Patents Assigned to THE UNITED STATES OF AMERICA, REPRESENTED BY, DEPA RTMENT OF HEALTH
  • MODIFIED GROWTH HORMONE
    Publication number: 20110135614
    Abstract: The invention provides, a nucleic acid molecule encoding a growth hormone (GH) in which the RSP sorting signal has been mutated, such that the GH can be constitutively secreted by the nonregulated secretory pathway (NRSP) in a mammalian cell. The invention also provides a nucleic acid molecule encoding a GH in which the three-dimensional conformation of the RSP sorting signal has been altered such that the GH can be constitutively secreted by the NRSP in a mammalian cell.
    Type: Application
    Filed: January 19, 2011
    Publication date: June 9, 2011
    Applicant: THE UNITED STATES OF AMERICA, REPRESENTED BY, DEPA RTMENT OF HEALTH
    Inventors: Yoke Peng Loh, Niamh Cawley, Bruce J. Baum, Christopher R. Snell