Abstract: A system and related methods that generate encryption keys using two inputs. The first input is random data measured or supplied at the time the encryption keys are created. The second input is predetermined data held by the server and device. Given knowledge of the predetermined data and the random data, the UxS will be able to regenerate its previous encryption keys and also to re-establish communication by the server and device.

Abstract: The invention is directed to methods of treating or preventing a Rhabdoviridae virus infection in a mammal comprising administering griffithsin, or a fragment or mutant thereof, to the mammal.

Abstract: Provided is a method of treating cancer, particularly cancers associated with an overexpression of polo-like kinase (Plk1), comprising administering a compound of formula (I) or a pharmaceutically acceptable salt thereof in which ring A, X1, X2, X3, X4, X5, R2, R3, R4, n, bond a, and bond b are described herein. Exemplary compounds of formula (I) and pharmaceutically acceptable salts thereof, especially those that selectively inhibit the polo box domain of Plk1, also are provided.

Abstract: Provided is a broadband multi-line laser beam combiner apparatus and method that allows a broader spectrum of light to be emitted from a single optical path. The disclosed apparatus and method provide the ability to combine a number of unique laser lines including both visual and infrared light as one optical beam that is emitted from a single emission aperture or window using both conventional dichroic mirrors and an imaging dichroic mirror. The apparatus and method are based, in part, on an optical material selection and design that affords the ability to combine multiple broadband laser sources. Rather than merely emitting discrete laser lines, the presently disclosed broadband multi-line laser beam combiner can emit an “ultra-wide-continuum” of wavelengths from approximately 400 nm to 5000 nm at emitted optical powers greater than five (5) Watts from one emission aperture/window.

Abstract: The present invention relates to methods and processes to prepare pre-mixed compositions that can be combined to form pyrotechnic compositions in mixed multiple parts. In exemplary embodiments, a binder curing agent ingredient is premixed with pyrotechnic fuels and can also include other pyrotechnic additives and processing aides. Other binder ingredients such as a binder resin can be premixed with the pyrotechnic oxidizers and can also include other pyrotechnic additives and processing aides. The resulting mixtures are not explosive and are much safer to handle and easier to store for extended shelf-life over a final pyrotechnic composition. Further, the pre-mixed mixtures can be stored in bulk until needed and rapidly combined to achieve the final pyrotechnic composition.

Abstract: An apparatus verifies hosted information associated with a user. The apparatus establishes, by the online host serving as a relying party system (RPS), a secure connection between the RPS and a user mobile-identification-credential device (UMD). The RPS sends a mobile identification credential (MIC) user information request to the UMD, via the secure connection, seeking release of MIC user information (official information). The RPS obtains from authorizing party system (APS) verification of the MIC user information received in response to the MIC user information request. The RPS stores the MIC user information as hosted information pertaining to the user. The RPS designates the hosted information as base truth information representing the user.

Abstract: Scalable power processing units (PPUs) for Hall-effect thrusters (HETs) and terrestrial systems are disclosed. A technique for current estimation may be employed on each output of parallel isolated discharge supply modules (DSMs) to force proper current/load sharing between the DSMs. A flyback power supply may be used that performs the dual functions of a cathode keeper plasma ignitor and sustainer. The flyback power supply may be tuned for a high no-load direct current (DC) output voltage to achieve cathode keeper ignition rather than requiring a separate ignitor supply, which reduces circuit complexity. To address requirements for higher voltage DC ignition than are achievable with a flyback power supply alone, a supplemental DC ignitor may be placed in parallel with the flyback power supply of some embodiments. Such simplified PPU architectures may provide a high efficiency, low part count, scalable architecture suitable for more compact and lower cost system designs.

Abstract: The present disclosure is directed to antibodies binding to Glypican 2 and methods of using such antibodies to treat cancers that express or overexpress the Glypican 2 antigen.

Abstract: An electrically conductive, flexible, strain resilient product is produced by mixing metal coated carbon nanotube networks with a liquid polymeric resin to produce a liquid mixture, and the mixture is cured to produce the product. The networks may include welded junctions between nanotubes formed by depositing and melting metal nanoparticles on the nanotubes to form the metal coating. After the mixing step the liquid mixture may be deposited on a flexible substrate in the form of an electrical circuit. The mixing step may further include mixing the composite with a volatile solvent to produce a selected viscosity. Then, a three-dimensional printer may be used to print the product, such as an electrical circuit, on a substrate. The product is cured in an atmosphere that absorbs the solvent. The conductivity of the mixture may be adjusted by adjusting the weight percentage of the metal coated carbon nanotube networks from 50% to 90%, but a preferred range is between 75% and 85%.

Abstract: The invention is directed to a more efficient lentiviral vector comprising a nucleic acid sequence encoding a human ?-globin protein or a human ?-globin protein, which is oriented from 5? to 3? relative to the lentiviral genome. The invention also provides a composition and method utilizing the lentiviral vector.

Abstract: Systems and methods are provided for color-enhancing satellite data in a manner that is specific to the true color ocean signal, i.e., the light that is emanating from the ocean surface. These color enhanced images, in turn, can be used as a scientific research and monitoring tool for studying the coastal ocean.

Abstract: Systems and methods are provided herein that implement and utilize temporal state machines and other temporal computational/memory circuits. For example, a temporal state machine is provided that comprises a temporal computational unit comprising at least one circuit to perform a time-domain operation, and a temporal memory unit. Both the temporal computational unit and temporal memory unit can operate using solely, or partially, time-encoded wavefronts. The computation unit accesses time-encoded wavefronts from the memory and can output and write time-encoded wavefronts back to the memory.

Abstract: The present disclosure includes a system and method for monitoring degradation of a high temperature composite component (HTC). The HTC is defined by a volume that includes a matrix material and a fiber formed from at least one of ceramic and carbon material. One or more electrical conductors are disposed within the volume and connected directly or indirectly to a monitoring system.

Abstract: A method of detecting hypoxia. Detecting hypoxia includes detecting, in exhaled breath, at least one indicator for hypoxia. The at least one indicator is selected from the group consisting of pentanal, 2-pentanone, 2-hexanone, 2-heptanone, 2-cyclopenten-1-one, and 4-butyrolactone.

Abstract: Provided herein are details on the construction of a recombinant African Swine Fever Virus (ASFV) live attenuated vaccine for prevention of ASF caused by various strains of ASFV, such as the highly virulent Georgia 2007 isolate (“ASFV-G”). An exemplary vaccine comprises the ASFV-G?I1771 modified virus, a recombinant ASFV-G modified by deleting a portion of the I177L ORF rendering the I177L gene nonfunctional.

Abstract: The present invention relates to an innovative thermal design concept of tailoring the absorptance and emittance of a coating—namely silicon oxide (SiOx) coated aluminized Kapton—as a radiator coating for small, nano-satellite (i.e., CubeSat) thermal management. The present invention improves on the thermal design of existing satellites, by: a) thermally coupling all components to the baseplate to eliminate the need for heater power for the battery; b) using all six sides of the CubeSat as radiators by changing the wall material from fiberglass to aluminum; c) using a different ratio of absorptance to emittance for each side by tailoring the SiOx thickness; d) having a high emittance for the wall interior and components; and e) eliminating the need for MLIs. The elimination of the MLIs reduces the volume and increases the clearance to minimize the risk for solar array deployment and cost of the thermal control subsystem.

Abstract: A method of forming a doped substrate comprises heating a substrate comprising a layer of a dopant on at least one surface to a predetermined temperature; applying a predetermined degree of isostatic external pressure on the surface of said substrate at said predetermined temperature for a time sufficient to induce thermal migration of the dopant into the substrate to provide a doped substrate; and removing the isostatic pressure and cooling the doped substrate to about room temperature. The substrate is a glass material, a single crystal material, a poly-crystalline material, a ceramic material, or a semiconductor material, and the substrate may be optically transparent. The dopant comprises one or more transition metals, one or more rare earth elements, or a combination of both. The layer of a dopant comprises one or more segregated layers of distinct chemical species. The isostatic pressure and elevated temperature may be applied simultaneously or sequentially.

Abstract: Methods for the rapid amplification of extremely low quantity nucleic acids in a sample are provided. The disclosed methods are capable of amplifying less than 1 pg of DNA and/or RNA from a biological sample using a single tube and one-step or two-step preparation.

Abstract: A method for activating implanted dopants and repairing damage to dopant-implanted GaN to form n-type or p-type GaN. A GaN substrate is implanted with n- or p-type ions and is subjected to a high-temperature anneal to activate the implanted dopants and to produce planar n- or p-type doped areas within the GaN having an activated dopant concentration of about 1018-1022 cm?3. An initial annealing at a temperature at which the GaN is stable at a predetermined process temperature for a predetermined time can be conducted before the high-temperature anneal. A thermally stable cap can be applied to the GaN substrate to suppress nitrogen evolution from the GaN surface during the high-temperature annealing step. The high-temperature annealing can be conducted under N2 pressure to increase the stability of the GaN. The annealing can be conducted using laser annealing or rapid thermal annealing (RTA).

Abstract: Genetically engineered Foot and Mouth Disease Virus (FMDV) and related engineered proteins and polynucleotides, nanolipoprotein particles, compositions, methods and systems are described. The genetically engineered FMDV is modified by the strategic insertion of a protein tag into select regions of the FMDV genome which encode viral proteins that are exposed on the surface of the FMDV viral capsid. The inserted protein tag is displayed as a decoration or attachment on the viral capsid surface.