Patents Assigned to The University of Akron
  • Patent number: 9891237
    Abstract: Hydroxyphenylbenzazole compounds that are useful for the selective detection of zinc, aluminum, chromium, and iron cations in vitro and in vivo. The Hydroxyphenylbenzazole compounds include a 2-hydroxyphenyl group bound to a single benzazole group; a first ligand group that is a Schiff base moiety; and a second ligand group selected from a Schiff base moiety and a hydroxyl group.
    Type: Grant
    Filed: July 24, 2014
    Date of Patent: February 13, 2018
    Assignee: THE UNIVERSITY OF AKRON
    Inventors: Yi Pang, Junfeng Wang
  • Patent number: 9885070
    Abstract: The invention relates to functionalized, telechelic polymers synthesized by enzymatic catalysis and methods, and the functionalization of polymers via Michael addition with a lipase catalyst, and the crosslinking of mono- or difunctional (telechelic) polymers made by enzymatic catalysis, such as by using multifunctional coupling agents and enzyme catalysts. Quantitative transesterification of vinyl methacrylate with poly(ethylene glycol), poly(isobutylene) and poly(dimethylsiloxane) was achieved using Candida antarctica lipase B. In addition, methacrylate-functionalized poly(ethylene glycol) monomethyl ether has been successfully coupled to aminoethoxy poly(ethylene glycol) monomethyl ether via Michael addition using Candida antarctica lipase B. Amine-functionalized poly(ethylene glycol)s have also been used for the preparation of poly(ethylene glycol)-based dendrimers and gels through Michael addition of the polymer onto triacryloyl hexahydro-triazine using the same enzyme.
    Type: Grant
    Filed: April 3, 2014
    Date of Patent: February 6, 2018
    Assignee: The University of Akron
    Inventors: Judit E Puskas, Mustafa Yasin Sen
  • Patent number: 9878049
    Abstract: A high drug loading system is described comprising of at least one anticancer drug; at least one peptide; and at least one nucleic acid.
    Type: Grant
    Filed: October 9, 2014
    Date of Patent: January 30, 2018
    Assignee: THE UNIVERSITY OF AKRON
    Inventors: Gang Cheng, Qiong Tang, Bin Cao
  • Patent number: 9874552
    Abstract: Provided are multi-phase systems that may be used to prepare a three-dimension aggregate of cells referred to as a cellular spheroid. The multi-phase system includes a droplet of an aqueous polymer phase within an immersion aqueous polymer phase. The droplet of the droplet aqueous polymer phase contains a three-dimensional aggregate of cells (cellular spheroid). Types of cells that may be used in the multi-phases system include stem cells and cancer cells. The cellular spheroids with the multi-phase system may be used to monitor cell growth in three-dimensional systems, or screen drugs in a three-dimension aggregate of cells.
    Type: Grant
    Filed: September 30, 2015
    Date of Patent: January 23, 2018
    Assignee: The University of Akron
    Inventors: Hossein Tavana, Ehsan Atefi, Stephanie Lemmo Ham
  • Patent number: 9865894
    Abstract: A direct-electrochemical-oxidation fuel cell for generating electrical energy includes a cathode provided with an electrochemical-reduction catalyst that promotes formation of oxygen ions from an oxygen-containing source at the cathode, a solid-state reduced metal, a solid-state anode provided with an electrochemical-oxidation catalyst that promotes direct electrochemical oxidation of the solid-state reduced metal in the presence of the oxygen ions to produce electrical energy, and an electrolyte disposed to transmit the oxygen ions from the cathode to the solid-state anode. A method of operating a solid oxide fuel cell includes providing a direct-electrochemical-oxidation fuel cell comprising a solid-state reduced metal, oxidizing the solid-state reduced metal in the presence of oxygen ions through direct-electrochemical-oxidation to obtain a solid-state reducible metal oxide, and reducing the solid-state reducible metal oxide to obtain the solid-state reduced metal.
    Type: Grant
    Filed: September 2, 2015
    Date of Patent: January 9, 2018
    Assignees: The University of Akron, The Ohio State University
    Inventors: Steven S. Chuang, Liang Shih Fan
  • Patent number: 9851337
    Abstract: The present invention is directed to a water condition monitoring device and related methods of use that significantly reduce the cost of the water condition monitoring devices by replacing the expensive and bulky multiple sensor electrodes of currently available devices with a single set of two or three metal electrodes to detect and/or measure such water quality parameters as pH, electric conductivity, temperature, and dissolved oxygen content. A microcontroller activates each sensor one at a time in a continuous loop, processing the sensor signals into near real time water condition data, which may be stored, displayed, or sent to a remote location for storage or display.
    Type: Grant
    Filed: December 8, 2014
    Date of Patent: December 26, 2017
    Assignee: The University of Akron
    Inventors: Kye-Shin Lee, Ajay Mahajan
  • Publication number: 20170362458
    Abstract: Various embodiments of the present invention are directed to switchable carboxybetaine-based polymers, hydrogels, and/or elastomers, along with novel related monomers, crosslinkers, and methods. Under acidic conditions, the materials undergo self-cyclization and can catch and kill bacteria. Under neutral/basic conditions, these materials undergo ring-opening and can release killed bacterial cells and resist protein adsorption and bacterial attachment. These smart polymers, hydrogels and elastomers also show excellent mechanical properties making them highly desirable for many biomedical applications.
    Type: Application
    Filed: May 30, 2014
    Publication date: December 21, 2017
    Applicant: THE UNIVERSITY OF AKRON
    Inventors: Gang CHENG, Bin CAO
  • Patent number: 9846014
    Abstract: A ballistic material utilizes a three-dimensional, square-based pyramid unit cell (SBPUC) sphere structure that includes four base spheres and a primary sphere, which are tightly packed and in contact with each other. The base spheres and the primary sphere are arranged whereby the centers of each of the base spheres form corners of a square base, while the center of the primary sphere forms an apex, which when connected to the corners, forms an imaginary pyramid. The ballistic material is formed from one or more layers of SBPUCs that are provided between a pair of spaced substrate layers, so as to achieve the desired level of ballistic protection performance.
    Type: Grant
    Filed: December 3, 2014
    Date of Patent: December 19, 2017
    Assignee: THE UNIVERSITY OF AKRON
    Inventors: Xiaosheng Gao, Yibin Fu
  • Patent number: 9845318
    Abstract: 2,5-Bis(benzoxazol-2?-yl)benzene-1,4-diol derivatives (Zinhbo derivatives) are used to detect zinc ions and have particular application in vivo and in vitro. Zinhbo derivatives upon excitation give a florescence response emission that can be used to determine the presence of zinc cation in solution. Zinhbo derivatives complexed with zinc cations upon excitation can produce a florescence response emission in the visible and near infrared range. Zinhbo derivatives complexed with zinc cations exhibit a large stoke shift between the excitation and emission wavelengths.
    Type: Grant
    Filed: February 3, 2015
    Date of Patent: December 19, 2017
    Assignee: The University of Akron
    Inventors: Yi Pang, Yongqian Xu
  • Patent number: 9847211
    Abstract: A method for making a conductive film includes the steps of: depositing a conductive metal film on a substrate to form a metal-coated substrate; depositing a fiber pattern on the conductive metal film of the metal-coated substrate to form a masked substrate, the fiber pattern defining protected metal and exposed metal of the conductive metal film; removing the exposed metal from the conductive metal film of the masked substrate to form a protected conductive film; and removing the fiber pattern from the protected conductive film to expose the protected metal and provide a metal pattern on the substrate. An annealing step con be employed after depositing the fiber pattern to increase the surface area of contact between the fiber pattern and the conductive metal film.
    Type: Grant
    Filed: January 16, 2015
    Date of Patent: December 19, 2017
    Assignee: The University of Akron
    Inventors: Yu Zhu, Tianda He
  • Publication number: 20170355815
    Abstract: The present invention provides a low molecular mass PPF polymer (and related methods) that is suitable for 3D printing and other polymer device fabrication modalities and can be made inexpensively in commercially reasonable quantities. These novel low molecular mass PPF polymers have a low molecular mass distribution (m) and a wide variety of potential uses, particularly as a component in resins for 3D printing of medical devices. The ability to produce low m PPF creates a new opportunity for reliable GMP production of PPF. It provides low cost synthesis and scalability of synthesis, blending of well-defined mass and viscosity PPF, and reduced reliance on solvents or heat to (a) achieve mixing of 3D printable resins or (b) and flowability during 3D printing. These PPF polymers are non-toxic, degradable, and resorbable and can be used in tissue scaffolds and medical devices that are implanted within a living organism.
    Type: Application
    Filed: November 18, 2015
    Publication date: December 14, 2017
    Applicants: THE UNIVERSITY OF AKRON, THE OHIO STATE UNIVERSITY
    Inventors: Matthew BECKER, Howard DEAN, Yuanyuan LUO
  • Patent number: 9834622
    Abstract: The present invention generally relates to alcohol-terminated polyisobutylene (PIB) compounds, and to a process for making such compounds. In one embodiment, the present invention relates to primary alcohol-terminated polyisobutylene compounds, and to a process for making such compounds. In still another embodiment, the present invention relates to polyisobutylene compounds that can be used to synthesize polyurethanes, to polyurethane compounds made via the use of such polyisobutylene compounds, and to processes for making such compounds. In yet another embodiment, the present invention relates to primary alcohol-terminated polyisobutylene compounds having two or more primary alcohol termini and to a process for making such compounds. In yet another embodiment, the present invention relates to primary terminated polyisobutylene compounds having two or more primary termini selected from amine groups or methacrylate groups.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: December 5, 2017
    Assignee: The University of Akron
    Inventors: Joseph Kennedy, Yongmoon Kwon, Subramanyam Ummadisetty
  • Patent number: 9827709
    Abstract: The present invention is directed to synthetic attachment discs made from adhesive nanofibers and/or microfibers that are capable of attaching long fibers to a wide variety of surfaces, and related methods for forming and using them. The synthetic attachment discs of the present invention use very little material relative to prior art systems, while producing a very strong attachment force. Experimental and theoretical evidence are provided to confirm the advantages of thousands of micron-size ‘staple-pins’ and their low peeling angles to enhance the adhesive forces required to peel the synthetic attachment discs. The present invention provides a unique strategy for designing new adhesives that use very little material for various biomedical and material science applications.
    Type: Grant
    Filed: December 23, 2013
    Date of Patent: November 28, 2017
    Assignee: The University of Akron
    Inventors: Ali Dhinojwala, Vasav Sahni, Dharamdeep Jain
  • Patent number: 9828597
    Abstract: The present invention relates to compositions and a process in the field of self-cleaning system using digestive proteins. One composition includes a substrate, a digestive protein capable of decomposing a stain molecule, and a link moiety bound to both said digestive protein and said substrate. An alternative composition includes a digestive protein capable of decomposing a stain molecule and a coating substrate wherein said digestive protein may be dispersed in said coating substrate. The process claim includes binding a substrate to a surface and forming a linker moiety between a digestive protein and said substrate.
    Type: Grant
    Filed: November 22, 2006
    Date of Patent: November 28, 2017
    Assignees: Toyota Motor Engineering & Manufacturing North America, Inc., Toyota Motor Corporation, The University of Akron
    Inventors: Ping Wang, Minjuan Zhang, Hongfei Jia, Archana H. Trivedi, Masahiko Ishii
  • Patent number: 9830691
    Abstract: The present invention relates to a method capable of real-time implementable local tone mapping of high dynamic range images. In one embodiment, the present invention relates to a method capable of accomplishing real-time local tone mapping of high dynamic range images so that they have clear details without, for example, halo artifacts when viewed on standard display devices. In another embodiment, the present invention relates to a method capable of accomplishing real-time local tone mapping of high dynamic range images so that they have clear details without, for example, halo artifacts when viewed on standard display devices where such a method utilizes, in part, a modified Reinhard operator.
    Type: Grant
    Filed: August 4, 2008
    Date of Patent: November 28, 2017
    Assignee: The University of Akron
    Inventors: Joan Elizabeth Carletta, Firas Hussein Hassan
  • Patent number: 9821310
    Abstract: Exemplary embodiments of the present disclosure provide for two-stage microfluidic devices using surface acoustic waves, methods of use thereof, methods of making, methods of focusing and separating particles, and the like.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: November 21, 2017
    Assignee: The University of Akron
    Inventors: Rasim Oytun Guldiken, Myeong Chan Jo, Jiang Zhe
  • Publication number: 20170327635
    Abstract: The present invention is directed to a versatile and high performance zwitterionic CP platform, which integrates all desired functions into one material. This zwitterionic CP consists of the conducting backbone and multifunctional zwitterionic side chains. Non-conducting zwitterionic materials gain electronic conductivity through the conducting backbone and CPs obtain excellent biocompatibility, sensitivity to environmental stimuli and controllable antifouling properties via multifunctional zwitterionic side chains. Unique properties from two distinct materials (conducting materials and zwitterionic materials) are integrated into one material without sacrificing any properties. This platform can potentially be adapted for a range of applications (e.g. bioelectronics, tissue engineering, wound healing, robotic prostheses, biofuel cell, etc.), which all require high performance conducting materials with excellent antifouling/biocompatibility at complex biointerfaces.
    Type: Application
    Filed: May 19, 2017
    Publication date: November 16, 2017
    Applicant: The University of Akron
    Inventor: Gang Cheng
  • Patent number: 9814607
    Abstract: A prosthesis includes a socket for receiving a residual limb, the socket having a socket wall defining a limb-receiving surface; a heat pipe including a working fluid and a wicking structure, the heat pipe having a socket section and a heat sink section, the heat pipe extending along its length through the socket wall proximate to or exposed at the limb-receiving surface, wherein the working fluid has a boiling point of from about 0° C. to 90° C. such that the working fluid is adapted to evaporate to form vapor under the influence of the heat of a residual limb in the socket thus drawing heat from and cooling the residual limb. A heat sink section of the heat pipe passes through the heat sink, the heat sink reducing the temperature of the working fluid.
    Type: Grant
    Filed: May 7, 2014
    Date of Patent: November 14, 2017
    Assignee: The University of Akron
    Inventors: Jiang Zhe, Yu Han
  • Patent number: 9809908
    Abstract: Microscale and nanoscale tubular structures are provided including rheological fluids in their interior volume and including at least one electroactive component. Multiple tubular structures are provided, including simple hollow tube structures; core/shell structures, wherein the tube includes a tubular outer shell with a core extending axially therein; concentric tube or coaxial tube structures, wherein the tube includes a tubular outer shell and one or more concentric tubes extending axially therein; and core/concentric tube structures, wherein concentric tubes further include a core extending axially therein, thus having a core and two or more tubes surrounding the core. The tubular structures are formed by electrospinning and special spinnerets are provided. The tubular structures form fabrics for beneficial uses.
    Type: Grant
    Filed: January 20, 2014
    Date of Patent: November 7, 2017
    Assignee: University of Akron
    Inventor: Shing-Chung Wong
  • Patent number: 9809630
    Abstract: The present invention is directed to enzyme based methods for separating protein from protein-rich materials derived from plant seeds, fruit, or other biomass and products made therefrom. The protein content in the resulting products is improved by separating and removing the carbohydrates from around the proteins in, for example, soybean meal. This removal is facilitated by the enzymatic hydrolysis of poly- and oligomeric carbohydrates into monosaccharides and other water soluble sugars. The present invention provides for the production of three streams of useful materials. The first is an enriched protein material comparable to the known SPCs but without significant quantities of undigestible oligosaccharides and polysaccharides. The second is an SPI made from the soluble protein in the hydrolysate which is valuable for high-quality feed, food and industrial uses.
    Type: Grant
    Filed: May 9, 2013
    Date of Patent: November 7, 2017
    Assignee: THE UNIVERSITY OF AKRON
    Inventors: Lu-Kwang Ju, Abdullah Loman, Anthony Coffman, Qian Li, Srujana Koganti