Abstract: A cyclized peptide designated BMP Binding Peptide (BBP) is a synthetic peptide that avidly binds rhBMP-2. BBP increases the overall osteogenic activity of rhBMP-2, increases the rate at which rhBMP-2 induces bone formation, and BBP induces calcification alone. Compositions and substrates including BBP, and methods of using BBP are useful in therapeutic, diagnostic and clinical applications requiring calcification and osteogenesis.
Type:
Grant
Filed:
April 28, 2014
Date of Patent:
May 10, 2016
Assignees:
The United States of America National Institutes of Health (NIH), U.S. Dept of Health and Human Services (DHHS), The Regents of the University of California
Inventors:
Samuel S. Murray, Elsa J. Murray, Keyvan Behnam
Abstract: Substituted 1,4,7-triazacyclononane-N,N?,N?-triacetic acid and 1,4,7,10-tetraazacyclcododecane-N,N?,N?,N??-tetraacetic acid compounds with a pendant amino or hydroxyl group, metal complexes thereof, compositions thereof, and methods of making and use in diagnostic imaging and treatment of cellular disorders.
Type:
Grant
Filed:
August 20, 2010
Date of Patent:
August 25, 2015
Assignee:
THE UNITED STATES OF AMERICA, NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS)
Abstract: Disclosed are various embodiments for echoperiodontal imaging. In one embodiment, a system includes a transducer configured to transmit a series of ultrasonic signals at a plurality of corresponding locations along soft tissue of a jaw and receive a plurality of echo signals; and an imaging system controller configured to obtain a plurality of echo signal data of the soft tissue and a plurality of transducer positions, where each echo signal data corresponds to one of the plurality of transducer position.
Type:
Grant
Filed:
July 27, 2012
Date of Patent:
May 26, 2015
Assignee:
THE UNITED STATES OF AMERICA NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), NIH DIVISION OF EXTRAMURAL INVENTIONS AND TECHNOLOGY RESOURCES (DEITR)
Inventors:
Osama M. Mukdadi, Ahmed M. Mahmoud, Eros S. Chaves, Richard Crout
Abstract: Novel thrombin/prothrombin protease/zymogen variants which have anticoagulation activity and methods of use thereof are disclosed.
Type:
Grant
Filed:
December 10, 2012
Date of Patent:
April 7, 2015
Assignee:
The United States of America National Institutes of Health (NIH), U.S. Dept. of Health and Human Services (DHHS), NIH Division of Extramural Inventions and Technology Resources (DEITR)
Inventors:
Sriram Krishnaswamy, Elsa P. Bianchini, Steven Orcutt
Abstract: A microfluidic device comprises pumps, valves, and fluid oscillation dampers. In a device employed for sorting, an entity is flowed by the pump along a flow channel through a detection region to a junction. Based upon an identity of the entity determined in the detection region, a waste or collection valve located on opposite branches of the flow channel at the junction are actuated, thereby routing the entity to either a waste pool or a collection pool. A damper structure may be located between the pump and the junction. The damper reduces the amplitude of oscillation pressure in the flow channel due to operation of the pump, thereby lessening oscillation in velocity of the entity during sorting process. The microfluidic device may be formed in a block of elastomer material, with thin membranes of the elastomer material deflectable into the flow channel to provide pump or valve functionality.
Type:
Grant
Filed:
August 21, 2007
Date of Patent:
March 31, 2015
Assignee:
The United States of America National Institute of Health (NIH), U.S. Dept. of Health and Human Services (DHHS)
Inventors:
Hou-Pu Chou, Anne Y. Fu, Stephen R. Quake
Abstract: Small molecule inhibitors of Stat3 and their derivatives are disclosed. Also described are methods to inhibit cell growth by use of Stat3 inhibitors, and the use of Stat3 inhibitors for the prevention and/or treatment of cancer. Further, inhibitors of Stat3 that also do not inhibit Stat1 are described as well as their derivatives. Methods of screening additional compounds for Stat3 inhibition activity and/or non-inhibition of Stat1 activity are also described herein.
Type:
Grant
Filed:
June 3, 2009
Date of Patent:
July 15, 2014
Assignees:
The United States of America National Institute of Health (NIH), The United States of America Dept. of Health and Human Services (DHHS)
Inventors:
David J. Tweardy, Xuejun Xu, Moses M. Kasembeli