Abstract: An argon fluoride (ArF) laser system for inertial nuclear fusion energy production with lower required laser energy than other laser drivers. An Argon fluoride laser system uniformly illuminates a spherical capsule comprising an outer ablator wall surrounding an inner shell comprising the fusion fuel. The laser beams are adjusted spectrally to achieve a bandwidth of up to 12 THz and a coherence time as low as 80 femtoseconds that in combination with the short wavelength (193 nm) suppress laser plasma instabilities. Uniform spherical acceleration causes the inner shell of the target capsule to form a spherical assembly of compressed fuel surrounding a “hot spot” that has sufficient temperature, density and size to ignite and initiate a thermonuclear burn.

Abstract: A smart part comprising: a body, manufactured by a three-dimensional (3D) additive manufacturing (AM) process, having high-stress and low-stress sections, wherein when the smart part is in operational use the high-stress section is subjected to higher stress than the low-stress section; and wherein the body comprises a void having a predefined geometry intentionally created within the high-stress section of the body during the AM process, such that the void is completely embedded within the body and is configured to provide quality assurance information.

Abstract: Disclosed herein are bisarylmethylthioacetamides and bisarylmethylthioethylamines useful as inhibitors of monoamine transporters. The compounds are potent and/or selective inhibitors of dopamine (DA), serotonin (5-HT), and/or norepinephrine (NE) reuptake via their respective transporters, DAT, SERT and NET. Also disclosed are methods for eliciting a wake-promoting or cognitive or attention enhancing effect and for treating substance use disorders, attention deficit (hyperactivity) disorder, depressive disorders, bipolar disorder or other neuropsychiatric disorders sleep disorders or cognitive impairment using the compounds.

Abstract: Methods to convert an oxygen containing organic compound(s) to one or more water-free liquid hydrocarbons products. They make use of a catalytic process in a two-stage reactor system having a first reactor and a second reactor in series. Process design is described for effective conversion of aqueous low energy-dense aqueous solutions containing oxygen containing organic compound(s) to liquid hydrocarbons; the process design preferably employs the solid acid catalysts comprised of microporous aluminosilicates denoted as zeolites mixed with silicon carbide binder in series of two reactor system with capability of complete water removal.

Abstract: A payload release mechanism is provided, which operates utilizing a pressure differential between the mechanism and the surrounding medium. A piston is movably seated within a chamber of the release mechanism. The piston serves to seal the chamber from the surrounding medium, though one end of the piston is in communication with the surrounding medium. The pressure differential between the end of the piston in communication with the surrounding medium and the medium within the chamber causes the piston to move. The piston movement is used to trigger the release of the payload. The amount of movement which triggers the release can be calibrated to correspond to a predetermined pressure differential.

Abstract: This invention describes resins with phosphate cores and a simple, three-step process for their synthesis. Preferred resins are cyanate ester resins with bridging phosphate groups. These resins can be cured to produce thermoset polymers having Tgs of between 131 and >360° C. depending on the number of cyanate ester groups per phosphate and the substitution pattern of the aromatic rings. The high char yields of these resins, up to about 67%, coupled with the phosphate core means that these materials will have applications as fire-resistant polymers. Additionally, these materials can potentially be blended with conventional cyanate esters or other compatible thermosetting resins to improve the fire resistance of composite materials. Other applications may include use in fire-resistant circuit boards, or as surface coatings to reduce flammability of conventional composite materials or thermoplastics.

Abstract: A blast containment system for trash cans includes a donut-shaped bag having a sealed donut-shaped bottom positioned at the base of the trash can, and an open donut-shaped top positioned and retained at a top periphery of the trash can. An open-ended tubular region extends through the bag between its donut-shaped top and donut-shaped bottom. A rigid container having an open top is disposed in the tubular region of the bag with its open top being coupled to the donut-shaped top of the bag. A liquid fills the bag.

Abstract: An x-ray spectrometer includes: an x-ray plasma source that produces first x-rays; an x-ray optic in optical communication with the x-ray plasma source and that: receives the first x-rays from the x-ray plasma source; focuses the first x-rays to produce second x-rays; and communicates the second x-rays to a sample that produces product x-rays in response to receipt of the second x-rays and second light; and a microcalorimeter array detector in optical communication with the sample and that receives the product x-rays from the sample.

Abstract: Object/facial recognition systems, methods, architectures, mechanisms and/or apparatus for 3D face or object recognition using a 3D surface reconstructed from polarimetric thermal facial/object imager to form a 2D or 3D image which is rotated to conform with a pose of a reference image to allow comparison thereto.

Abstract: A system includes a control station that enables efficient human collaboration with automated object tracking. The control station is communicatively coupled to an aerial vehicle to receive full motion video of a ground scene taken by an airborne sensor of the aerial vehicle. The control station spatially registers features of a movable object present in the ground scene and determines motion of the movable object relative to the ground scene. The control station predicts a trajectory of the movable objective relative to the ground scene. The control station tracks the movable object based on data fusion of: (i) the spatially registered features; (ii) the determined motion; and (iii) the predicted trajectory of the movable object. The control station presents a tracking annotation and a determined confidence indicator for the tracking annotation on a user interface device to facilitate human collaboration with object tracking.

Abstract: Disclosed is a T cell receptor (TCR) having antigenic specificity for an HLA-A2-restricted epitope of human papillomavirus (HPV) 16 E6, E629-38. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells are also provided. Antibodies, or an antigen binding portion thereof, and pharmaceutical compositions relating to the TCRs of the invention are also provided. Also disclosed are methods of detecting the presence of a condition in a mammal and methods of treating or preventing a condition in a mammal, wherein the condition is cancer, HPV 16 infection, or HPV-positive premalignancy.

Abstract: An optical system has a beam-steering device, a light source, and a controller that controls the light source to actively control wavelength of the incoming light to control the output angle of the outgoing light output from the BS device. The BS device may have incoupler, waveguide, and/or outcoupler electrodes, and the system may have corresponding controllable voltage supplies actively controlled by the controller to selectively modify electric fields applied to the BS device to control corresponding operating characteristics of the BS device (e.g., in-plane and/or out-of-plane output angles of the outgoing light and/or device incoupling angle). An alternative optical system has a BS device, a detector array that generates detector signals corresponding to outgoing light received from the BS device, and a controller that processes the detector signals to determine one or more wavelengths of the outgoing light.

Abstract: Backfunctionalized imidazolinium salts and methods of synthesizing the same and NHC carbene-metal complexes therefrom. For backfunctionalized imidazolinium salts of the formula: Wherein R1 is selected from the group consisting of an ester group, an amide group, and an aromatic group; R2 is selected from the group consisting of hydrogen, an ester group, an amide group, and an aromatic group; R3 and R4 are each an aliphatic group; and X is an anion; the method comprises cyclization of a halogenated acrylate with Hünig's base in a solvent.

Abstract: Disclosed is a salt prepared from the STAT3 inhibitor known as 2-hydroxy-4-[[2-[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino] benzoic acid and 2-amino-2-(hydroxymethyl)-1,3-propanediol. The salt is soluble in water and stable for extended periods of time. Further provided are pharmaceutical compositions comprising the salt and methods of administering the salt to prevent and treat cancer, such as breast cancer.

Abstract: Various embodiments related to systems and methods for instant structured microscopy where total internal reflection fluorescence techniques are used to improve optical sectioning and signal-to-noise ratio of structured illumination microscopy are herein disclosed.

Abstract: Genetically modified compositions, such as non-viral vectors and tumor infiltrating lymphocytes, for the treatment of gastrointestinal cancer are disclosed. Disclosed are methods of utilizing a CRISPR system to generate genetically modified compositions. Also disclosed are the methods of making and using the genetically modified compositions for the treatment of gastrointestinal cancer.

Abstract: The present disclosure provides methods for inhibiting and/or reducing self-reactive IgE and/or basophils, thereby treating or preventing lupus, lupus nephritis, and lupus-related disorders.

Abstract: The description provides novel compounds that may serve as anticancer therapeutics. The compounds of the description bind to polo-like kinases through the polo-box domain. The peptide derivatives of the description have achieved improved efficacy in biochemical assays against Plk1. Exemplary compounds of the description include macrocyclic peptidomimetics with high affinity and selectivity for polo-like kinases, which may provide the basis for a new genre of anticancer therapeutics. Other exemplary compounds of the description include bi-valent compounds with that bind to polo-like kinases through both kinase domain and polo-box domain simultaneously by incorporating additional moieties that target Plk1 kinase domain, which significantly enhances affinitity relative and may provide the basis for a new genre of anticancer therapeutics. The description also provides methods of use, methods of preparation, compositions, and kits thereof.

Abstract: The System for Continuous Observation of Rodents in Home-cage Environment (SCORHE) was developed to quantify activity levels and behavior patterns for mice housed within a home cage that, optional, may be disposed in a commercial ventilated cage rack. The SCORHE home-cage in-rack design provides daytime and night-time monitoring with the stability and consistency of the home-cage environment. The dual-video camera custom hardware design makes efficient use of space, does not require home-cage modification, and is animal facility user-friendly. In various embodiments, a software application integrates the two video streams to extract several mouse activity measures.

Abstract: A new and distinct hybrid Tsuga cultivar tree named ‘Traveler’ is disclosed, characterized by a slightly weeping and graceful pyramidal habit, tolerance to hemlock woolly adelgid, and moderately slow growth rate. ‘Traveler’ is well-suited for use as a landscape tree in a large yard or park. It transplants well from containers.