Patents Assigned to The United States of America, per Secy. DHHS, NIH
  • Sigma-2 receptor agonists and their use in the treatment of HIV infection
    Publication number: 20060004036
    Abstract: The present invention relates to sigma-2 receptor agonists and their use in the treatment of immunodeficiency virus infections, especially human immunodeficiency virus (HIV) infections. The invention particularly relates to sigma-2 agonists, especially CB-184 and its analogues, that decrease cellular production of sphingomyelin when provided to recipient cells, and inhibit HIV replication.
    Type: Application
    Filed: July 15, 2005
    Publication date: January 5, 2006
    Applicant: The United States of America, per Secy. DHHS, NIH
    Inventors: Wayne Bowen, Keith Crawford, James Hildreth