Patents Assigned to The United States of America/NIH
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Patent number: 10196596Abstract: Disclosed herein are capillary fabrication devices comprising living cells within a support medium. Culture of the cells produces viable lumenized capillary networks with natural or pre-determined geometries and ECM and basement membrane associated with the capillary networks. The capillary networks and the ECM and basement membrane detachable from the capillary networks are useful for tissue engineering applications.Type: GrantFiled: February 22, 2016Date of Patent: February 5, 2019Assignee: National Institutes of Health (NIH), U.S. Dept. of Health and Human Services (DHHS), The United States of America NIH Division of Extramural Inventions and Technology Resources (DEITR)Inventors: James A. Glazier, Abdelkrim Alileche, Abbas Shirinifard, Dragos Amarie
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Patent number: 9770186Abstract: Methods and apparatus for operating an MRI system is provided. The disclosure provides a diffusion-prepared driven-equilibrium preparation for an imaging volume and acquiring 3-dimensional k-space data from said prepared volume by a plurality of echoplanar readouts of stimulated echoes. An excitation radio-frequency signal and first and second inversion RF signals are provided to define a field-of-view (FOV).Type: GrantFiled: February 19, 2013Date of Patent: September 26, 2017Assignee: National Institutes of Health (NIH), U.S. Dept. of Health and Human Services (DHHS), The United States of America NIH Division of Extramural Inventions and Technology Resources (DEITR)Inventors: Eun-Kee Jeong, Dennis L Parker, Kim Seong-Eun Choi, Evgueni G Kholmovski
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Patent number: 9737478Abstract: The invention contemplates compositions for the treatment of malaria comprising an anti-malaria drug and an adjuvant which promotes vasodilation and methods of using same.Type: GrantFiled: September 13, 2010Date of Patent: August 22, 2017Assignee: National Institutes of Health (NIH), U.S. Dept. of Health and Human Services (DHHS), The United States of America NIH Division of Extramural Inventions and Technology Resources (DEITR)Inventors: Leonardo Jose de Moura Carvalho, Pedro Cabrales
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Patent number: 9649343Abstract: The present invention provides compositions that include an extract of human feces, and methods for using such compositions, including methods for replacing or supplementing or modifying a subject's colon microbiota, and methods for treating a disease, pathological condition, and/or iatrogenic condition of the colon.Type: GrantFiled: September 9, 2016Date of Patent: May 16, 2017Assignee: National Institutes of Health (NIH); U.S. Department of Health and Human Services (DHHS); The United States of America, NIH Division of Extramural Inventions and Tehnology Resources (DEITR)Inventors: Michael J. Sadowsky, Alexander Khoruts, Alexa R. Weingarden, Matthew J. Hamilton
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Patent number: 9594141Abstract: An MR imaging system uses multiple RF coils for acquiring corresponding multiple image data sets of a slice or volume of patient anatomy. An image data processor comprises at least one processing device conditioned for, deriving a first set of weights for weighted combination of k-space data of the multiple image data sets for generating a calibration data set comprising a subset of k-space data of composite image data representing the multiple image data sets. The image data processor uses the calibration data set in generating a first MR image data set, deriving the parameters of a probability distribution in response to the first set of weights and the first MR image data set and deriving a second set of weights and second MR image data set together using the probability distribution.Type: GrantFiled: October 3, 2012Date of Patent: March 14, 2017Assignees: National Institutes of Health (NIH), U.S. Dept. of Health and Human Services (DHHS), The United States of America NIH Division of Extramural Inventions and Technology Resources (DEITR), The General Hospital Corporation, Siemens Healthcare GmbHInventors: Daniel Weller, Leo Grady, Lawrence Wald, Vivek K Goyal
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Patent number: 9588207Abstract: A system for parallel image processing in MR imaging comprises multiple MR imaging RF coils for individually receiving MR imaging data representing a slice of patient anatomy. An MR imaging system uses the multiple RF coils for acquiring corresponding multiple image data sets of the slice. An image data processor comprises at least one processing device conditioned for, deriving a first set of weights for generating a calibration data set comprising a subset of k-space data of composite image data representing the multiple image data sets. The at least one processing device uses the calibration data set in generating a first MR image data set, deriving a second set of weights using the calibration data set and the generated first MR image data set and uses the second set of weights in generating a second MR image data set representing a single image having a reduced set of data components relative to the first composite MR image data set.Type: GrantFiled: September 14, 2012Date of Patent: March 7, 2017Assignees: National Institutes of Health (NIH), U.S. Dept. of Health and Human Services (DHHS), The United States of America NIH Division of Extramural Inventions and Technology Resources (DEITR), Siemens Healthcare GmbHInventors: Daniel Weller, Leo Grady, Lawrence Wald, Vivek K Goyal
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Patent number: 9220706Abstract: A method of inhibiting the growth of leukemic hematopoietic stem cells in a subject with leukemia is described. The method includes administering a therapeutically effective amount of a composition including a compound of formula I: I wherein R1 is independently selected from hydrogen and methyl; R2 is selected from the group consisting of 4,8-dimethyl-non-1-enyl, 4,8-dimethyl-nonyl, non-1-enyl, and nonanyl groups; X is a carboxyl, phosphonic, or sulfonic moiety, and n is an integer from 1 to 6, or a compound of Formula II: II wherein R1 is a C6-C12 alkyl or C6-C12 alkoxy group; R2 is independently selected from the group consisting of hydrogen, methoxy, and hydroxyl; and R3 is an alkyl or cycloalkyl group; or a pharmaceutically acceptable salt thereof.Type: GrantFiled: May 31, 2013Date of Patent: December 29, 2015Assignees: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), THE UNITED STATES OF AMERICA NIH DIVISION OF EXTRAMURAL INVENTIONS AND TECHNOLOGY RESOURCES (DEITR)Inventors: Danilo Perrotti, Paolo Neviani
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Patent number: 8779312Abstract: The present disclosure provides methods, devices and kits that permit large numbers of target biomolecules to be detected simultaneously in samples originating from a multi-sample holder, such as a multi-well plate. One specific example method is a method of making multiple substantial replicas of a biomolecular content of a multi-well sample holder. Devices and kits for carrying out the described methods are also provided.Type: GrantFiled: November 25, 2009Date of Patent: July 15, 2014Assignees: United States of America/NIH, 20/20 Genesystems, Inc.Inventors: Vladimir Knezevic, Dan-Paul Hartmann, Michael R. Emmert-Buck
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Patent number: 7842786Abstract: The present invention provides isolated nucleic acid and amino acid sequences of sweet or amino acid taste receptors comprising T1R3 and T1R1, two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.Type: GrantFiled: May 15, 2008Date of Patent: November 30, 2010Assignees: Regents of the University of California, United States of America, NIHInventors: Charles S Zuker, Nicholas J. P. Ryba, Jayaram Chandrashekar, Mark A Hoon, Yifeng Zhang, Gregory A Nelson
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Patent number: 7838222Abstract: The present disclosure provides methods, devices and kits that permit large numbers of target biomolecules to be detected simultaneously in samples originating from a multi-sample holder, such as a multi-well plate. One specific example method is a method of making multiple substantial replicas of a biomolecular content of a multi-well sample holder. Devices and kits for carrying out the described methods are also provided.Type: GrantFiled: March 22, 2006Date of Patent: November 23, 2010Assignees: United States of America/ NIH, 20/20 Genesystems, Inc.Inventors: Vladimir Knezevic, Dan-Paul Hartmann, Michael R. Emmert-Buck
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Patent number: 7807174Abstract: The present invention provides new compositions and methods for preventing and treating pathogen infection. In particular, the present invention provides compounds having an anchoring domain that anchors the compound to the surface of a target cell, and a therapeutic domain that can act extracellularly to prevent infection of a target cell by a pathogen, such as a virus. The present invention also comprises therapeutic compositions having sialidase activity, including protein-based compounds having sialidase catalytic domains. Compounds of the invention can be used for treating or preventing pathogen infection, and for treating and reducing allergic and inflammatory responses. The invention also provides compositions and methods for enhancing transduction of target cells by recombinant viruses. Such compositions and methods can be used in gene therapy.Type: GrantFiled: September 10, 2004Date of Patent: October 5, 2010Assignees: NexBio, Inc., The United States of America/NIHInventors: Fang Fang, Michael Malakhov