Abstract: The present invention is based on the identification of a number of genetic markers that are associated with susceptibility to Paget's disease of bone (PDB). This invention provides details of markers and nucleotide sequences as well as associated proteins/peptides and/or compositions and methods, for use in treating, preventing and/or detecting/diagnosing PDB and/or a susceptibility/predisposition thereto.

Abstract: A computer system for modelling and controlling a hydrocarbon reservoir through management of fluid flow at individual wells. The computer system has program instructions which operate a computer model which uses oilfield production data to provide a model of future production. The model comprises an optimal regression model which represents injector and producer wells whose fluid flow characteristics are highly correlated with the fluid flow characteristics of the well of interest; the application of parsimonious information criterion techniques to identify well pairs that statistically contribute information to the optimal regression model; and a statistical reservoir model comprising the product of the optimal regression model and a significance matrix. The system is also provided with control means, responsive to the output of the computer model in order to control wells in the hydrocarbon reservoir.

Abstract: The invention provides a cationic lipid comprising: (i) one head group, comprising one or more amino acids, in which at least one amino acid has a side chain that comprises a cationic moiety or a cationic precursor; (ii) a linking moiety of formula (5): —(HNR5)2NC(O)R3C(O)—??(5), wherein: each R5 is independently an optionally substituted C1-4 alkylene moiety; and R3 is an optionally substituted alkylene or alkenylene moiety; and (iii) two lipophilic moieties, wherein the head group and each of the lipophilic moieties are connected to the linking moiety through amide linkages.

Abstract: A system for testing visual fields comprising a display for presenting a visual stimulus and an eye tracker for tracking movement of at least one of a patient's eyes to determine its position in three dimensions without requiring the patient to wear any tracking equipment. A computer controls the position of the stimulus on the display and causes it to move by an amount that is a function of the tracked three-dimensional position of the patient's eye and a visual field position that is to be tested. Changes to the position of the stimulus and any corresponding tracked eye movement are used to assess the patient's visual field.

Abstract: A testing apparatus for testing a user's sustained attention comprises at least one stimulus-provider and a controller for controlling the stimulus-provider to provide at least one target stimulus, wherein the controller is configured to perform at least one operating procedure and the or each operating procedure comprises controlling the stimulus-provider to provide a sequence of target stimuli to the user.

Abstract: A method and apparatus for communicating information by: dividing the information into at least a first information portion and a second information portion; modulating a plurality of domain resources to encode the first information using an index or grammar; and encoding the second information by modulation of domain resources. Optionally, the plurality of domain resources may be modulated to encode the first information by allocating at least two different modulation types to a plurality of sub-carriers. The modulation type is allocated to domain resources according to the index or grammar, which applies meaning to which modulation type is allocated to which domain resource. The modulation may include encoding part of the first information portion using one or more domain resources of a first domain and another part of the first information portion using one or more domain resources of a second domain.

Abstract: The present invention provides avian CSF1 genes encoding proteins which bind avian colony stimulating factor 1 receptor (CSF1R) and which exhibit immunomodulatory properties.

Abstract: A position determining unit has an assistance data processing and relaying module (software client) (1318) that obtains localised assistance data, such as Global Navigation Satellite Systems (GNSS) assistance data and/or non-GNSS (such as Wireless Positioning System) assistance data, from an assisting peer position determining unit and relays the localised assistance data to an assisted peer position determining unit. The relaying may be done via an assistance server. In a relaying GNSS position determining unit, such as a GPS receiver, the chip (1310) architecture has multi-frequency GNSS baseband (1311), GSM or UMTS baseband (1312) for long range communication and short range baseband (1313) such as Bluetooth or Wi-Fi or UWB. The assistance data generating module (1316) generates localised assistance data at the relaying GNSS unit from the GNSS R.F. front end and/or GNSS baseband and/or microcontroller running the GNSS solutions software portion.

Abstract: Methods for differentiating primate pluripotent stem cells into hepatocyte-lineage cells are provided. In certain embodiments, the methods utilize sequential culturing of the primate pluripotent stem cells in certain growth factors to produce hepatocyte-lineage cells. In certain embodiments, the population of cells produced by the methods is further enriched for hepatocyte-lineage cells.

Abstract: A method for remediating land contaminated by a combustible material, in particular, land contaminated with non-aqueous phase liquids (NAPLs), which includes the steps of locating a subterranean volume of combustible material such as a DNAPL in land to be remediated, and igniting the combustible material to combust the material and thereby remediate the land. By monitoring combustion of the material, combustion may be optimised by, for example, supplying an oxidant or a combustion suppressant.

Abstract: Disclosed is a data input device for providing a plurality of input signals responsive to user actions, comprising a resilient body and one or more sensors within the resilient body, which typically has a shape defining one or more modes of deformation, operable to provide the input signals responsive to deformation of the resilient body, by the actions of a user by virtue of the forces transmitted through the resilient body to the one or more sensors. By providing a deformable resilient body, typically defining one or more modes of deformation, only a subset of the plurality of input signals respond significantly to the deformation (typically to degree of deformation), a user lacking fine motor skills is able to better control a plurality of input signals.

Abstract: A method of operating a mobile telecommunications system having a base station, a plurality of users and a plurality of spectral resource blocks, some of which are not allocated to users. The method includes, (a) for each user, assigning a score to each resource block based on the energy efficiency with which the user can use the resource block, and determining which of the plurality of resource blocks is favored, i.e. has a score indicating that it will be the most energy efficient for the user. For each user, either (b) if the user's favored resource block is not allocated, and is not favored by any other user, that resource block is allocated to that user; or (c) in the event that the same resource block is favored by more than one user, it is allocated to the user who will use it with the greatest energy efficiency.

Abstract: The present invention provides methods for identifying whether or not a patient has, or is at risk of developing drug induced organ damage and methods of treating patients having drug induced organ damage. In particular, the invention relates to a method for identifying whether or not a patent has, or is at risk of developing paracetamol induced liver damage.

Abstract: The present invention relates to an electrode assembly having a laminate structure comprising: a first insulating capping layer; a first conducting layer capped by the first insulating capping layer and substantially sandwiched by at least the first insulating capping layer such as to leave exposed only an electrical contact lip of the first conducting layer; and an array of etched voids extending through at least the first insulating capping layer and the first conducting layer, wherein each void is partly bound by a surface of the first conducting layer which acts as an internal submicron electrode.

Abstract: The present invention relates to a method of isolating fragments of nucleic acid according to the density of CpG dinucleotides and subsequent procedures for producing a library and/or an array or microarray of these fragments, as well as uses thereof.

Abstract: A capacitive switch for microelectromechanical systems (MEMS) comprises a topmost metal plate which extends across a bridge structure formed by a polymer layer. The polymer layer comprises poly-monochoro-para-xylene (parylene-C). The space below the polymer layer contains the second plate on a substrate. Using parylene as the primary bridge material makes the bridge of the MEMS device very flexible and requires a relatively low actuation voltage to pull the bridge down and lower power is required to control the MEMS device.

Abstract: A spatial modulation method and transmitting and receiving apparatuses using the spatial modulation method in a MIMO system are provided. The spatial modulation method uses an index of an activated antenna and a signal modulation constellation as an information source. The spatial modulation method is applied to the transmitting apparatus. The receiving apparatus uses a spatial modulation detection method in which a channel path gain is repeatedly multiplied to detect the spatially modulated signal efficiently.

Abstract: Provided is a multiple-input multiple-output (MIMO) data transmission method. A transmitter generates a transmission symbol by adding a parity symbol to a predetermined number of data symbols, generates a preprocessed symbol by multiplying the predetermined number of transmission symbols by a preprocessing matrix in units of blocks, selects a transmission antenna associated with a non-zero transmission symbol among preprocessed transmission symbols constituting the preprocessed symbol, and transmits the preprocessed symbol via the selected transmission antenna. A receiver receives a signal transmitted from the transmitter, estimates a preprocessed symbol and a transmission antenna index from the received signal, and restores the transmission symbols using the estimated preprocessed symbol and transmission antenna index.

Abstract: The invention relates to a generator, to a magnetic flux conducting unit for a generator, and to a power generation machine comprising such a generator. In an embodiment of the invention, a generator is disclosed which comprises at least one coil assembly and at least one magnetic flux conducting unit. The magnetic flux conducting unit comprises at least one magnet, a pair of opposed magnetic flux conducting elements defining a space therebetween for receiving the coil assembly, and at least one connection portion extending between the opposed magnetic flux conducting elements. The at least is arranged relative to the opposed magnetic flux conducting elements such that the magnetic attraction forces between the elements are redacted through and balances with the connection portion.