Patents Assigned to The United States of America, Department of Veterans Affairs
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Patent number: 10143709Abstract: Disclosed herein is that the systemic administration of ASC conditioned media diminished LPS-induced lung injury by inhibiting epithelial permeability, neutrophil inflammatory response, and secretion of pro-inflammatory TNF?. It is also shown that ARDS lung is able to retain IV-delivered ASC for a substantial amount of time, with no evidence of the significant cell distribution to other organs at this time point. These findings provide optimization of cell-based and cell-free therapy for the treatment of ARDS, including occurrences of ARDS caused by upper respiratory tract infections such as SARS and MERS.Type: GrantFiled: May 6, 2015Date of Patent: December 4, 2018Assignees: Indiana University Research and Technology Corporation, The United States of America Department of Veteran Affairs As Represented By The Technology Transfer ProgramInventors: Keith March, Natalia Bogatcheva
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Patent number: 9464135Abstract: Methods of preventing retinal detachment associated with proliferative vitreoretinopathy are provided by administering agents which antagonize the activity or function of EMP2 to subjects at risk of the detachment.Type: GrantFiled: November 18, 2010Date of Patent: October 11, 2016Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE UNITED STATES OF AMERICA DEPARTMENT OF VETERAN AFFAIRSInventors: Lynn K. Gordon, Shawn A. Morales, David Telander, Jonathan Braun
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Publication number: 20140086886Abstract: Methods for the treatment of acute renal failure, multi-organ failure, early dysfunction of kidney transplant, chronic renal failure, organ dysfunction, and wound healing are provided. The methods include delivering a therapeutic amount of hematopoietic stem cells, non-hematopoietic, mesenchymal stem cells, hemangioblasts, and pre-differentiated cells to a patient in need thereof.Type: ApplicationFiled: September 18, 2013Publication date: March 27, 2014Applicants: United States of America Department of Veteran's Affairs, UNIVERSITY OF UTAH RESEARCH FOUNDATIONInventor: Christof Westenfelder
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Patent number: 8603462Abstract: Methods for the treatment of acute renal failure, multi-organ failure, early dysfunction of kidney transplant, chronic renal failure, organ dysfunction, and wound healing are provided. The methods include delivering a therapeutic amount of hematopoietic stem cells, non-hematopoietic, mesenchymal stem cells, hemangioblasts, and pre-differentiated cells to a patient in need thereof.Type: GrantFiled: March 31, 2004Date of Patent: December 10, 2013Assignees: University of Utah Research Foundation, United States of America Department of Veteran's Affairs.Inventor: Christof Westenfelder
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Patent number: 8461192Abstract: PKCiota inhibitor 1H-imidazole-4-carboxamide, 5-amino-1-[2,3-dihydroxy-4-[(phosphonooxy)methyl]cyclopentyl]-,[1R-(1?,2?,3?,4?)], (ICA-1), targets a unique sequence (amino acid residues 469-475) in the catalytic domain of PKCiota and inhibits PKCiota activity. The data shows suprising and unexpected ability of ICA-1 to selectively inhibit the proliferation of cells that overexpress PKCiota.Type: GrantFiled: September 15, 2008Date of Patent: June 11, 2013Assignees: The University of South Florida, The United States of America Department of Veterans Affairs, The University of Florida Research Foundation, Inc.Inventors: Mildred Acevedo-Duncan, Shraddha R. Desai, Hla Yee Win, David A. Ostrov, Prajit P. Pillai, Diondra D. Hill
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Patent number: 8361707Abstract: Methods for detecting an infection with Mycobacterium tuberculosis (Mtb) in a subject are disclosed. The methods include detecting the presence of CD8+ T cells that specifically recognize an Mtb polypeptide. The methods include in vitro assays for detecting the presence of CD8+ T cells in a biological sample, and in vivo assays that detect a delayed type hypersensitivity reaction. The methods can also include detecting Mtb polypeptides and polynucleotides. Reagents for the detection of an Mtb infection are also disclosed.Type: GrantFiled: September 23, 2011Date of Patent: January 29, 2013Assignees: Oregon Health & Science University, The United States of America, Department of Veterans AffairsInventors: David M. Lewinsohn, Deborah A. Lewinsohn
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Patent number: 8193167Abstract: Compounds and compositions are provided for treatment, prevention, or amelioration of a variety of medical disorders associated with viral infections, cell proliferation and bone metabolism. The compounds provided herein are alkyl esters of phosphonates.Type: GrantFiled: December 10, 2009Date of Patent: June 5, 2012Assignees: The Regents of the University of California, The United States of America, Department of Veterans AffairsInventors: Karl Y. Hostetler, W. Brad Wan
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Patent number: 7771956Abstract: A method, kit and probe for detecting the presence of a phospholipid, such as phosphatidylserine, in a biological material is provided. A binding agent including lactadherin, a fragment of lactadherin, a functional equivalent of lactadherin, or a functional equivalent of a fragment of lactadherin, is used to detect the presence of any phospholipid.Type: GrantFiled: June 30, 2004Date of Patent: August 10, 2010Assignees: Brigham & Women's Hospital, Inc., United States of America Department of Veterans AffairsInventors: Gary E. Gilbert, Jialan Shi, Christian W. Heegaard, Jan T. Rasmussen
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Publication number: 20090092998Abstract: The present invention relates to markers and methods for determining risk of ventricular arrhythmia in an individual. By using the markers of the present invention, individual with high risk of ventricular arrhythmia can properly be detected and treated. The present inventors have discovered that IL-6 and/or DROMs have strongly positive correlation with the risk of ventricular arrhythmia.Type: ApplicationFiled: September 10, 2008Publication date: April 9, 2009Applicant: The United States of America Department of Veterans AffairsInventor: Samuel C. Dudley, JR.
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Publication number: 20090035301Abstract: The present invention relates to the diagnosis and treatment of bladder cancer. More specifically, this invention uses the levels of macrophage migration inhibitory factor (MIF) produced by the bladder epithelia (urothelia) as a marker for bladder cancer. Moreover, the present invention also provides a method for attenuating bladder carcinoma by inhibiting of macrophage MIF.Type: ApplicationFiled: July 31, 2008Publication date: February 5, 2009Applicant: The United States of America Department of Veterans AffairsInventors: Katherine Meyer Siegler, Pedro L. Vera
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Patent number: 7485457Abstract: Human cells isolated and/or cloned from human NT2 cells for expressing serotonin (5HT) and gamma-aminobutyric acid (GABA) are disclosed. These cells can be used as cellular minipumps to release serotonin and/or GABA to treat various neurological diseases, conditions, or disorders, particularly neurodegenerative disorders and the consequences of brain and spinal cord injuries (pain/spasticity).Type: GrantFiled: July 17, 2003Date of Patent: February 3, 2009Assignees: United States of America Department of Veterans Affairs, University of MiamiInventor: Mary J. Eaton
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Patent number: 7252953Abstract: A method of detecting Alzheimer's disease includes detecting a disruption or alteration in normal sub-cellular distribution of G-protein receptor kinases (GRKs), particularly GRK2 and GRK5. The disruption is caused by abnormal accumulation of soluble ?-amyloid. The prevention or suppression of the disease progression at prodromal or early stages includes correction of GRK dysfunction.Type: GrantFiled: August 12, 2003Date of Patent: August 7, 2007Assignee: United States of America Department of Veterans AffairsInventors: Zhiming Suo, Barry W. Festoff