Patent number: 11754547
    Abstract: A biorecognition element for rapid detection of fuel biocontamination. The biorecognition element is a biorecognition element selected from SEQ. ID No. 2 through SEQ. ID No. 24, SEQ. ID No. 22 through SEQ. ID No. 44, SEQ. ID No. 46 through SEQ. ID No. 57, SEQ. ID No. 59 through SEQ. ID No. 196 or SEQ. ID No. 198 through SEQ. ID No. 332.
    Type: Grant
    Filed: May 18, 2021
    Date of Patent: September 12, 2023
    Assignee: United States of America as represented by the Secretary of the Air Force
    Inventors: Oscar N. Ruiz, Thusitha S Gunasekera, Osman Radwan