Patents Assigned to THE UNITED STATES OF AMERICA AS REPRESENTED DEPARTMENT OF VETERANS AFFAIRS
  • Method for assessing fall risk based on tracking data of a moving target
    Publication number: 20180235518
    Abstract: Techniques are provided for assessing a risk of fall based on tracking data of a subject tracking a moving target. Tracking data of a first subject to the moving target is determined based on sensing a body of the first subject that measure a position of one or more body segments at time increments over a time period. A response of the first subject is characterized based on the tracking data of the first subject. Tracking data of a second subject to the moving target is determined based on sensing a body of the second subject that measure a position of one or more body segments at each time increment over the time period. A risk of fall of the second subject is determined based on the response of the first subject and the response of the second subject.
    Type: Application
    Filed: August 17, 2016
    Publication date: August 23, 2018
    Applicants: University of Maryland, Baltimore, The United States of America as Represented by the Department of Veterans Affairs
    Inventor: Joseph E. Barton
  • Cell penetrating anti-guanosine antibody based therapy for cancers with Ras mutations
    Patent number: 10040867
    Abstract: It has been established that cancer cells with oncogenic mutants in the small GTPase K-Ras are susceptible to antibodies that bind intracellular guanosine, but delivery of antibodies into cells can be challenging. A subset of lupus autoantibodies is associated with anti-guanosine activity, and is capable of cellular penetration. These antibodies have potential as therapeutic agents targeted towards K-Ras associated malignancies.
    Type: Grant
    Filed: March 4, 2015
    Date of Patent: August 7, 2018
    Assignees: Yale University, The United States of America, as Represented by The Department of Veterans Affairs
    Inventors: James E. Hansen, Richard H. Weisbart, Melissa Young, Philip W. Noble
  • Tomatidine, analogs thereof, compositions comprising same, and uses for same
    Patent number: 10022386
    Abstract: In one aspect, the invention relates to methods for promoting muscle hypertrophy or decreasing adiposity by providing to an animal in need thereof an effective amount of a compound. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: December 22, 2015
    Date of Patent: July 17, 2018
    Assignees: UNIVERSITY OF IOWA RESEARCH FOUNDATION, THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Christopher M. Adams, Michael C. Dyle, Michael Welsh
  • Methods for treating diet-induced obesity by decreasing or inhibiting P2Y2 purinergic receptor expression or activity
    Patent number: 10024846
    Abstract: The invention provides a method for treating or preventing diet-induced obesity in a subject comprising administering an agent in an effective amount so that expression or activity of the P2Y2 receptor is decreased or inhibited in the subject thereby treating or preventing diet-induced obesity in the subject.
    Type: Grant
    Filed: April 27, 2015
    Date of Patent: July 17, 2018
    Assignee: The United States of America as represented by the Department of Veterans Affairs
    Inventors: Bellamkonda K. Kishore, Yue Zhang, Carolyn M. Ecelbarger
  • Compounds, compositions and associated methods comprising 3-aryl quinolines
    Patent number: 10023538
    Abstract: Compounds, compositions and methods useful for treating infectious diseases are provided. In particular, 3-aryl quinoline compounds, their synthesis, pharmaceutical compositions thereof and methods of treating infectious diseases such as malaria, are disclosed.
    Type: Grant
    Filed: February 23, 2017
    Date of Patent: July 17, 2018
    Assignees: The United States of America as represented by the Department of Veterans Affairs, Oregon Health and Science University
    Inventors: Michael K. Riscoe, Rolf W. Winter, Sovitj Pou, David J. Hinrichs, Jane Xu Kelly, Yuexin Li, Aaron Nilsen
  • Hydrogel tissue expanders
    Patent number: 10011689
    Abstract: The present invention provides tissue expanders comprising biodegradable, chemically cross-linked hydrogels which are elastic in the dry state. These biocompatible tissue expanders are self-inflating and membrane-free. They swell slowly and elicit minimal negative tissue responses, while allowing for rapid and easy manipulation by the surgeon at the time of emplacement.
    Type: Grant
    Filed: April 13, 2015
    Date of Patent: July 3, 2018
    Assignees: Akina, Inc., THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Kinam Park, Clark Tobias Barco, Haesun Park, Yourong Fu, John Solomon Garner
  • Preparation and use of a composition for prevention and mitigation of the effects of radiation
    Patent number: 9993456
    Abstract: Plant extracts, compositions, pharmaceutical compositions and methods of making and using the same are provided herein. The compositions comprise ?-tocotrienol (GT3) and ?-tocotrienol (DT3) in ratios wherein the DT3 is predominate. The compositions are useful for radioprotection and radiomitigation in subjects in need thereof.
    Type: Grant
    Filed: September 15, 2014
    Date of Patent: June 12, 2018
    Assignees: The Board of Trustees of the University of Arkansas, Universidad Tecnica Particular De Loja, The United States of America as Represented by the Department of Veterans Affairs
    Inventors: Cesar M. Compadre, Philip Breen, Nukhet Aykin-Burns, Martin Hauer-Jensen, Raul G. Enriquez, Sujay Kharade, Omar Malagon, Yadira Ordonez, Edgar Ojeda, Shraddha Thakkar, E. Nathalie Pineda, Darin Jones
  • Methods for modulating cyclic nucleotide-mediated signaling in cardiac myocytes and compositions
    Patent number: 9994830
    Abstract: The invention provides a polypeptide possessing anti-hypertrophic activity in a cardiac myocyte, wherein the polypeptide is a mutant variant derived from wild-type PDE3A1 protein and wherein the wild-type PDE3A1 protein has the amino acid sequence given in SEQ ID NO:1 at amino acid position 146 to 1141.
    Type: Grant
    Filed: July 15, 2015
    Date of Patent: June 12, 2018
    Assignee: The United States of America as Represented by the Department of Veterans Affairs
    Inventors: Matthew Movsesian, Manuela Zaccolo
  • Collapsible manual wheelchair system for improved propulsion and transfers
    Patent number: 9980863
    Abstract: A manual wheelchair including a collapsible frame having a first lateral member that is connected to first and second braces at their respective first ends. A drive wheel axle extends along a first axis of rotation and engages a drive wheel, the first brace, and a portion of a transmission. A push rim axle extends along a second axis of rotation and engages a push rim wheel, the second brace, and a portion of the transmission, which transmits rotation of the push rim to rotation of the drive wheel. The collapsible frame additionally includes a second lateral member that is connected to the first and second braces as their respective second ends. The first and second braces are configured to release the second lateral member to collapse the manual wheelchair.
    Type: Grant
    Filed: October 23, 2017
    Date of Patent: May 29, 2018
    Assignee: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Andrew H. Hansen, Gary D. Goldish, Eric Nickel
  • Cellular seeding and co-culture of a three dimensional fibroblast construct
    Patent number: 9976123
    Abstract: The present invention provides methods for cellular seeding onto three-dimensional fibroblast constructs, three-dimensional fibroblast constructs seeded with muscle cells, and uses therefore.
    Type: Grant
    Filed: May 21, 2015
    Date of Patent: May 22, 2018
    Assignees: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA, THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Jordan Lancaster, Steve Goldman
  • System for analysis of complex rhythm disorders
    Patent number: 9955879
    Abstract: A system to generate a representation of a rhythm disorder includes a plurality of sensors disposed at multiple locations spatially in relation to the heart, wherein cardiac information signals are sensed. A processor receives and analyzes the activation onsets of the cardiac information signals to determine an arrangement of activation onsets. A representation that indicates the clinical source of the rhythm disorder is generated based on the arrangement of the activation onsets.
    Type: Grant
    Filed: June 8, 2016
    Date of Patent: May 1, 2018
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Sanjiv Narayan, Wouter-Jan Rappel
  • Method and apparatus for providing deficit-adjusted adaptive assistance during movement phases of an impaired joint
    Patent number: 9943459
    Abstract: A method includes determining, on a processor, a current movement phase for a compound joint function based on sensor data. The method further includes determining, on the processor, a respective robot state parameter trace for each movement phase in a normal and impaired subject. The method further includes determining, on the processor, a deficit parameter for each movement phase. The method further includes determining, on the processor, an adaptive magnitude for the robot applied torque based on the deficit parameter of the current movement phase. The method further includes applying, to the robot joint, the adaptive magnitude for the robot applied torque for the current movement phase, based on an adaptive timing for the current movement phase. An apparatus is also described for providing deficit-adjusted adaptive assistance during movement phases of the impaired joint.
    Type: Grant
    Filed: November 20, 2014
    Date of Patent: April 17, 2018
    Assignees: University of Maryland, Baltimore, The United States of America as Represented by the Department of Veterans Affairs
    Inventors: Anindo Roy, Larry W. Forrester, Richard F. Macko
  • Manganese ion coated nanoparticles for delivery of compositions into the central nervous system by nasal insufflation
    Patent number: 9938526
    Abstract: The compositions and methods of the disclosure particularly target the divalent metal transporter expressed on olfactory nerve terminals to transport divalent cation-coated or cation-containing nanoparticles to all regions of brain. It has been found that such divalent cation-containing nanoparticles, including those nanoparticles comprising manganese have affinity for the metal transport receptor proteins. Although this receptor has particular affinity for manganese, it is contemplated that other divalent ions, including magnesium, calcium, and the like may also be bound to such receptors leading to transport of the nanoparticles into the intracellular cytoplasm. Nanoparticles have been developed, therefore, as vehicles for parenteral delivery of genes, proteins and drugs.
    Type: Grant
    Filed: May 24, 2016
    Date of Patent: April 10, 2018
    Assignees: University of South Florida, The United States of America as Represented by the Department of Veterans Affairs Office of General Counsel—PSG IV (024)
    Inventors: Juan Sanchez-Ramos, Vasyl Sava, Shijie Song, Shyam S. Mohapatra, Subhra Mohapatra
  • Desethylhydroxychloroquine for the treatment of diseases associated with inflammation
    Patent number: 9931335
    Abstract: Compositions and methods are provided for inhibiting or treating the early and established stages of inflammatory diseases by administration of an effective dose of the desethylhydroxychloroquine (DHCQ). A benefit of the methods is the ability to deliver a dose of agent that is effective in treating inflammation while sparing the individual from retinal toxicity.
    Type: Grant
    Filed: March 1, 2017
    Date of Patent: April 3, 2018
    Assignees: The Board of Trustees of the Leland Stanford Junior University, The United States of America as Represented by the Department of Veterans Affairs
    Inventors: William H. Robinson, Jeremy Sokolove, Qian Wang
  • Proteins with repetitive bacterial-IG-like (Big) domains present in species
    Patent number: 9932391
    Abstract: The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the Leptospira sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and their use in diagnostic, therapeutic and vaccine applications. According to the present invention, the isolated molecules encoding for BigL1, BigL2 and BigL3 proteins are used for the diagnosis and prevention of infection with Leptospira species that are capable of producing disease in humans and other mammals, including those of veterinary importance.
    Type: Grant
    Filed: October 25, 2016
    Date of Patent: April 3, 2018
    Assignees: Cornell Research Foundation, Inc., The Regents of the University of California, The United States of America represented by the Department of Veterans Affairs, Fundaçäo Oswaldo Cruz—FIOCRUZ
    Inventors: Albert I. Ko, Mitermayer Galvão Reis, Julio Henrique Rosa Croda, Isadora Cristina Siqueira, David A. Haake, James Matsunaga, Lee W. Riley, Michele Barocchi, Tracy Ann Young
  • RUNX2 Transcription Factor Inhibitors and Uses Thereof
    Publication number: 20180086696
    Abstract: Provide herein are compounds with a general chemical structure of: Substituents R1 and R2 independently are H, Cl, F, Br, CH3, CF3, SH, —N(C1-3alkyl)2, —NHC(O)C1-3alkyl, or —NHC(O)C5-7cycloalkyl, substituent R3 is H or C1-3 alkyl and R4 is a bridged cycloalkene such as a bridged cyclohexene or a bridge-substituted cyclohexene. The compounds are therapeutics to treat a cancer, such as breast cancer, or metastatic cancers, to inhibit RUNX2 activity, such as protein expression, in a cancer cell and to increase survival of a subject with breast cancer.
    Type: Application
    Filed: September 19, 2017
    Publication date: March 29, 2018
    Applicants: University of Maryland, Baltimore, The United States of America as Represented by the Department of Veterans Affairs
    Inventors: Antonino Passaniti, MacKerell D. Alexander, JR.
  • Injectable composition for in-situ repair and regeneration of an injured ligament or tendon and methods of use
    Patent number: 9925308
    Abstract: The invention provides an injectable composition and method for the minimally invasive, in-situ repair and regeneration of an injured ligament or tendon in a mammalian subject. The composition is also useful for the delivery of growth factors, therapeutic agents and cells into the area of tendon or ligament injury.
    Type: Grant
    Filed: September 15, 2015
    Date of Patent: March 27, 2018
    Assignees: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: James Chang, Hung Pham, Colin Woon, Simon Farnebo, Anais Legrand
  • Biomarkers for Diagnosis and Prognosis of Lung Cancer
    Publication number: 20180074059
    Abstract: Provided herein are methods for non-invasively diagnosing and/or prognosing a lung cancer and for determining the efficacy of a therapeutic treatment regimen for the lung cancer. Expression levels of at least two small non-coding RNAs, for example, microRNAs and small nucleolar RNAs, are measured and used to calculate an area under the curve (AUC) that provides a probability of lung cancer in the subject. The smoking history of the subject and, if present, the size of pulmonary nodules may be incorporated into the calculation.
    Type: Application
    Filed: September 14, 2017
    Publication date: March 15, 2018
    Applicants: University of Maryland, Baltimore, The United States of America as Represented by the Department of Veterans Affairs
    Inventor: Feng Jiang
  • System and method for reconstructing cardiac activation information
    Patent number: 9913615
    Abstract: In a system and method for reconstructing cardiac activation information, an analysis cardiac signal and a reference cardiac signal are accessed and processed to determine a first point of change in the analysis cardiac signal at which a derivative of the analysis cardiac signal diverges with respect to a derivative of the reference cardiac signal. The signals are processed to determine a second point of change in the analysis cardiac signal at which a different derivative of the analysis cardiac signal with respect to a different derivative of the reference cardiac signal. An activation onset time is assigned in the analysis cardiac signal at a point based on a mathematical association among the first point of change and the second point of change to define cardiac activation indicating a beat in the analysis cardiac signal.
    Type: Grant
    Filed: November 4, 2016
    Date of Patent: March 13, 2018
    Assignees: The Regents of the University of California, Topera, Inc., The United States of America as Represented by the Department of Veterans Affairs
    Inventors: Sanjiv M. Narayan, Carey Robert Briggs, Ruchir Sehra
  • Methods and compositions for treating nephrogenic diabetes insipidus
    Patent number: 9901624
    Abstract: Disclosed are compositions and methods for treating nephrogenic diabetes insipidus and for induction of diuretic effect.
    Type: Grant
    Filed: June 16, 2014
    Date of Patent: February 27, 2018
    Assignees: The United States of America as represented by the Department of Veterans Affairs, The University of Utah
    Inventors: Bellamkonda K. Kishore, Noel G. Carlson, Donald E. Kohan, Raoul D. Nelson