Abstract: A peritoneal-based (“bloodless”) artificial kidney processes peritoneal fluid without need for additional fluids (“waterless”). Fluid is separated into a protein-rich stream and a protein-free stream. The protein-rich stream is regenerated using a sorbent assembly, and its protein composition can be modified by removal of selected protein(s) (“dialysate-pheresis”). It is then reconstituted with additives and returned into the peritoneal cavity, thereby reducing protein-loss and providing oncotic-pressure for ultrafiltration. The protein-free stream is used to produce free water, and an alkaline or acid fluid for optimization of the composition of the regenerated stream. The unused protein-free stream can be used to “reverse flush” the separator to maintain its patency and the excess discarded for fluid-balance regulation.
Type:
Grant
Filed:
May 4, 2010
Date of Patent:
January 17, 2012
Assignees:
The Regents of the University of California, The United States of America as represented by the United States Department of Veterans Affairs
Abstract: A method of antagonizing inhibition effects of alcohol on cell adhesion is disclosed comprising contacting a cell-adhesion molecule expressing cell with an effective amount of a compound, wherein the compound comprises an alcohol selected from the group consisting of 3-pentanol, 2-pentanol, cyclopentanol, 4-methyl-1-pentanol, 2-methyl-2-pentanol, and 2,6-diisopropylphenol.
Type:
Grant
Filed:
October 16, 2002
Date of Patent:
December 20, 2005
Assignees:
President and Fellows of Harvard College, The United States of America as represented by the United States Department of Veterans Affairs
Inventors:
Michael F. Wilkemeyer, Michael E. Charness
Assignees:
The United States of America as represented by the United States Department of Veterans Affairs, Medical College of Wisconsin, University of South Florida
Inventors:
Pascal Malassigne, Jeffrey Harrow, Robert Jensen, John Erdman
Abstract: A method of preparing multiple doses of a pharmaceutical solution, such as ranibizumab, from a single-dose container, includes providing a sterile enclosed area with a plurality of unused sterile syringes, a decapper, and a plurality of sterile bags, opening a single-use container of a pharmaceutical solution in the enclosed area, withdrawing a first portion of the pharmaceutical solution using one of the sterile syringes, withdrawing a second portion of the pharmaceutical solution using a second of the sterile syringes, repeating the previous step for the remaining pharmaceutical solution using the remaining sterile syringes, and placing the sterile syringes containing portions of the pharmaceutical solution individually in the sterile bags.
Type:
Grant
Filed:
May 12, 2009
Date of Patent:
January 4, 2011
Assignee:
The United States of America as represented by the United States Department of Veterans Affairs
Inventors:
Robert A. Malmstrom, Joy L. Meier, Jannet M. Carmichael