Patents Assigned to The University Court of the University of Edinburgh
  • Patent number: 10520504
    Abstract: A probe for detecting bacteria and/or fungi in vitro and in vivo is provided, the probe having a core and a plurality of probe elements; each probe element within the plurality of probe elements extending from the core and having a fluorophore and a binding moiety, wherein the binding moiety is a bacteria binding moiety and selectively binds to bacteria and/or to fungi and not to animal cells. Methods of use of the probe and kits comprising the probe are also provided.
    Type: Grant
    Filed: November 13, 2015
    Date of Patent: December 31, 2019
    Assignee: The University Court of the University of Edinburgh
    Inventors: Mark Bradley, Annamaria Helena Lilienkampf, Nikolaos Avlonitis, Marc Vendrell Escobar, Neil Alexander McDonald, Christopher Haslett, Kanwaldeep Dhaliwal, Timothy Simon Walsh
  • Patent number: 10434191
    Abstract: The present invention relates to methods of visualising cells especially although not exclusively in vivo using a dye, such as a dendrimer-dye molecule or polybranched-dye molecule which is internalised by the cells and thus permits subsequent visualisation by confocal fluorescence endomicroscopy or other optical detectors. There is also provided internally quenched probes for use in visualising cells especially although not exclusively in vivo by confocal fluorescence endomicroscopy and the use of internally quenched probes in combination with confocal fluorescence endomicroscopy, for visualising cells by virtue of internalisation and dequenching of a probe by the cells. In a particular embodiment the cells are activated neutrophils, such as within the lung of a subject.
    Type: Grant
    Filed: January 23, 2017
    Date of Patent: October 8, 2019
    Assignee: THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH
    Inventors: Tashfeen Walton, Mark Bradley, Kev Dhaliwal, Nikolaos Avlonitis, Chris Haslett, Neil McDonald, Manuelle Debunne
  • Publication number: 20190296825
    Abstract: A method and associated access point for processing data for transmission to communication devices, the method comprising determining or receiving channel state information, CSI, relating to a plurality of the communication devices; for each of one or more sub-carriers, determining which communication devices can communicate using the respective subcarrier according to, or based on, the channel state information or data derived therefrom; allocating communication devices to sub-carriers upon which each communication device can communicate; and providing data for at least one or more or each communication device on the sub-carriers to which the respective communication device has been allocated. Preferably, the method uses an adaptive bit loading algorithm to allocate communication devices to sub-carriers.
    Type: Application
    Filed: October 6, 2017
    Publication date: September 26, 2019
    Applicant: The University Court of the University of Edinburgh
    Inventors: Zhe Chen, Harald Haas
  • Patent number: 10398576
    Abstract: A prosthesis (1) or an orthosis and method of operating the same. The prosthesis or orthosis comprising a moveable component (2), a motor (7) operable to move the component, wherein the motor has at least one operating parameter, the application of which to the motor results in the component having at least one operating condition; and an electronic device (28) operable to: determine at least one operating parameter of the motor and determine at least one instantaneous operating condition of the component from a predetermined operating profile of the motor and component and the determined at least one operating parameter of the motor, the predetermined operating profile of the motor and component being based on one or more operating parameter inputs to the motor and one or more resulting operating condition outputs of the component.
    Type: Grant
    Filed: August 17, 2012
    Date of Patent: September 3, 2019
    Assignees: Touch Bionics Limited, The University Court of the University of Edinburgh
    Inventors: Hugh Gill, Sethu Vijayakumar, Ian Saunders
  • Patent number: 10396894
    Abstract: A transmission system for transmitting data as part of a communications system, the data comprising a plurality of data symbols or elements, the transmission system being configured to divide the data into at least a first data portion and a second data portion, wherein the first data portion is communicated by transmitting signals in selected carrier channels, wherein the transmission system is configured to encode at least one data symbol or element by selecting a relative order of at least one first carrier channel having a first operational state and at least one second carrier channel having a second operational state.
    Type: Grant
    Filed: April 14, 2017
    Date of Patent: August 27, 2019
    Assignee: The University Court of the University of Edinburgh
    Inventors: Harald Haas, Sinan Sinanovic, Dobroslav Tsonev
  • Patent number: 10378005
    Abstract: The present invention relates to recombinant factor H and variants and conjugates thereof and methods of their production, as well as uses and methods of treatment involving the materials.
    Type: Grant
    Filed: April 10, 2017
    Date of Patent: August 13, 2019
    Assignee: UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH
    Inventors: Christoph Schmidt, Paul N. Barlow, Anna Richards
  • Patent number: 10363297
    Abstract: Immunogenic compositions containing Escherichia coli 0157:H7 flagella including fusion proteins and methods using the immunogenic compositions are disclosed. Inducing an immune response in an animal to Escherichia coli O157:H7 flagella will result in prevention of colonization by Escherichia coli O157:H7 in the animal or a reduction in the amount of Escherichia coli O157:H7 infecting the animal. The immune composition will prevent or reduce the attachment of Escherichia coli 0157:H7 to cells within the animal.
    Type: Grant
    Filed: November 23, 2015
    Date of Patent: July 30, 2019
    Assignees: The University Court of the University of Edinburgh, Moredun Research Institute, SRUC
    Inventors: David Gally, Tom Nathan McNeilly, David George Emslie Smith, Chris Low, Arvind Kumar Mahajan, Stuart W. Naylor
  • Patent number: 10294227
    Abstract: A first aspect of the invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or ester thereof, (Formula (I)) wherein: R1 is (CH2)mNR11R12; R2 is selected from H, halo, OR13, NHR13, alkyl, alkenyl and alkynyl; R3 is selected from alkyl, alkenyl, alkynyl, aryl, halo, aryloxy, NHCO2R4, NHCONR5R6, NHCOR7, NH-alkyl, NH-alkenyl, NH(CH2);n-aryl, (CH2)p-heteroaryl, (CH2)qCO2R8, (CH2)rCOR9 and NHSO2R10, wherein each alkyl, alkenyl, aryl or heteroaryl moiety in the aforementioned list is optionally further substituted by one or more groups selected from alkyl, halo OH, NH2, alkoxy, aryloxy, alkylamino, arylamino, carboxyl and carboxamide; R4 to R10 and R13 are each independently selected from alkyl, alkenyl and aryl; R11 and R12 are each independently selected from alkyl and alkenyl; or R11 and R:12 are linked together with the nitrogen to which they are attached to form a heterocycloalkyl or heterocycloalkenyl group; n, m, p, q and r are each independently selected from 0, 1, 2, 3, 4, 5
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: May 21, 2019
    Assignee: UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH
    Inventors: Asier Unciti-Broceta, Craig Fraser, Neil O. Carragher
  • Patent number: 10244739
    Abstract: The present invention relates to a genetically edited animal, especially to a genetically edited pig in which expression or activity of the RELA protein has been modified. Such pigs have at least partial protection against the African Swine Fever Virus. The invention also provides, a cell nucleus, germ cell, stem cell, gamete, blastocyst, embryo, foetus and/or donor cell of a non-human animal comprising a genetic modification which alters the expression or function of RELA protein, methods for editing the genome of animals and methods for screening the efficacy of a pharmaceutical agent in such an animal.
    Type: Grant
    Filed: March 1, 2013
    Date of Patent: April 2, 2019
    Assignee: The University Court of the University of Edinburgh
    Inventors: Christopher Bruce Alexander Whitelaw, Christopher James Palgrave, Simon Geoffrey Lillico
  • Patent number: 10236993
    Abstract: A transmission apparatus that produces, generates and/or transmits a unipolar signal representative of an original bipolar signal having one or more data frames, wherein each of the one or more frames of the original bipolar signal are converted into and/or transmitted as a plurality of unipolar portions, frames or frame portions of one or more information streams; and the transmission apparatus is configured to concurrently transmit the one or more information streams and at least one other information stream. Preferably, the different information streams are transmitted simultaneously on the same channel/link. Advantageously, one or more of the information streams are optionally arranged such that the interference due to the at least one other information stream on the at least one information stream does not adversely affect the information carried in the at least one information stream. The present invention also includes a corresponding receiver, system device and methods.
    Type: Grant
    Filed: September 12, 2014
    Date of Patent: March 19, 2019
    Assignee: THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH
    Inventors: Harald Haas, Dobroslav Tsonev
  • Publication number: 20190060262
    Abstract: The present invention relates to methods and compositions for enhancing expression from RNA expression vectores. The invention is based upon the observation that reducing the frequency of the dinucleotide CpG and UpA has a significant effect on expression from such vectores. Aspects of the invention include, amongst others, synthetic RNA vectores, virions, cells, methods of producing vaccines and methods of treatment or immunisation.
    Type: Application
    Filed: September 5, 2018
    Publication date: February 28, 2019
    Applicant: UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH
    Inventor: Peter Simmonds
  • Patent number: 10208166
    Abstract: A polyphosphonate, a lens including the polyphosphonate, a camera module including the polyphosphonate lens, and a method of producing the lens are provided. The polyphosphonate includes a constitutional repeating unit comprising a phosphate ester group and an aromatic ring, and the phosphate ester group is directly bonded to the aromatic ring in the constitutional repeating unit.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: February 19, 2019
    Assignees: Samsung Electro-Mechanics Co., Ltd., The University Court of The University of Edinburgh
    Inventors: Hoe-Chul Jung, Michael Patrick Shaver, Emily Kate Macdonald
  • Patent number: 10135528
    Abstract: A receiver system (100) having at least one receiver (101) for receiving optical communications signals (103b) that encode or transmit information; wherein the receiver system (100) is adapted to produce one or more electrical signals (104) from the received optical signal (103b) and/or from ambient light (103a) such that the receiver system (100) is usable as a source of electrical power and the encoded or transmitted information from the received optical communication signal (103b) is recovered or recoverable from the electrical signal(s) (104). Embodiments of the invention also relate to a communications system (400) that further comprises one or more transmitters (406) and a device having the receiver systems (401), along with associated methods of using and producing. Particular embodiments relate to identification tags (1000) and user devices (300) having a display (301) that at least partially overlaps the receiver(s) (302).
    Type: Grant
    Filed: December 2, 2014
    Date of Patent: November 20, 2018
    Assignee: The University Court of the University of Edinburgh
    Inventors: Dobroslav Tsonev, Harald Haas, Zixiong Wang, Stefan I. Videv, Tom Higgison
  • Patent number: 10122450
    Abstract: A communications system having at least one transmitter and at least one receiver, wherein the transmitters and/or receivers have an angular dependence, such that at least one response of the receivers to a received signal and/or at least one property of the signals transmitted by the transmitters is angularly dependent; the receiver and transmitter and/or the signals transmitted by the transmitters of two or more transmitter-receiver pairs have a distinct associated angular arrangement or relationship, wherein the at least one angularly dependent response of the receivers to the signal and/or the at least one angularly dependent property of the signal is dependent on the angular arrangement or relationship; and the system is configured to use the angularly dependent property and/or response to identify or discriminate the transmitter from which the signal was transmitted and/or at least one communication channel associated therewith.
    Type: Grant
    Filed: December 2, 2014
    Date of Patent: November 6, 2018
    Assignee: THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH
    Inventors: Stefan I. Videv, Dobroslav Tsonev, Harald Haas
  • Patent number: 10116423
    Abstract: A method and apparatus for communicating information by: dividing the information into at least a first information portion and a second information portion; modulating a plurality of domain resources to encode the first information using an index or grammar; and encoding the second information by modulation of domain resources. Optionally, the plurality of domain resources may be modulated to encode the first information by allocating at least two different modulation types to a plurality of sub-carriers. The modulation type is allocated to domain resources according to the index or grammar, which applies meaning to which modulation type is allocated to which domain resource. The modulation may include encoding part of the first information portion using one or more domain resources of a first domain and another part of the first information portion using one or more domain resources of a second domain.
    Type: Grant
    Filed: September 10, 2010
    Date of Patent: October 30, 2018
    Assignee: The University Court of the University of Edinburgh
    Inventors: Harald Haas, Rami Ismail Taha Abu-Alhiga
  • Patent number: 10035827
    Abstract: The present invention provides a recombinant protein capable of binding to complement factor H (CFH), and thereby inducing increased binding of C3d and C3b by bound CFH compared to unbound CFH. Methods and medical devices for using utilizing the same are also described.
    Type: Grant
    Filed: October 13, 2014
    Date of Patent: July 31, 2018
    Assignee: The University Court of the University of Edinburgh
    Inventors: Paul Barlow, Andrew Herbert, Elisavet Makou
  • Patent number: 9989658
    Abstract: A positron emission tomography (PET) data processing method comprises obtaining PET data from a PET detector, wherein the PET detector comprises an array of detector elements, and wherein the PET data is representative of a PET measurement of at least part of a subject. The method comprises identifying in the PET data a plurality of paired events, wherein each paired event comprises a first photon event in a first region of the PET detector and a second photon event in a second region of the PET detector. The first photon event comprises an energy deposition in a first detector element of the array or in a first detection region of the first detector element due to a scattering of a first photon at a first azimuthal scattering angle and an associated energy deposition by the scattered first photon in a second detector element of the array or in a second detection region of the first detector element or of the second detector element.
    Type: Grant
    Filed: June 12, 2017
    Date of Patent: June 5, 2018
    Assignee: THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH
    Inventors: Gary Douglas Smith, Daniel Watts
  • Patent number: 9974846
    Abstract: The present invention relates to the field of the veterinary medicine of bovine animals. In particular the invention relates to a recombinant Trypanosoma theileri parasite, preferably comprising a heterologous nucleic acid sequence that is capable of encoding a protein for instance an antigen, a cytokine, a hormone, an antimicrobial protein, or an antibody. Also disclosed are uses of and methods for making and using the recombinant T. theileri parasite in medical or non-curative treatments; in particular as a sustained delivery vector for proteins to bovine animals, e.g. as a vaccine.
    Type: Grant
    Filed: July 29, 2011
    Date of Patent: May 22, 2018
    Assignee: THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH
    Inventor: Keith Roland Matthews
  • Publication number: 20180127422
    Abstract: A first aspect of the-invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or ester thereof, (Formula (I)) wherein: R1 is (CH2)mNR11R12; R2 is selected from H, halo, OR13, NHR13, alkyl, alkenyl and alkynyl; R3 is selected from alkyl, alkenyl, alkynyl, aryl, halo, aryloxy, NHCO2R4, NHCONR5R6, NHCOR7, NH-alkyl, NH-alkenyl, NH(CH2);n-aryl, (CH2)p-heteroaryl, (CH2)qCO2R8, (CH2)rCOR9 and NHSO2R10, wherein each alkyl, alkenyl, aryl or heteroaryl moiety in the aforementioned list is optionally further substituted by one or more groups selected from alkyl, halo OH, NH2, alkoxy, aryloxy, alkylamino, arylamino, carboxyl and carboxamide; R4 to R10 and R13 are each independently selected from alkyl, alkenyl and aryl; R11 and R12 are each independently selected from alkyl and alkenyl; or R11 and R:12 are linked together with the nitrogen to which they are attached to form a heterocycloalkyl or heterocycloalkenyl group; n, m, p, q and r are each independently selected from 0, 1, 2, .3.
    Type: Application
    Filed: April 15, 2016
    Publication date: May 10, 2018
    Applicant: UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH
    Inventors: Asier UNCITI-BROCETA, Craig FRASER, Neil O.CARRAGHER
  • Publication number: 20180112193
    Abstract: The present invention relates to compositions of matter and methods of using the same in enhancing regeneration or restoring function of an injured liver. The compositions of matter are useful in the treatment of hepatic disorders, for example, in the prevention and/or treatment of acute or chronic liver disease or as a supportive therapy to improve the outcomes following liver resection or liver transplantation.
    Type: Application
    Filed: September 8, 2017
    Publication date: April 26, 2018
    Applicant: University Court Of The University Of Edinburgh
    Inventors: Stuart Forbes, David Hume, Ben Stutchfield, Deborah Gow, Graeme Bainbridge, Theodore Oliphant, Thomas L. Wilson