Patents Assigned to The University of Alberta
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Patent number: 11833228Abstract: Beta-hydroxybutyric acid-based radiopharmaceuticals, pharmaceutical compositions comprising same, methods for preparing same, and methods of using same for diagnostic imaging and non-imaging tracer studies are provided.Type: GrantFiled: August 13, 2020Date of Patent: December 5, 2023Assignee: The Governors Of The University Of AlbertaInventors: Stephanie Mattingly, Frank Wuest, Ralf Schirrmacher, Melinda Wuest, Eugene Fine
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Patent number: 10882892Abstract: CsChrimson light-activated ion channel polypeptides, their encoding polynucleotides, and variants thereof are provided. Methods of introducing and using CsChrimson light activated ion channels and variants thereof for to alter cell activity and function are also provided.Type: GrantFiled: August 4, 2015Date of Patent: January 5, 2021Assignees: Massachusetts Institute of Technology, The Governors of The University of AlbertaInventors: Nathan Klapoetke, Brian Yichiun Chow, Edward Boyden, Gane Ka-Shu Wong, Yongku Peter Cho
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Patent number: 10472398Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.Type: GrantFiled: November 12, 2012Date of Patent: November 12, 2019Assignees: Massachusetts Institute of Technology, The Governors of The University of AlbertaInventors: Nathan Klapoetke, Brian Yichiun Chow, Edward Boyden, Gane Ka-Shu Wong, Yongku Peter Cho
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Patent number: 10472399Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.Type: GrantFiled: November 23, 2016Date of Patent: November 12, 2019Assignees: Massachusetts Institute of Technology, The Governors of The University of AlbertaInventors: Nathan Klapoetke, Brian Yichiun Chow, Edward Boyden, Gane Ka-Shu Wong, Yongku Peter Cho
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Publication number: 20190271701Abstract: Methods for the diagnosis of CRC, colorectal polyps in general and adenomatous polyps in particular by measurement of metabolites in urine are described. In some embodiments, certain metabolites are identified as being elevated or reduced in concentration or quantity in subjects with CRC and/or colorectal polyps as compared with subjects without CRC or colorectal polyps. The measurement of these metabolites in urine can indicate the presence of CRC or colorectal polyps in general or adanomatous polyps in particular in a subject.Type: ApplicationFiled: March 6, 2019Publication date: September 5, 2019Applicant: The Governors Of The University of AlbertaInventors: Richard Neil Fedorak, Haili Wang
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Patent number: 10175179Abstract: Apparatuses and methods for non-contact sensing of physical or chemical properties of a target sample using a planar microwave resonator are provided. In one aspect, a planar microwave resonator is used in combination with an active feedback loop for increasing the quality factor of the resonator to compensate for an existing signal loss in the sample or environment. In another aspect, an active feedback loop is used in combination with a microwave resonator to compensate for signal loss in a lossy medium. In another aspect, a planar microwave resonator comprising a secondary layer defining a sensing interface may be used to facilitate the sensing by exposing the secondary layer to a substance to be investigated. In another aspect, a planar microwave resonator sensor is provided comprising separate resonator and active feedback loop components that are indirectly connected through an electromagnetically coupling and may be constructed on two separate support structure.Type: GrantFiled: September 29, 2015Date of Patent: January 8, 2019Assignee: The Governors Of The University Of AlbertaInventors: Mojgan Daneshmand, Mohammad Hossein Zarifi
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Patent number: 9213945Abstract: A quantum device is provided that includes controllably quantum mechanically coupled dangling bonds extending from a surface of a semiconductor material. Each of the controllably quantum mechanically coupled dangling bonds has a separation of at least one atom of the semiconductor material. At least one electrode is provided for selectively modifying an electronic state of the controllably quantum mechanically coupled dangling bonds. By providing at least one additional electron within the controllably quantum mechanically coupled dangling bonds with the proviso that there exists at least one unoccupied dangling bond for each one additional electron present, the inventive device is operable at least to 293 degrees Kelvin and is largely immune to stray electrostatic perturbations. Room temperature operable quantum cellular automata and qubits are constructed thereform.Type: GrantFiled: July 31, 2014Date of Patent: December 15, 2015Assignees: National Research Council of Canada, The Governors of The University of AlbertaInventors: Gino A. Dilabio, Robert A. Wolkow, Jason L. Pitters, Paul G. Piva
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Patent number: 8974793Abstract: Described herein are methods and systems that can be used to induce immunologic tolerance to non-self antigens. The methods and systems comprise introducing a tolerogen comprising at least one immunogenic non-self antigen coupled to a carrier, wherein the immunogenic antigen can be a foreign or endogenous antigen or fragments thereof. The non-self antigen can be selected from the group consisting of carbohydrate antigens, full-length antigenic proteins, and fragments and combinations thereof, while the carrier can be selected from nanoparticles and stents. Tolerogen compositions are also provided and can be used to induce immunologic tolerance to non-self antigens. These methods, systems and compositions are particularly advantageous since they can be used to allow for the extension of the window of safety for immunologically-incompatible transplantations to patients who are growing past the age of infancy.Type: GrantFiled: December 11, 2009Date of Patent: March 10, 2015Assignee: The Governors Of The University Of AlbertaInventors: Lori Jeanne West, Todd Lambert Lowary, Jillian Mary Buriak, Brian Daly, Mylvaganam Jeyakanthan, Peter John Meloncelli, Vincent Arthur Wright, Anne Margaret Cooper
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Publication number: 20140289908Abstract: Transgenic plants with enhanced punicic acid accumulation result from over-expression of PgFADX and PgFAD2, and optionally, one or more of PgDGAT1, PgDGAT2, and PgPDAT1. The invention also relates to novel isolated Punica granatum diacylglycerol acyltransferases: type 1 (PgDGAT1), type 2 (PgDGAT2) and phospholipid:diacylglycerol acyltransferases (PgPDAT1); polynucleotide sequences encoding the DGATs and PDAT enzymes; polynucleotide constructs, vectors and host cells incorporating the polynucleotide sequences; and methods of producing and using same.Type: ApplicationFiled: March 25, 2014Publication date: September 25, 2014Applicant: The Governors of The University of AlbertaInventors: Randall J. WESELAKE, Elzbieta MIETKIEWSKA
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Patent number: 8816479Abstract: A quantum device is provided that includes controllably quantum mechanically coupled dangling bonds extending from a surface of a semiconductor material. Each of the controllably quantum mechanically coupled dangling bonds has a separation of at least one atom of the semiconductor material. At least one electrode is provided for selectively modifying an electronic state of the controllably quantum mechanically coupled dangling bonds. By providing at least one additional electron within the controllably quantum mechanically coupled dangling bonds with the proviso that there exists at least one unoccupied dangling bond for each one additional electron present, the inventive device is operable at least to 293 degrees Kelvin and is largely immune to stray electrostatic perturbations. Room temperature operable quantum cellular automata and qubits are constructed therefrom.Type: GrantFiled: June 17, 2009Date of Patent: August 26, 2014Assignees: National Research Council of Canada, The Governors of The University of AlbertaInventors: Gino A. Dilabio, Robert A. Wolkow, Jason L. Pitters, Paul G. Piva
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Patent number: 8633308Abstract: Described herein are compounds and methods that prevent the viral infection of cells. The compounds and methods described herein minimize viral resistance and maximize the number of targeted viruses. Additionally, the compounds and methods minimize the toxicity toward uninfected cells.Type: GrantFiled: February 27, 2008Date of Patent: January 21, 2014Assignee: The Governors of The University of AlbertaInventors: Luis M. Schang, Mireilli R. St. Vincent, Alexey V. Ustinov
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Patent number: 8293972Abstract: The invention is directed to recombinant antibodies which bind to Sclerotinia sclerotiorum antigens and comprise a single chain variable fragment (scFv). The antigen may be selected from SSPG1d or a portion thereof, aspartyl protease or a portion thereof, or whole Sclerotinia sclerotiorum mycelium. The invention also provides an antibody linked to an anti-fungal polypeptide. The invention extends to nucleic acid sequences encoding the antibodies, and expression vectors comprising the nucleic acid sequences. The invention is also directed to transgenic plants, seeds, tissues or cells transformed with the expression vectors. Methods for producing a transgenic plant that is resistant to Sclerotinia sclerotiorum, and for detecting Sclerotinia sclerotiorum in a biological sample utilizing an antibody which binds to Sclerotinia sclerotiorum antigen, and immunoassay kit for same are also provided.Type: GrantFiled: October 29, 2010Date of Patent: October 23, 2012Assignee: Governors of The University of AlbertaInventors: Nataraj Kav, William Yajima, Bo Yang
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Patent number: 8211295Abstract: Bitumen within raw oilsands may be cracked and fully recovered by light hydrocarbon extraction following exposure to modified natural zeolite catalysts under cracking conditions. The recovered bitumen is reduced in viscosity, with lower boiling point distributions. Effective cracking of oilsands bitumen using economical, abundant and readily disposable natural zeolites represents a significant step towards a waterless and environment friendly extraction process.Type: GrantFiled: April 27, 2009Date of Patent: July 3, 2012Assignees: The Governors Of The University Of Alberta, Imperial Oil Resource LimitedInventors: Steven M. Kuznicki, William C. McCaffrey, Murray R. Gray, James A. Dunn
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Patent number: 8039167Abstract: The present invention provides a fuel cell in which electricity is generated and a paraffin is converted to an olefin. Between the anode and cathode compartment of the fuel cell is a ceramic membrane of the formula BaCe0.85-eLfY0.05-0.25O(3-?) wherein L is a lanthanide and f is from 0 to 0.25 and ? is the oxygen deficiency in the ceramic.Type: GrantFiled: December 20, 2006Date of Patent: October 18, 2011Assignee: Governors of The University of AlbertaInventors: Jingli Luo, Karl Chuang, Alan Rodney Sanger
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Patent number: 7814402Abstract: An architecture and a method are provided for decoding codewords for codes such as low density parity check (LDPC) codes. An iterative decoding algorithm such as the Belief Propagation Algorithm (BPA) is employed that attempts to correct errors in an input block of symbols via a structure containing two sets of nodes through node processing and the passing of messages between nodes. Message passing and node processing is performed in a digit-serial manner instead of a bit-parallel manner.Type: GrantFiled: May 13, 2005Date of Patent: October 12, 2010Assignee: The Governors of The University of AlbertaInventors: Vincent Gaudet, Bruce Fordyce Cockburn, Christian Schlegel, Stephen Bates, Paul Andrew Goud, Robert Hang, Anthony Charles Rapley, Sheryl Howard
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Publication number: 20060211857Abstract: Steroid compounds having various oxygen substitution on the steroid nucleus are disclosed. A specific functionality present on many of the steroid compounds is oxygen substitution at both of positions 6 and 7. Thus, certain steroids have oxygen substitution at C6 and C7, and some have specific stereochemistries such as 6? and 7? oxygen substitution, and an alpha hydrogen at the 5 position in addition to having 6? and 7? oxygen substitution. Steroids having 3,4-epoxy functionality are also disclosed. In addition, steroids having C17 pyran and ?-lactone functionality, with oxygen substitution at C6 and C7, or at C15, of the steroid nucleus, are disclosed.Type: ApplicationFiled: November 22, 2005Publication date: September 21, 2006Applicants: Inflazyme Pharmaceuticals Ltd., The University of British Columbia, The University of AlbertaInventors: David Burgoyne, Yaping Shen, John Langlands, Christine Rogers, Joseph Chau, Edward Piers, Hassan Salari
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Patent number: 7090982Abstract: Methods of predicting therapeutic efficacy of treatment of a multiple sclerosis patients with peptides are provided. Multiple sclerosis patients can be screened for the presence of an human leukocyte antigen (HLA)-DR2 haplotype. The presence of the human leukocyte antigen (HLA)-DR2 haplotype in a patient is predictive of therapeutic efficacy of treatment.Type: GrantFiled: March 20, 2001Date of Patent: August 15, 2006Assignee: The Governors of The University of AlbertaInventors: Kenneth G. Warren, Ingrid Catz
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Patent number: 7067682Abstract: Steroid compounds having various oxygen substitution on the steroid nucleus are disclosed. A specific functionality present on many of the steroid compounds is oxygen substitution at both of positions 6 and 7. Thus, certain steroids have oxygen substitution at C6 and C7, and some have specific stereochemistries such as 6? and 7? oxygen substitution, and an alpha hydrogen at the 5 position in addition to having 6? and 7? oxygen substitution. Steroids having 3,4-epoxy functionality are also disclosed. In addition, steroids having C17 pyran and ?-lactone functionality, with oxygen substitution at C6 and C7, or at C15, of the steroid nucleus, are disclosed.Type: GrantFiled: November 6, 2003Date of Patent: June 27, 2006Assignees: Inflazyme Pharmaceuticals Ltd., The University of British Columbia, The University of AlbertaInventors: David L. Burgoyne, Yaping Shen, John M. Langlands, Christine Rogers, Joseph H L Chau, Edward Piers, Hassan Salari
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Publication number: 20050282896Abstract: The present invention provides compositions and methods for maintaining or improving cardiac function by administering a cardioprotective amount of dichloroacetate (DCA) and an inotropic drug. Also provided are dosage protocols and pharmaceutical compositions for use in these methods.Type: ApplicationFiled: December 15, 2004Publication date: December 22, 2005Applicant: The University of AlbertaInventors: Gary Lopaschuk, Ruth Collins-Nakai
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Patent number: 6959815Abstract: The present invention provides for a reactive oily bubble carrier comprising: (a) a gas bubble having an oil-coating; and (b) a collector dissolved within the oil-coating. The present invention also provides for the use a reactive oily bubble carrier in a flotation target particle separation process. The present invention also provides for a flotation target particle separation process using the reactive oily bubble carriers disclosed herein.Type: GrantFiled: January 22, 2003Date of Patent: November 1, 2005Assignee: The Governors of The University of AlbertaInventors: Zhenghe Xu, Jianjun Liu, Zhiang Zhou