Abstract: The present disclosure relates to vaccines and methods for the prevention and treatment of Zika virus infection. Particularly, the present disclosure relates to viral and DNA vaccine vectors which includes or encode for secreted immunogenic peptides of NS1 that eliciting a protective immune response and prevent Zika virus infection of a subject.

Abstract: The present disclosure relates to methods, products and systems for the prognosis of subjects suffering from multiple myeloma. In certain embodiments, the present disclosure provides a method of prognosis for a subject suffering from multiple myeloma. The method comprises determining the level of desmoglein 2 (DSG2) in malignant plasma cells from the subject, wherein an increased level of DSG2 in the plasma cells is indicative of a poorer prognosis for the subject.

Abstract: The present disclosure relates to non-surgical methods for delivery of an agent to the respiratory system of a subject, methods of treatment using delivery of agents to the respiratory system, devices for delivery of agents to the respiratory system, and use of such devices to deliver agents to the respiratory system. In certain embodiments, the present disclosure provides a provide a non-surgical method of delivering an agent to the respiratory system of a subject. The method comprises in vivo perturbation of the airway surface in one or more parts of the respiratory system in the subject and exposing the perturbed surface of the airway to the agent, thereby delivering the agent to the respiratory system of the subject.

Abstract: A cell culture microdevice for maintaining and culturing a cell therein comprising a cell culture unit having at least a first cell carrier unit defining a cell culture chamber formed therein, the first cell carrier unit formed from at least, a chamber base shaped to support the cell thereon, and one or more chamber walls having one or more chamber wall surfaces enclosing the cell culture chamber about a chamber boundary, the first cell carrier unit further providing a guiding surface to guide instruments or fluids into the cell culture chamber located at an aperture through a chamber wall, wherein the cell culture microdevice is configured at a scale to substantially enclose a single cell or cell mass therein. Embodiments of the cell culture microdevice may be suitable for in vitro fertilisation procedures and drug efficacy testing.

Abstract: A new slow-release fertilizer is described that is formed by applying graphene oxide (GO) as a carrier for micronutrients such as copper (Cu) and zinc (Zn), in which the micronutrients are efficiently bonded with the functional groups at the surface and sides of the GO sheets due to their affinity to the unpaired oxygen atoms in the GO. The prepared Cu-graphene oxide (Cu-GO) and Zn-graphene oxide (Zn-GO) fertilizers showed a biphasic dissolution behaviour compared to commercial zinc sulphate (ZnSO4) and copper sulphate (CuSO4) fertilizer granules, displaying both fast- and slow-release micronutrient release.

Abstract: The present disclosure relates to methods and products for reducing adhesions. In certain embodiments, the present disclosure provides a method of reducing adhesions in a subject, the method comprising exposing a region in the subject susceptible to formation of an adhesion to an agent having iron chelation and/or antioxidant activity, thereby reducing adhesions in the subject.

Abstract: A novel energy storage battery system is described that includes a highly reversible electrolytic Zn—MnO2 system in which electrodeposition/electrolysis of Zn (anode side) and MnO2 (cathode side) couple is employed with a theoretical voltage approximately 2 V and energy density of approximately 409 Wh kg?1 providing superior durability and excellent energy densities.

Abstract: A mutant subtilase cytotoxin B subunit protein is provided which can bind glycans having ?2-3-linked N-glycolylneuraminic acid and glycans having ?2-6-linked N-glycolylneuraminic acid. The mutant SubB protein has deletions of one or more of the amino acid sequence TTSTE and has a previously undescribed ability to bind glycans having ?2-6-linked N-glycolylneuraminic acid, while not losing the ability to bind glycans having ?2-3-linked N-glycolylneuraminic acid.

Abstract: The present disclosure relates to methods and products for reducing the viability of microorganisms, and to methods and products for preventing and/or treating microorganism infections. Certain embodiments of the present disclosure provide a method for reducing viability of a microorganism. The method comprises exposing the microorganism to an effective amount of an iron chelator and subsequently exposing the microorganism to an effective amount of a non-iron porphyrin, thereby reducing the viability of the microorganism.

Abstract: The present disclosure relates to a bicycle frame and associated bicycle components, and to reducing the aerodynamic drag of these. In one aspect, there is provided an elongate structural member of a bicycle frame, the member comprising a lengthwise extending leading edge, the leading edge comprising at least a pair of forwardly extending protrusions spaced apart lengthwise therealong. In one form, the protrusions comprise tubercles, a series of which are spaced apart lengthwise along the leading edge, and which further extend to at least one side of the leading edge so as to transition into a chordwise extending rib.

Abstract: An exhaust duct assembly for conveying exhaust gases emanating from a combustion zone to atmosphere is disclosed. The assembly includes: an exhaust gas outlet for exhausting exhaust gas into the atmosphere; and an acoustic duct portion located upstream of the exhaust gas outlet, the acoustic duct portion having a peripheral wall defining a through-passage arranged and constructed to promote propagation of sound there-through. The acoustic duct portion has a length in a flow direction that is at least 50% of an average hydraulic diameter of the through-passage.

Abstract: The present invention relates to a method of improving fire retardant properties of a substrate, the method comprising providing the substrate with a graphene-based composite, wherein the graphene-based composite comprises graphene-based material intercalated with inorganic metal hydrate.

Abstract: A system for generating a pressure signal in a pipeline system containing a pressurised fluid is disclosed The system includes a discharge valve in fluid communication with the pressurised fluid of the pipeline system to allow fluid from the pipeline system to discharge and an electronic controller to dynamically control a degree of opening of the discharge valve to selectively vary the discharge valve between a plurality of valve opening states to generate the pressure signal in the pipeline.

Abstract: A method for preventing or reducing the risk of perinatal or neonatal morbidity and mortality caused by antenatal inflammation in humans is described. This method is based on the administration of a compound of formula I or a pharmaceutically acceptable salt thereof: to an expectant human mother suffering from antenatal fetal inflammation. The method prevents or reduces the risk of organ damages, including brain, lung and intestinal damages, and sequelae therefrom, in the neonates, as well as the risk of neonatal death.

Abstract: The present disclosure relates to vaccines and methods for the prevention and treatment of Zika virus infection. Particularly, the present disclosure relates to viral and DNA vaccine vectors which includes or encode for secreted immunogenic peptides of NS1 that eliciting a protective immune response and prevent Zika virus infection of a subject.

Abstract: A new slow-release fertilisers is described that is formed by applying graphene oxide (GO) as a carrier for micronutrients such as copper (Cu) and zinc (Zn), in which the micronutrients are efficiently bonded with the functional groups at the surface and sides of the GO sheets due to their affinity to the unpaired oxygen atoms in the GO. The prepared Cu-graphene oxide (Cu-GO) and Zn-graphene oxide (Zn-GO) fertilizers showed a biphasic dissolution behaviour compared to commercial zinc sulphate (ZnSO4) and copper sulphate (CuSO4) fertilizer granules, displaying both fast- and slow-release micronutrient release.

Abstract: A temperature sensor and temperature sensing system for sensing changes in temperature up to a predetermined temperature is disclosed. The temperature sensor includes a microstructured optical fiber where the microstructured optical fiber includes a plurality of longitudinal channels extending along the microstructured optical fiber. The sensor also includes a fiber Bragg grating formed in the microstructured optical, fiber by generating a periodic modulation in the refractive index along a core region of the microstructured optical fiber. The fiber Bragg grating is operable to produce band reflection at a reflection wavelength that varies in accordance with changes in temperature at the core region of the optical fiber.

Abstract: A method and system for assessing the condition of a pipeline in a pipeline system is disclosed. The method includes generating a pressure wave in the fluid being carried along the pipeline system at a generation location along the pipeline system, detecting a first pressure wave interaction signal at a first measurement location along the pipeline system resulting from an interaction of the pressure wave with localised variations in the pipeline and then detecting synchronously a second pressure wave interaction signal at a second measurement location along the pipeline system resulting from the interaction of the pressure wave with localised variations in the pipeline.

Abstract: A solar receiver for exposing heat absorbing particles to concentrated solar radiation. The solar receiver includes a chamber having an aperture through which concentrated solar radiation can be received within the chamber. An inlet means provides for introducing an inflow including solar absorbing particles into the chamber. An outlet means provides for discharge of an outflow from the chamber. The inlet means communicates with the chamber for introduction of the inflow into a first section of the chamber in opposed relation the aperture. The outlet means communicates with a second section of the chamber disposed between the first section and the aperture, wherein fluid flow from the inlet means to the outlet means is exposed to concentrated solar radiation received within the chamber. The first section diverges in a direction towards the aperture, and the inlet means is configured to introduce the inflow tangentially into the divergent first section.

Abstract: A method for the production of hydrocarbon(s), such as methane, substituted hydrocarbons, such as methanol, or the production of hydrogen, the method comprising the steps of contacting a first catalyst with water in order to photocatalyse the splitting of at least some of the water into hydrogen and oxygen; and contacting a second catalyst with a gas stream comprising carbon dioxide and at least some of the hydrogen produced from step (a) in order to photocatalyse the reaction between the hydrogen and carbon dioxide to produce hydrocarbon(s), such as methane, and/or substituted hydrocarbons, such as methanol. In an embodiment, the catalyst comprises gold and or ruthenium nanoclusters supported on a substrate.