Patents Assigned to The United States of America
  • Patent number: 5991021
    Abstract: The purpose of the nonlinear spectrophotometer is to provide a simple instrument that can be used on a routine basis to accurately measure the two-photon absorption (TPA) coefficient and cross-section on a wide variety of materials. The instrument is capable of measuring: (1) both organic and inorganic materials, (2) solutions and thin film materials forms, and (3) materials which are fluorescent and nonfluorescent.
    Type: Grant
    Filed: February 1, 1999
    Date of Patent: November 23, 1999
    Assignee: The United States of America as represented by the Secretary of the Air Force
    Inventors: Anadi Mukherjee, Nandini Mukherjee, Conrad S. Sarvis, Bruce A. Reinhardt
  • Patent number: 5991036
    Abstract: A two-dimensional imager for measuring the electric-field amplitude and phase distribution across an extended spatial region for millimeter and microwave electro-magnetic waves. The imager consists of a small active area within a generally passive structure which measures the electric (E)-field amplitude and phase information and impresses this information onto an optical beam. The E-field information is measured by converting the optical signal into and electrical signal and demodulating the E-field information from the electrical signal by processing electronics where the electrical signal is conditioned, stored and the data displayed.
    Type: Grant
    Filed: September 30, 1997
    Date of Patent: November 23, 1999
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventor: Michael Y. Frankel
  • Patent number: 5991714
    Abstract: A method of identifying the types of data contained in an electronic file of unknown data type by gathering exemplary files of each data type of interest; counting the number of unique n-grams within each exemplary file; determining a weight for each unique n-gram; listing the unique n-grams in the exemplary files of a particular data type by descending magnitude of weight for each data type of interest; selecting the top m weighted n-grams and their associated weights; establishing a threshold for each data type of interest; selecting a length of data from the electronic file; listing every n-gram in the data selected; giving each listed n-gram, that was also selected, the weight that that n-gram was given for each data type of interest; summing the weights given to each n-gram according to data type; comparing the sums to the thresholds established in order to determine the types, if any, of the selected data; recording the location of the selected data if it is of a data type of interest; stopping if the n
    Type: Grant
    Filed: April 22, 1998
    Date of Patent: November 23, 1999
    Assignee: The United States of America as represented by the National Security Agency
    Inventor: Richard Allen Shaner
  • Patent number: 5991537
    Abstract: A system is provided for developing program test sets with test hardware conforming to well known test industry standards, such as VXI, VME and GPIB standards. The system has a computer with a display console. After initialization and password checks, the console displays a front panel from which a user chooses the instruments, switches, connections, inputs, outputs, etc. which make up the program test set. As each choice is made, the system generates test script corresponding to the choice. The system then uses the test script, or macro, to generate the graphical representation of the component and its connections on the display. The graphical displays are standardized for each functional component or operation of a program test set, as well as being standardized between program test sets. The macros further allow a program test set to be more efficiently developed by coding macros rather than by developing graphical displays.
    Type: Grant
    Filed: September 16, 1997
    Date of Patent: November 23, 1999
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Brian T. McKeon, Mark C. Larson, Douglas H. Sherman
  • Patent number: 5989494
    Abstract: A tungsten heavy alloy composition comprising tungsten, iron and elements selected from the groups X, Y and Z and having the formula W.sub.100-p Fe.sub.i X.sub.j Y.sub.k Z.sub.l. Such that "X" is one or more elements selected from the group consisting of Ni, Mn and Co; "Y" is one or more elements selected from the group consisting of Cr, Mo and V; "Z" is one or more elements selected from the group consisting of C, Si, Ti and Al; "i" ranges from 5 to 19.5 weight percent; "j" ranges from 0.05 to 6 weight percent; "k" ranges from 0.15 to 5 weight percent; "l" ranges from 0.05 to 4 weight percent; and "p" is the mathematical sum of i, j, k and l, and ranges from 7 to 20 such that "100-p" ranges from 93 to 80 weight percent. The blended powder mixture thus formed is hot consolidated to full density. The hot consolidated blended powder mixture is subjected to a hardening heat treatment.
    Type: Grant
    Filed: March 18, 1998
    Date of Patent: November 23, 1999
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventor: Deepak Kapoor
  • Patent number: 5991000
    Abstract: A method for forming a uniform cavity between electrode substrates of a dlay comprises the steps of patterning a border to define a display area between the electrode substrates, patterning electrode spacers between the electrode substrates, and wafer bonding the electrode substrates to the border and to the electrode spacers to form a uniform cavity within the display area. A cavity comprises a pair of substrates enclosing the cavity and patterned spacers wafer bonded to the substrates to form and maintain a uniform thickness of the cavity.
    Type: Grant
    Filed: June 13, 1996
    Date of Patent: November 23, 1999
    Assignee: United States of America as represented by the Secretary of the Navy
    Inventors: Randy L. Shimabukuro, Howard Walker, Stephen D. Russell
  • Patent number: 5989521
    Abstract: The present invention relates, in general, to a method for augmenting reduced glutathione level in the lungs of patients. In particular, the present invention relates to a method for augmenting reduced glutathione level in the lungs of patients with cystic fibrosis (CF), acquired immunodeficiency syndrome (AIDS), or idiopathic pulmonary fibrosis (IPF).
    Type: Grant
    Filed: December 31, 1991
    Date of Patent: November 23, 1999
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventor: Ronald G. Crystal
  • Patent number: 5988875
    Abstract: A method of simultaneously measuring thermal conductivity and heat capacity of a fluid, using a heat conduction calorimeter having a reference fluid in a first cell and a sample fluid in a second cell includes the steps of calibrating the calorimeter using a standard fluid having known thermal conductivity and heat capacity over a range of temperatures and the reference fluid to determine a set of sensitivity parameters, {a.sub.n.sup.ij }, of the calorimeter, wherein the a.sub.n.sup.ij are functions of the calorimeter, temperature and the reference fluid; applying a square wave heat pulse to the calorimeter containing said sample fluid and said reference fluid; measuring the thermal response curve to the square wave heat pulse, wherein the thermal response curve is a function of time, temperature of the measurement, thermal properties of the sample fluid, and thermal properties of the reference fluid; reducing the response curve to a set of discrete characteristic parameters, {p.sub.
    Type: Grant
    Filed: December 19, 1997
    Date of Patent: November 23, 1999
    Assignee: The United States of America as respresented by the Department of Health and Human Services
    Inventors: Norman Gershfeld, Courtney Mudd, Albert Jin, Kazuhiro Fukada
  • Patent number: 5990829
    Abstract: A computer vision system is disclosed that utilizes a spinning array of podetectors. The array is rotated about the focal plane of a lens and scans all the possible orientations and positions of the edges of the unknown object. In one embodiment, the photodetectors are elongated so as to provide for maximum light gathering ability along the direction of elongation and a minimum light gathering ability in the direction perpendicular to the direction of elongation. In other embodiments, optical means are used to focus the image onto conventional photodetectors while still having the ability to more efficiently determine edge segments of unknown objects. The system efficiently and rapidly implements the wavelet projection transform to characterize-multi-scale edge segment features of an image of an unknown object. An imaging radar system that utilizes a spinning antenna system having frequency scanning provisions is also disclosed.
    Type: Grant
    Filed: July 3, 1998
    Date of Patent: November 23, 1999
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventor: Joseph P. Garcia
  • Patent number: 5990088
    Abstract: The present invention relates to a method to treat Kaposi's sarcoma (KS), and particularly, human immunodeficiency virus associated KS through the administration of antisense oligonucleotides complementary to basic fibroblast growth factor RNA.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: November 23, 1999
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Barbara Ensoli, Robert C. Gallo
  • Patent number: 5989748
    Abstract: The power loss of lithium/lithium ion battery cells is significantly reduced, especially at low temperatures, when about 1% by weight of an additive is incorporated in the electrolyte layer of the cells. The usable additives are organic solvent soluble cyanoethylated polysaccharides and poly(vinyl alcohol). The power loss decrease results primarily from the decrease in the charge transfer resistance at the interface between the electrolyte and the cathode.
    Type: Grant
    Filed: May 8, 1998
    Date of Patent: November 23, 1999
    Assignee: The United States of America as represented by the United States Department of Energy
    Inventor: Ganesan Nagasubramanian
  • Patent number: 5989551
    Abstract: The method and compositions of this invention provide an effective and reliable substitute for the currently employed ICA assay for diabetes. By providing a method for detecting autoantibodies to GAD.sub.65, IA-2 and a previously unidentified antigen termed IA-2.beta. herein, the method provides a chemical assay which has improved reliability. In addition, these antigens may be employed in therapeutic regimens aimed at achieving amelioration of the clinical condition.
    Type: Grant
    Filed: October 25, 1995
    Date of Patent: November 23, 1999
    Assignees: The United States of America as represented by the Department of Health and Human Services, The University of Florida
    Inventors: Noel K. Maclaren, Abner L. Notkins, Michael S. Lan, Qing Li
  • Patent number: 5991829
    Abstract: An SCSI controller adapted as a network file server provides a virtual coction between a plurality of host processors and a single SCSI initiator. The controller contains a removable host adapter for connection to any type of network interface. When a host processor issues a command packet and requests status information of a target device, that status information is passed to the requesting processor and subsequently stored in the controller and made available to all other host processors on the network. A fault tolerant performance monitoring algorithm, executing within the controller, is scheduled to non-intrusively and periodically check the status of each SCSI target device and to store that status information for all host processors.
    Type: Grant
    Filed: March 29, 1994
    Date of Patent: November 23, 1999
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Paul J. Giorgio, Stephen J. Amuro
  • Patent number: 5990774
    Abstract: The invention is a magic sphere having an equatorial gap, with a radial metic field in the equatorial gap. The radial magnetic field can flow inward, toward the center of the magic sphere, or outward, away from the magic sphere. In a further embodiment, the magic sphere produces a periodically radial magnetic field. In another embodiment, a magic sphere with an azimuthally periodic radial magnetic field that flows in the outward direction periodically magnetizes a magnetically hard ring in the outward direction. Then, a magic sphere with an azimuthally periodic radial magnetic field that flows inwardly, periodically magnetizes the ring in the inward direction. The result is a permanent magnet that has a radial magnetic field, where the direction of the field periodically alternates from the inward to the outward direction.
    Type: Grant
    Filed: November 5, 1998
    Date of Patent: November 23, 1999
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventor: Herbert A. Leupold
  • Patent number: 5990551
    Abstract: A module and a method of making the module is disclosed. The module is fod from a semiconductor and a silicon carbide chip for high temperature applications. The module is designed to be compatible with current silicon IC processes.
    Type: Grant
    Filed: March 23, 1998
    Date of Patent: November 23, 1999
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Timothy Mermagen, Judith McCullen, Robert Reams, Bohdan Dobriansky
  • Patent number: 5989546
    Abstract: A method for the treatment or prevention of allergic disorders is provided, comprising inducing the death by apoptosis of a subpopulation of T lymphocytes that is capable of causing such diseases, while leaving substantially unaffected the majority of other T lymphocytes. Cell death is achieved by cycle(s) comprising challenging via immunization these T cells with antigenic substance at short time intervals, or by immunization followed by administering interleukin-2 (IL-2) when these T cells are expressing high levels of IL-2 receptor so as to cause these T cells to undergo apoptosis upon re-immunization with the antigenic peptide or protein. These methods are applicable to the treatment of allergic disorders such as hay fever, extrinsic asthma, or insect bite and sting allergies, and food and drug allergies.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 23, 1999
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventor: Michael J. Lenardo
  • Patent number: 5990296
    Abstract: This invention provides for recombinant single chain antibodies capable of specifically binding to a Lewis.sup.Y -related carbohydrate antigen and fusion proteins comprising these antibodies. More particularly, the invention provides for single chain Fv regions of the monoclonal antibody B3. The invention also provides for a method of improving the binding affinity of antibodies lacking a serine at position 95 of the V.sub.H region that involves mutating position 95 to a serine.
    Type: Grant
    Filed: December 3, 1996
    Date of Patent: November 23, 1999
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Ira Pastan, Mark Willingham, David Fitzgerald, Ulrich Brinkmann, Lee Pai
  • Patent number: 5989397
    Abstract: Process control for generating graded multilayer films repetitively and consistently using both pulsed laser sputtering and magnetron sputtering deposition techniques. The invention includes an apparatus which allows for set up of an ultrahigh vacuum in a vacuum chamber automatically, and then execution of a computer algorithm or "recipe" to generate desired films. Software operates and controls the apparatus and executes commands which control digital and analog signals which control instruments.
    Type: Grant
    Filed: October 30, 1997
    Date of Patent: November 23, 1999
    Assignee: The United States of America as represented by the Secretary of the Air Force
    Inventors: Samuel J. P. Laube, Andrey A. Voevodin, Jeffrey S. Zabinski, Steven R. LeClair
  • Patent number: 5989540
    Abstract: Described herein are constructions of recombinant DNA comprising modified adeno-associated virus (AAV) DNA sequences capable of functioning as a eukaryotic expression vector for expressing foreign DNA sequences using a novel transcription promoter comprising the termini of AAV DNA. It is shown that expression of a test reporter gene can be obtained from this vector in mammalian cells. It is further shown that this combination of vector and promoter can be used to introduce and express a human gene and correct a genetic defect in human cells resulting from malfunction of the mutant endogenous gene. Further, the vector can be used to correct the genetic defect by expressing a modified version of the human gene consisting of a fusion of part of the said gene and a synthetic sequence contained in the vector.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: November 23, 1999
    Assignee: The United States of America as represented by the Department of Health & Human Services
    Inventors: Barrie J. Carter, Terence Flotte, Sandra Afione, Rikki Solow
  • Patent number: 5987962
    Abstract: A copper crusher gauge holder for testing internal pressures of cartridges uring test firing is provided. The copper crusher gauge holder has a circular aluminum upper plate and a circular aluminum lower plate having a layer of urethane rubber approximately 3/4 inch thick sandwiched between the plates. The gauge holder is bored to hold copper crusher gauges and center-bored to fit over a cartridge centerline primer tube. A series of machine screws hold the plates together and allow for tightening the screws once the copper crusher gauge holder is in place in a cartridge to be tested. As the machine screws are tightened, the urethane rubber expands laterally gripping the inside of the cartridge and gripping the copper crusher gauges. A method to manufacture the gauge holder is provided.
    Type: Grant
    Filed: September 15, 1997
    Date of Patent: November 23, 1999
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Eugene W. Bowie, Raymond E. Bowen