Patents Assigned to The University of Alabama in Birmingham
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Patent number: 5453533Abstract: An influenza virus neuraminidase inhibitor, its analogs, its pharmaceutically acceptable salts, derivatives, and mixtures thereof having the following formula: ##STR1## where A is CO.sub.2 H, CO.sub.2 H.sub.3, NO.sub.2, SO.sub.3 H or PO.sub.3 H.sub.2, B is CH, N, O or S, R.sub.1 and R.sub.2 are H, NO.sub.2 or (CH.sub.m).sub.n X.sub.1 where m=1 or 2, n is an integer from 0 to 4 and X.sub.1 is guanidino, OH, NH.sub.2, SH, NO.sub.2, F, Cl, Br, I, CN, CF.sub.3, CO.sub.2 H, SO.sub.3 H or PO.sub.3 H.sub.2, R.sub.3 and R.sub.4 are H, (CH.sub.o).sub.p X.sub.2, (CH.sub.o).sub.p CHX.sub.2 CH.sub.2 X.sub.2, NH(CH.sub.o).sub.p CHX.sub.2 CH.sub.2 X.sub.2, NHCO(CH.sub.o).sub.p CH.sub.2 X.sub.2 or NHCO(CH.sub.o).sub.p CHX.sub.2 CH.sub.2 X.sub.2 where o=1 or 2, p is an integer from 0 to 4 and X.sub.2 is H, guanidino, OH, NH.sub.2, SH, NO.sub.2, CF.sub.3, CO.sub.2 H, SO.sub.3 H or PO.sub.3 H.sub.2 , R.sub.5 =H, OH, NH.sub.2, (CH.sub.k).sub.1 X.sub.3, CO(CH.sub.k).sub.1 X.sub.3, SO(CH.sub.k).sub.1 X.sub.3 or SO.sub.2 (CH.sub.Type: GrantFiled: April 14, 1994Date of Patent: September 26, 1995Assignee: The University of Alabama at BirminghamInventors: Ming Luo, Wayne J. Brouillette, Gillian Air
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Patent number: 5159067Abstract: Compounds of the general formula: ##STR1## wherein A, B, and C are hydrogen, halogen, or azido; D is hydrogen, halogen, azido, or OH; A and B or C and D can be replaced with a double bond; R is an aldohexose, aldohexosamine, or N-acetyl aldohexosamine, R.sub.1 and R.sub.2 are hydrogen or alkyl groups of from C.sub.1 to C.sub.10 ; W is oxygen or sulfur; X is oxygen, sulfur, or CH.sub.2 ; Y is a purine or pyrimidine base, and Z is carbon, sulfur, or oxygen. Y can be any purine or pyrimidine base, natural or synthetic, which combines with a sugar to form a biologically active nucleoside. In combination with an appropriate pharmaceutical carrier, the compositions have enhanced activity or increased intracellular absorbment over the parent nucleoside as a function of the 5'-O-diphosphosugar.Type: GrantFiled: July 10, 1989Date of Patent: October 27, 1992Assignees: University of Georgia Research Foundation Inc., University of Alabama at Birmingham Research Foundation, Inc.Inventors: Raymond F. Schinazi, Jean-Pierre Sommadossi, Chum K. Chung
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Patent number: 5138167Abstract: An energy discriminating apparatus and method is disclosed for use in connection with digital radiography and fluoroscopy. In use of the detection system and method an x-ray source is actuated to direct x-rays through a patient's body, the x-rays including both higher and lower energy radiation. A first detector element, including a plurality of segments, is positioned opposite the source to receive and respond predominantly to x-rays in a lower energy range, the remaining x-rays, being generally of higher energy, passing through the first detector element. A second detector element, also including a plurality of segments, each segment including a phosphor coating layer and a sensor, is positioned to receive and respond to the higher energy radiation passing through the first element.Type: GrantFiled: January 23, 1991Date of Patent: August 11, 1992Assignee: University of Alabama - BirminghamInventor: Gary T. Barnes
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Patent number: 5081289Abstract: A method of separating nonpaline derivatives from their diastereoisomers is disclosed along with a method of selectively growing strains of the bacterium A. tumefaciens. Also disclosed are novel general methods of synthesizing the nopaline and isonopaline of this invention. These novel compounds are useful for the selective growth of the agriculturally useful A. tumefaciens bacterium.Type: GrantFiled: May 30, 1989Date of Patent: January 14, 1992Assignee: The University of Alabama in BirminghamInventors: Kenneth B. Taylor, Leo M. Hall
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Patent number: 5032271Abstract: A mechanochemical engine cpaable of desalinating sea water or brackish water by the conversion of mechanical work to chemical work, which comprises: a) a housing containing an elastomeric material capable of being stretched, to thereby allow salt-diminished water to move into the elastomeric material, while substantially repelling solvated salt ions from entry thereto, b) means for stretching and relaxing said elastomeric material in said housing, in connection with said elastomeric material; and c) means for uptake of said sea water or brackish water into said housing, means for draining concentrated salt water from said housing, and means for draining desalinated water from said housing.Type: GrantFiled: September 20, 1989Date of Patent: July 16, 1991Assignee: University of Alabama at Birmingham/Research FoundationInventor: Dan W. Urry
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Patent number: 4898926Abstract: A bioelastomer containing repeating units comprising elastomeric tetrapeptide or pentapeptide units or a mixture thereof, wherein said repeating units comprise amino acid residues selected from the group consisting of hydrophobic amino acid residues and glycine residues, wherein said repeating units exist in a .beta.-turn which comprises a polypentapeptide unit of the formula:--.alpha.P.rho..OMEGA.G--.sub.nwherein P is a peptide-forming residue of L-proline; G is a peptide-forming residue of glycine; .alpha. is a peptide-forming residue of L-valine or an ionizable peptide-forming residue selected from the group consisting of residues of L-Glu, L-Asp, L-His, L-Lys and L-Tyr; .rho. is a peptide-forming residue of glycine or a peptide-forming residue of D-Glu, D-Asp, D-His, D-Lys and D-Tyr; and .OMEGA.Type: GrantFiled: June 15, 1987Date of Patent: February 6, 1990Assignee: The University of Alabama at Birmingham/Research FoundationInventor: Dan W. Urry
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Patent number: 4870055Abstract: A method of increasing the modulus of elasticity of a biopolymer is disclosed, which comprises incorporating a hexameric unit of the formula--X--(APGVGV).sub.n --Y--whereinA is a peptide-forming residue of L-alanine;P is a peptide-forming residue of L-proline;G is a peptide-forming residue of glycine;V is a peptide-forming residue of L-valine;X is PGVGV, GVGV, VGV, GV, V, or a covalent bond;Y is APGVG, APGV, APG, AP, A, or a covalent bond; andn is an integer from 2 to 200, wherein said hexameric unit comprises at least 18 amino acid residues, into an elastomeric polypeptide chain.Type: GrantFiled: April 8, 1988Date of Patent: September 26, 1989Assignee: University of Alabama at BirminghamInventors: Dan W. Urry, U. Prasad Kari
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Patent number: 4693718Abstract: A method of stimulating chemotaxis toward a prosthetic device is disclosed, which method comprises incorporating a chemotactic peptide of the formulaB.sup.1 -X-(AGVPGFGVG).sub.n -Y-B.sup.2whereinA is a peptide-forming residue of L-alanine:P is a peptide-forming residue of L-proline;G is a peptide-forming residue of glycine;V is a peptide-forming residue of L-valine;F is a peptide-forming residue of L-phenylalanine;B.sup.1 is H or a biocompatible N-terminal group;B.sup.2 is OH, OB.sup.3 where B.sup.3 is a non-toxic metal ion, or a biocompatible C-terminal group:X is GVPGFGVG, VPGFGVG, PGFGVG, GFGVG, FGVG, GVG, VG, G or a covalent bond;Y is AGVPGFGV, AGVPGFG, AGVPGF, AGVPG, AGVP, AGV, AG, A or a covalent bond; andn is an integer from 1 to 100;into a surface of the prosthetic device. Prosthetic devices which have the property of enhancing invasion of elastic fiber synthesizing fibroblasts as a result of the chemotactic peptide are also disclosed.Type: GrantFiled: October 31, 1985Date of Patent: September 15, 1987Assignee: University of Alabama in BirminghamInventors: Dan W. Urry, Marianna M. Long
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Patent number: 4615976Abstract: Novel octopine derivatives are disclosed which are useful for the selective growth of the agriculturally useful A. tumefaciens bacterium along with a synthetic method for their preparation. Also disclosed is a method of separating octopine derivatives from their diastereoisomers along with a method of selectively growing strains of the bacterium A. tumefaciens.Type: GrantFiled: August 15, 1983Date of Patent: October 7, 1986Assignee: The University of Alabama in BirminghamInventors: Kenneth B. Taylor, Leo M. Hall
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Patent number: 4605413Abstract: A method of stimulating chemotaxis toward a prosthetic device is disclosed, which method comprises incorporating a chemotactic peptide of the formulaB.sup.1 -X-(APGVGV).sub.n -Y-B.sup.2whereinA is a peptide-forming residue of L-alanine;P is a peptide-forming residue of L-proline;G is a peptide-forming residue of glycine;V is a peptide-forming residue of L-valine;B.sup.1 is H or a biocompatible N-terminal group;B.sup.2 is OH, OB.sup.3 where B.sup.3 is a non-toxic metal ion, or a biocompatible C-terminal group;X is PGVGV, GVGV, VGV, GV, V, or a covalent bond;Y is APGVG, APGV, APG, AP, A, or a covalent bond; andn is an integer from 1 to 100;into a surface of the prosthetic device. Prosthetic devices which have the property of enhancing invasion of elastic fiber synthesizing fibroblasts as a result of the chemotactic peptide are also disclosed.Type: GrantFiled: September 19, 1983Date of Patent: August 12, 1986Assignee: The University of Alabama at BirminghamInventors: Dan W. Urry, Robert M. Senior
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Patent number: 4500700Abstract: An elastomeric material comprising an elastomeric polypeptide, where the polypeptide comprises pentapeptide repeating units formed of amino acid residues selected from the group consisting of hydrophobic amino acid and glycine residues where the third amino acid residue of at least one repeating unit of the polypeptide has the D configuration if the remaining hydrophobic amino acids have the L configuration or the L configuration if the remaining hydrophobic amino acid residues have the D configuration and where the repeating units exist in a conformation having a .beta.-turn. Also disclosed are elastomeric fabrics formed from the elastomeric material and composites containing it and the use of such fabrics in vascular prosthesis, as well as a method of forming such elastomeric materials.Type: GrantFiled: December 23, 1982Date of Patent: February 19, 1985Assignee: The Board of Trustees of the University of Alabama for the University of Alabama in BirminghamInventor: Dan W. Urry
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Patent number: 4474851Abstract: An elastomeric composite material formed from an artificial core fiber and an elastomeric polypeptide chemically bonded to the surface of the core fiber, where the polypeptide comprises tetrapeptide or pentapeptide repeating units or mixtures thereof, the repeating units comprise hydrophobic amino acid or glycine residues, and the amino acid residues of a given repeating unit exist in a conformation having a .beta.-turn. Also disclosed are elastomeric fabrics formed from the elastomeric composite and the use of such fabrics in vascular prosthesis, as well as a method of forming such elastomeric composite materials.Type: GrantFiled: October 2, 1981Date of Patent: October 2, 1984Assignee: The University of Alabama in BirminghamInventor: Dan W. Urry
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Patent number: 4315157Abstract: A multiple beam computed tomography (CT) scanner formed of plural interspaced groups of small, densely packed radiation detectors provided in a stationary ring around a body. The ring defines the cross-sectional slice of the body which is scanned by moving an X-ray source in a circle having a smaller radius and the same plane and center as that of the detector ring. A rotatably mounted collimator having a plurality of beam defining apertures is positioned between the X-ray source and patient. The collimator defines a plurality of fan-shaped X-ray beams that strike the detectors after passing through the patient and eliminates radiation from impinging on the patient that would pass through and strike the dead spaces between detector groups. The X-ray source and collimator rotate synchronously maintaining the registration between any given X-ray beam and detector group while the area of interest for the given detector group is scanned by the X-ray beam.Type: GrantFiled: May 1, 1980Date of Patent: February 9, 1982Assignee: The University of Alabama in BirminghamInventor: Gary T. Barnes
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Patent number: 4170798Abstract: Apparatus to receive fecal material directly into a container and maintain it isolated, particularly as to its odors, while automatically homogenizing and withdrawing samples as may be desired and disposing of the remainder. The apparatus, either in fixed or portable form, includes connections to a source of homogenization fluid, a source of cleansing water, and a drain. It also includes means to mix the fecal material vigorously with the homogenization fluid to achieve a substantially homogeneous mixture which can be disposed of with relative ease and which can be sampled into a vacutainer through a vacutainer needle attached liquid-tight to the chamber containing the mixture. For multiple sampling, an automatically operated vacutainer changer brings one vacutainer at a time into position to have a sample of the mixture injected into it. Following such sampling, the apparatus and needle are automatically washed.Type: GrantFiled: May 5, 1977Date of Patent: October 16, 1979Assignee: University of Alabama in BirminghamInventor: Carlos L. Krumdieck
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Patent number: 4132746Abstract: An insoluble cross-linked polypentapeptide is totally synthesized by preparing two modified linear polypentapeptides patterned on the polypentapeptide from the pentapeptide (Val.sub.1 -Pro.sub.2 -Gly.sub.3 -Val.sub.4 -Gly.sub.5) one of the repeating peptide sequences contained in tropoelastin, the precursor protein of the core of the elastic fiber of the vascular wall, and by cross-linking the modified polypentapeptides. One of the intermediate polypentapeptides is modified by replacing a portion of at least one of the amino acid residues with the residue of an amino acid having more than one amino function and the other is modified by replacing a portion of at least one of the amino acid residues with the residue of an amino acid having more than one carboxyl function, to provide free amino groups on the one intermediate and free carboxyl groups on the other for interreaction in the presence of a suitable cross-linking agent.Type: GrantFiled: July 9, 1976Date of Patent: January 2, 1979Assignee: University of Alabama, Birmingham Medical & Education FoundationInventors: Dan W. Urry, Kouji Okamoto
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Patent number: 4114605Abstract: A saucer-shaped, resilient cup, sealed to a flat cover with an aperture in it to fit over the orifice of Stenson's duct from the parotid gland, adheres to the inside of the cheek, held in place by negative pressure, to collect the secretion of the parotid gland. Nothing protrudes from the mouth during collection of the sample.Type: GrantFiled: November 2, 1976Date of Patent: September 19, 1978Assignee: University of Alabama in BirminghamInventors: Jerry R. McGhee, Milton E. Schaefer
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Patent number: 4035661Abstract: An electronic timer for selectively timing the occurrence of electrically controllable events. The relative time spacing of events to be timed is stored or programmed in a memory by proportional storage in memory locations. This having been accomplished, execution of the program is effected by means of a selectable rate pulse generator which interrogates the memory. At those locations where positive data is stored, there results an output which is employed to perform a switching function.Type: GrantFiled: April 15, 1976Date of Patent: July 12, 1977Assignee: University of Alabama in BirminghamInventor: Gerald L. Carlson
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Patent number: 3949068Abstract: Injectable emulsion containing a medicament, a thixotropic agent and membe-forming substance having ion-exchange properties. The membrane-forming substance being a polymerizable monomer which polymerizes by reaction with a polymerizing agent.Type: GrantFiled: August 18, 1970Date of Patent: April 6, 1976Assignee: University of Alabama in Birmingham Medical and Educational FoundationInventor: Herbert S. Polin