Abstract: A method for processing a signal from a lidar including digitizing the amplified electrical signal (s0e(t)), applying at least one time correction function, referred to as the correcting filter (Ce(t)), to the digitizing amplified electrical signal in order to generate a processed signal (sf(t)), the correcting filter (Ce(t)) being determined based on the impulse response and a predetermined time analysis function, the analysis function having at least one non-zero value, referred to as the discontinuity, at a given time referred to as the discontinuity time, with a return to substantially zero values around the discontinuity; and determining a distance (di) of the at least one element (Ei) based on the processed signal.

Abstract: The invention refers to an electronic component, in particular an organic electrochemical transistor (OECT) which comprises at least one gate electrode, a source electrode, a drain electrode, a channel and an electrolyte. The electrolyte is a solid electrolyte comprising a polymer, and the channel comprises an organic semiconductor as channel material. The electrolyte has a low water content and/or a low C1-C3-alcohol content as well as a low maximum halogen alkaline salt or alkaline earth or acetate salt content. The invention further refers to the use of this electronic component as a Schmitt-Trigger or a Muller-C-element or a flip-flop or a 1-bit memory. Further, the invention provides a method for forming such an electronic component.

Abstract: The invention provides luminescent lanthanide nanoparticles having simultaneously an improved brightness and an increased lifetime of the excited-state. These nanoparticles comprise terbium ions and ions of a second lanthanide, preferentially europium, and are coated with molecules of chromophore ligand bonded to the surface of the nanoparticle. The ligand is an organic molecule comprising at least one chromophore radical of formula I or of formula II: wherein R is selected from H, CN group or COOH group. The phosphorescence excited-state lifetime is improved by energy transfer from surface terbium ions to core ions of the second lanthanide. The nanoparticle may further comprise a carrier molecule of analytical interest covalently attached to at least one ligand molecule.

Abstract: This document provides methods and materials related to treating a disease. For example, this document provides methods for treating a subject's disease based on identifying the risk of progressive multifocal leukoencephalopathy PML using a genetic test.

Abstract: The present invention pertains to the field of nanoimprint lithography (NIL) processes and more specifically to a soft NIL process used for providing a sol-gel patterned layer on a substrate. Specifically, this process comprises a step of adjusting the solvent uptake of the sol-gel film to 10 to 50% vol., preferably between 15 and 40% vol., by varying the relative pressure of the solvent while a soft mould is applied onto the substrate coated with the sol-gel film.

Abstract: The invention is a method for processing a calibration spectrum acquired by a spectrometric detector of X or gamma photons. The method comprises a taking into account of a parametric form of a calibration function, the calibration function linking the rank of an energy channel to an energy value. The method comprises a confrontation between the channels of the peaks of the calibration spectrum and emission energies of calibration isotopes. The confrontation makes it possible to define the values of the parameters of the calibration function.

Abstract: This document provides methods and materials related to treating a disease. For example, this document provides methods for treating a subject's disease based on identifying the risk of progressive multifocal leukoencephalopathy PML using a genetic test.

Abstract: This document provides methods and materials related to treating a disease. For example, this document provides methods for treating a subject's disease based on identifying the risk of progressive multifocal leukoencephalopathy PML using a genetic test.

Abstract: A lidar system based on measuring a time-of-flight, including: an emission device configured to emit light pulses towards a scene at an angle greater than or equal to 5°; a reception device including: o a photodetector configured to receive pulses reflected or backscattered by at least one element of the scene and to convert the pulses into an electrical signal, an amplification circuit configured to amplify the electrical signal, a processing unit for processing the amplified electrical signal, configured to digitize the amplified electrical signal and determine a distance from the at least one element based on the digitized amplified electrical signal, the amplification circuit including a transimpedance amplifier, a transformer including a primary and a secondary, a capacitor and an inductor arranged in series with the capacitor.

Abstract: Disclosed are novel polymers that are grafted onto a substrate. These polymers contain monomer units derived from 4-vinylpyridine and monomer units derived from a co-monomer. The polymers may be complexed with a metal, and linear or crosslinked. Also disclosed are methods for preparing these polymers by radical polymerisation, as well as to their use for metal capture in aqueous media, particularly uranium capture in seawater or in final nuclear waste from nuclear power plants.

Abstract: An integrable, non-reciprocal optical component, with guidance, between two magneto-plasmonic interfaces each formed between a dielectric and a metal. An optical port and an input signal passes through a selection region providing a selected signal whose energy is concentrated in a single plasmonic mode, LRSPP or SRSPP, by a selection aperture of a width for which these modes have optical impedances that differ significantly from each other, one of which (z1eff) is close to, or equal to, the input optical impedance (z0eff). The selected signal passes through a differentiation region, which enhances the asymmetry between the two magneto-plasmonic interfaces, to concentrate its energy on a single magneto-plasmonic interface. The differentiated signal passes through a non-reciprocal treatment region formed by two magneto-plasmonic interfaces of non-equivalent geometries. The input signal will thus undergo different treatment from a reverse signal.

Abstract: The present invention relates to the fields of medicine and in particular cancer treatment. The invention more specifically relates to new compounds which are typically for use as a medicament. In particular, the invention relates to the use of these new compounds for increasing the presentation, typically the production and presentation, of Pioneer Translation Products (PTPs)-derived antigens by cells, in particular cancer cells, or changing the immunopeptidome, in a subject, and inducing or stimulating an immune response in the subject. The present disclosure also relates to uses of such compounds, in particular to prepare a pharmaceutical composition and/or to allow or improve the efficiency of a therapy in a subject in need thereof. The invention also discloses methods for treating a disease, in particular cancer, for preventing or treating cancer metastasis and/or cancer recurrence, in a subject.

Abstract: The invention relates to a method for attaching nucleic acids to a platinum electrode, comprising the following steps: —a step (S1) of attaching an ethylenediamine molecule to the electrode, step (S1) comprising electro-oxidation of a primary amine from the ethylenediamine molecule by cyclic voltammetry, —a step (S2) of attaching a sulfo SMCC molecule of 4-(N-maleimidomethyl)cyclohexane-1-carboxylic acid 3-sulfo-N-hydroxysuccinimide ester to the ethylenediamine molecule, —a step (S3) of attaching a nucleic acid to the sulfo SMCC molecule, the nucleic acid having been modified beforehand to comprise a thiol function, the electrode being in contact with an aqueous solution, i.e. with a solution in which the solvent is water, during steps (S1), (S2) and (S3).

Abstract: A device and a computer-implemented method for analyzing a dataset associated with a plurality of biological objects selected from cells, cell-derived vesicles, acellular microorganisms, and/or biofunctionalized materials; the dataset including N cytometric events, each associated with a biological object, each cytometric event being defined by at least two cytometric parameters measured for the corresponding biological object so that the dataset is represented by a cloud of N points in a D-dimensional space; the device and method being configured to output at least the hierarchical structure representing the different classes of biological objects and their mutual relationships.

Abstract: A method and system for characterizing media, in particular dielectric media, using a multifrequency resonator that is positioned remote from the region to be characterized and which is excited and interrogated remotely via inductive coupling to a probe. A reader measures, via a single channel, the complex impedance of this probe when it is coupled to the resonator and when this resonator interacts magnetically with the region to be characterized. The impedance is spectrally analyzed in order to extract therefrom individual complex impedances for each of the resonance frequencies of the resonator. These individual impedances are processed in order to calculate electrical properties of the medium, such as permittivity and/or conductivity, which provide information on the nature and/or change of the medium. Also, a multifrequency resonator provided for such a system or method.

Abstract: An array device composed of individual multifrequency passive resonators which are not electrically connected to one another. These resonators are formed by interrupted transmission lines that close back in on themselves and which are nested within one another, each formed of a group of two or more parallel tracks, and are paired with one another contactlessly around one or more dielectric layers of a substrate. Such an array is used in particular to modify an incident magnetic or electromagnetic field, and/or to carry out impedance matching by being placed between an incident field and a body or object to be treated or observed. It is also used to improve a method for contactlessly characterizing a medium to be investigated, via inductive coupling of one or more of the resonators of said array to a probe connected to a reader.

Abstract: Disclosed are compounds having the formula (I): wherein R1 represents a group: —NH2, —NHCORa, —NHCOORb, —(C2-C6)alkenylene-CO—NH—OH, —(C2-C6)alkynylene-CO—NH—OH or —OH; R2 represents a group: —OCH3, —OCH2CH3, —SCH3, —SCH2CH3 or —OCHF2; R3 represents a hydrogen atom or a group: —CH3, —CN, —F, —Cl or —ORc; R4 represents a hydrogen atom or a group: —CH3, —CN, —F, —Cl or —ORd; Ra represents a group: —(C1-C5)alkyl or —CF3; Rb represents a group: —(C1-C5)alkyl or —CF3; Rc represents a group: —(C1-C5)alkyl or —CF3; and Rd represents a group: —(C1-C5)alkyl or —CF3; in the state of a base or acid or acid salts or base salts or in the form of hydrate or of solvate. Also disclosed are drug conjugates including such compounds.

Abstract: The invention provides luminescent lanthanide nanoparticles having simultaneously an improved brightness and an increased lifetime of the excited-state. These nanoparticles comprise terbium ions and ions of a second lanthanide, preferentially europium, and are coated with molecules of chromophore ligand bonded to the surface of the nanoparticle. The ligand is an organic molecule comprising at least one chromophore radical of formula (I) or of formula (II): wherein R is selected from H, CN group or COOH group. The phosphorescence excited-state lifetime is improved by energy transfer from surface terbium ions to core ions of the second lanthanide. The nanoparticle may further comprise a carrier molecule of analytical interest covalently attached to at least one ligand molecule.

Abstract: A light-emission device includes at least one emission module comprising: a luminescent crystal known as a concentrator crystal with at least six faces which are parallel in pairs, including a first and a second face, known as lateral faces, perpendicular to a direction x and separated by a distance corresponding to a horizontal dimension of the concentrator in the direction x; a first mirror, which is configured such as to cover the first lateral face at least partly, defining a surface area covered by the first mirror, and at least one surface area (SFS1) which is not covered by the first mirror defining an associated output face; a second mirror, which is configured such as to cover at least 95% of the second lateral face; a brightness triggering element, which is designed to generate emission of brightness radiation (LF) in the luminescent crystal; a ratio R between the non-covered surface area (SFS1) and a surface area (SL) of the first lateral face being determined such that rays of the brightness radia

Abstract: The present invention relates to genetically modified bacteria capable of inducibly expressing a nucleic acid sequence of interest, genetic constructs, vectors and uses thereof.