Abstract: The disclosure relates to mutant recombinant influenza virus gene segment 7 with at least one mutation that modulates expression of M2 and M42 polypeptide. Also disclosed are recombinant influenza viruses comprising the mutant influenza virus gene segment 7, compositions comprising the mutant recombinant influenza virus gene segment 7, use of such mutant recombinant influenza virus gene segment 7 and mutant recombinant Influenza viruses.

Abstract: A processing system for a transmission apparatus, and an associated transmission apparatus and method, the processing system being configured to produce or generate a transmission signal representative of an original signal comprising data portions; the data being carried by or comprised in waveforms or streams in the transmission signal; the processing system being configured to generate the respective waveforms or streams by loading the data onto selected data symbols or subcarriers in the frequency domain to form the transmission signal.

Abstract: A method of detecting the presence of alpha-synuclein aggregation in a biological sample is provided whereby a biological sample is mixed with a reaction sample comprising a population of beads, a fluorophore adapted to bind to protein aggregates and to increase fluorescence when bound to protein aggregates, and alpha-synuclein or a fragment or variant thereof to form a reaction mixture, the reaction mixture is illuminated and at the same time incubated with intermittent agitation cycles, wherein a significant increase in the fluorescence of the reaction mixture during incubation is indicative of the presence of aggregates of alpha-synuclein in the biological sample. Method of diagnosing alpha-synucleinopathies such as Parkinson's disease or Dementia with Lewy Bodies.

Abstract: The present invention relates to methods and compositions useful for the prevention and/or treatment of PRRS in animals, typically domestic pigs. The invention relates to proteins which comprise fragments of CD163, nucleic acid constructs encoding such proteins, and methods of modifying expression or activity of CD163 in vivo.

Abstract: Immunogenic compositions containing Escherichia coli 0157:H7 flagella including fusion proteins and methods using the immunogenic compositions are disclosed. Inducing an immune response in an animal to Escherichia coli O157:H7 flagella will result in prevention of colonization by Escherichia coli O157:H7 in the animal or a reduction in the amount of Escherichia coli O157:H7 infecting the animal. The immune composition will prevent or reduce the attachment of Escherichia coli 0157:H7 to cells within the animal.

Abstract: The present invention is based on the identification of the adjuvant properties of inorganic (metal/metal oxide) nanoparticles. As such, the invention provides an adjuvant comprising, consisting or consisting essentially of inorganic nanoparticle. The invention also provides compositions and vaccines comprising the same as well as methods which exploit the adjuvant inorganic nanoparticles.

Abstract: The present invention provides an antigenically restricted subset of the highly variant PfEMP1 rosetting antigen which possess epitopes which may be exploited to raise immune responses effective against many diverse strains and isolates of the malaria parasite, Plasmodium falciparum. In this regard, the invention provides one or more P. falciparum Erythrocyte Membrane Protein-1 (PfEMP1) antigen(s) or a fragment or fragments thereof, for use in raising immune responses in humans.

Abstract: A single photon avalanche diode for use in a CMOS integrated circuit includes a deep n-well region formed above a p-type substrate and an n-well region formed above and in contact with the deep n-well region. A cathode contact is connected to the n-well region via a heavily doped n-type implant. A lightly doped region forms a guard ring around the n-well and deep n-well regions. A p-well region is adjacent to the lightly doped region. An anode contact is connected to the p-well region via a heavily doped p-type implant. The junction between the bottom of the deep n-well region and the substrate forms a multiplication region when an appropriate bias voltage is applied between the anode and cathode and the guard ring breakdown voltage is controlled with appropriate control of the lateral doping concentration gradient such that the breakdown voltage is higher than that of the multiplication region.

Abstract: A method of spatial modulation and associated transmission apparatus, receiver apparatus, computer program product and system for identifying a transmitter element within a transmission array of at least two transmitter elements, wherein a signal is transmitted by one active transmitter element at a time over a channel to a receiver. Power is allocated to the transmitter elements, wherein the power is allocated differently between at least two transmitter elements. The transmitted data is received at the receiver. The location of the active transmitter element is detected using knowledge of the power allocated to the transmitter elements.

Abstract: Disclosed is a hybrid wireless communication system and a communication method in the system. The system supports time and frequency division duplexing modes and includes a base station having a cellular communication range based on a cellular mode and mobile stations within the cellular communication range. The base station divides each available frequency resource into frames for communication, and each frame switches between a real-time service mode and a non-real-time service mode at a switching time within the frame. Communication is performed with the mobile stations within the cellular communication range via at least one of an uplink and a downlink in the real-time service mode of each frame according to the frequency division duplexing mode. Communication is performed with the mobile stations via the uplink and the downlink in the non-real-time service mode of each frame according to an ad hoc mode based on the time division duplexing mode.

Abstract: This invention relates to cationic lipids. More particularly the invention relates to biodegradable cationic lipids having a plurality of cationic headgroups and one or more lipophilic tail groups. The lipids are of utility in various applications, and in particular in permitting transfection of molecules, and in particular DNA and RNA, into cells. As such the lipids have specific utility in the field of gene therapy as well as other applications such as delivery of small molecules into cells, detergents, and metal ion complexation for medical or industrial applications.

Abstract: The present invention concerns methods of identifying extra-uterine (or ectopic) pregnancies and involves the screening of samples for the presence of certain molecules now known to be markers of extra-uterine pregnancies. The present invention provides a method for identifying an ectopic pregnancy, said method comprising the steps of: (a) providing a sample from a subject; (b) identifying a level of one or more of: (i) inhibin/activin BETA b subunit gene (ii) activin B (iii) cysteine-rich secretory protein 3 (CRISP-3); and/or (iv) carboxypeptidase-B1 (CPB1) (v) SLP1 (vi) elafin (vii) prolactin in the sample, wherein the level of inhibin/activin BETA b subunit gene, activin B, CRISP-3, SLP1, elafin, prolactin and/or CPB1 is associated with, or indicative of, an ectopic pregnancy.

Abstract: The present invention relates to an improved method for cleaning using plasma In particular, the present invention relates to the plasma cleaning and decontamination of instruments for use in medicine, dentistry and food preparation whereby the soiled item is exposed to a solvent and then to a plasma, whereby this enables excitation of water within the soil itself.

Abstract: A method of transmitting data from a transmitter to a receiver in an unsynchronized, ad-hoc, low-power, wireless network including: creating a packet including a header and data; and retransmitting the same created packet a plurality of times in succession.

Abstract: A ruthenium (II) compound of formula (I) wherein X is halo or a neutral or negatively charged O, N- or S-donor ligand; Y is a counterion; m is 0 or 1; q is 1, 2 or 3; A is either: (i) (Ru)—NRN1RN2—RN3—(N), where RN1 and RN2 are independently selected from H, optionally substituted C1-7alkyl, C3-20 heterocyclyl and C5-20aryl, and RN3 is C1-2alkylene; or (ii) a nitrogen-containing C5-6aromatic ring, wherein the nitrogen ring atom is bound to the ruthenium atom, and the ring is also bound to the azo-nitrogen, either by a single bond wherein the bond is ? or ? to the nitrogen ring atom, or by a —CH2? group wherein the bond is x to the nitrogen ring atom; B is optionally substituted C1-7alkyl, C3-20heterocyclyl or C5-20aryl.

Abstract: A treatment station for a water drainage conduit has a chamber with an inlet and outlet in fluid communication with upstream and downstream sections of the conduit and a sediment collection portion. Water enters the chamber via the inlet, collecting in the sediment collection portion until it reaches a level in the chamber such that it flows out of the outlet. A filter is mountable above the sediment collection portion for the upwards-flowing filtration of water passing through the chamber to remove organic contaminants. Access means are provided for removal and replacement of the filter and removal of solid material deposited in the sediment collection portion. The treatment station may also have by pass means which operate where the flow of water exceeds a rate which can flow through the filter and preliminary sediment collection chamber for collecting large quantities of sediment. Uses of the treatment station are also described.

Abstract: Disclosed is a hybrid wireless communication system and a communication method in the system. The system supports time and frequency division duplexing modes and includes a base station having a cellular communication range based on a cellular mode and mobile stations within the cellular communication range. The base station divides each available frequency resource into frames for communication, and each frame switches between a real-time service mode and a non-real-time service mode at a switching time within the frame. Communication is performed with the mobile stations within the cellular communication range via at least one of an uplink and a downlink in the real-time service mode of each frame according to the frequency division duplexing mode. Communication is performed with the mobile stations via the uplink and the downlink in the non-real-time service mode of each frame according to an ad hoc mode based on the time division duplexing mode.